Assessment of Structural Intolerance and Durability
General Structure Information 3lbx SPTB crystal structure of the erythrocyte spectrin tetramerization domain complex 2.8Å AUTH J.J.IPSARO,S.L.HARPER,T.E.MESSICK,R.MARMORSTEIN,A.MONDRAGON,AUTH 2 D.W.SPEICHERTITL CRYSTAL STRUCTURE AND FUNCTIONAL INTERPRETATION OF THETITL 2 ERYTHROCYTE SPECTRIN TETRAMERIZATION DOMAIN COMPLEX.REF BLOOD V. 115 4843 2010REFN ISSN 0006-4971PMID 20197550DOI 10.1182/BLOOD-2010-01-261396 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3fg7 VIL1 the crystal structure of villin domain 6 2.0Å AUTH H.WANG,S.CHUMNARNSILPA,A.LOONCHANTA,Q.LI,Y.M.KUAN,AUTH 2 S.ROBINE,M.LARSSON,I.MIHALEK,L.D.BURTNICK,AUTH 3 R.C.ROBINSONTITL HELIX-STRAIGHTENING AS AN ACTIVATION MECHANISM INTITL 2 THE GELSOLIN SUPERFAMILY OF ACTIN REGULATORYTITL 3 PROTEINSREF J.BIOL.CHEM. V. 284 21265 2009REFN ISSN 0021-9258PMID 19491107DOI 10.1074/JBC.M109.019760 Variant Set Distributions Mapped Variants
General Structure Information 1li1 COL4A2 the 1.9-a crystal structure of the noncollagenous (nc1) domain of human placenta collagen iv shows stabilization via a novel type of covalent met-lys cross-link 1.9Å AUTH M.E.THAN,S.HENRICH,R.HUBER,A.RIES,K.MANN,K.KUHN,AUTH 2 R.TIMPL,G.P.BOURENKOV,H.D.BARTUNIK,W.BODETITL THE 1.9-A CRYSTAL STRUCTURE OF THE NONCOLLAGENOUSTITL 2 (NC1) DOMAIN OF HUMAN PLACENTA COLLAGEN IV SHOWSTITL 3 STABILIZATION VIA A NOVEL […]
General Structure Information 2ha1 FN1 complex of the first and second type iii domains of human fibronectin in solution -1.0Å AUTH I.VAKONAKIS,D.STAUNTON,L.M.ROONEY,I.D.CAMPBELLTITL INTERDOMAIN ASSOCIATION IN FIBRONECTIN: INSIGHTTITL 2 INTO CRYPTIC SITES AND FIBRILLOGENESIS.REF EMBO J. V. 26 2575 2007REFN ISSN 0261-4189PMID 17464288DOI 10.1038/SJ.EMBOJ.7601694 Variant Set Distributions Mapped Variants
General Structure Information 4aej COL3A1 crystal structure of human fibrillar procollagen type iii c- propeptide trimer 2.21Å AUTH J.M.BOURHIS,N.MARIANO,Y.ZHAO,K.HARLOS,J.EXPOSITO,E.Y.JONES,AUTH 2 C.MOALI,N.AGHAJARI,D.J.S.HULMESTITL STRUCTURAL BASIS OF FIBRILLAR COLLAGEN TRIMERIZATION ANDTITL 2 RELATED GENETIC DISORDERS.REF NAT.STRUCT.MOL.BIOL. V. 19 1031 2012REFN ISSN 1545-9993PMID 23001006DOI 10.1038/NSMB.2389 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1u5m COL2A1 structure of a chordin-like cysteine-rich repeat (vwc module) from collagen iia -1.0Å AUTH J.M.OLEARY,J.M.HAMILTON,C.M.DEANE,N.V.VALEYEV,AUTH 2 L.J.SANDELL,A.K.DOWNINGTITL SOLUTION STRUCTURE AND DYNAMICS OF A PROTOTYPICALTITL 2 CHORDIN-LIKE CYSTEINE-RICH REPEAT (VON WILLEBRANDTITL 3 FACTOR TYPE C MODULE) FROM COLLAGEN IIAREF J.BIOL.CHEM. V. 279 53857 2004REFN ISSN 0021-9258PMID 15466413DOI 10.1074/JBC.M409225200 Variant Set Distributions Mapped […]
General Structure Information 1li1 COL4A1 the 1.9-a crystal structure of the noncollagenous (nc1) domain of human placenta collagen iv shows stabilization via a novel type of covalent met-lys cross-link 1.9Å AUTH M.E.THAN,S.HENRICH,R.HUBER,A.RIES,K.MANN,K.KUHN,AUTH 2 R.TIMPL,G.P.BOURENKOV,H.D.BARTUNIK,W.BODETITL THE 1.9-A CRYSTAL STRUCTURE OF THE NONCOLLAGENOUSTITL 2 (NC1) DOMAIN OF HUMAN PLACENTA COLLAGEN IV SHOWSTITL 3 STABILIZATION VIA A NOVEL […]
General Structure Information 2kl7 EFEMP2 solution nmr structure of the egf-like 1 domain of human fibulin-4. northeast structural genomics target hr6275 -1.0Å AUTH P.ROSSI,Y.CHIANG,S.ANDERSON,G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF THE EGF-LIKE 1 DOMAIN OFTITL 2 HUMAN FIBULIN-4. NORTHEAST STRUCTURAL GENOMICSTITL 3 TARGET HR6275REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2di9 FLNB solution structure of the 9th filamin domain from human filamin-b -1.0Å AUTH T.TOMIZAWA,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 9TH FILAMIN DOMAIN FROMTITL 2 HUMAN FILAMIN-BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1ujs ABLIM3 solution structure of the villin headpiece domain of human actin-binding lim protein homologue (kiaa0843 protein) -1.0Å AUTH N.TOCHIO,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE VILLIN HEADPIECE DOMAINTITL 2 OF HUMAN ACTIN-BINDING LIM PROTEIN HOMOLOGUETITL 3 (KIAA0843 PROTEIN)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants