Assessment of Structural Intolerance and Durability
General Structure Information 4B7L FLNB crystal structure of human filamin b actin binding domain with 1st filamin repeat 2.05Å AUTH G.M.SAWYER,A.J.SUTHERLAND-SMITHTITL CRYSTAL STRUCTURE OF THE FILAMIN N-TERMINAL REGION REVEALSTITL 2 A HINGE BETWEEN THE ACTIN BINDING AND FIRST REPEAT DOMAINSREF J.MOL.BIOL. V. 424 240 2012REFN ISSN 0022-2836PMID 23036857DOI 10.1016/J.JMB.2012.09.016 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1z5w TUBG1 crystal structure of gamma-tubulin bound to gtp 3.0Å AUTH H.ALDAZ,L.M.RICE,T.STEARNS,D.A.AGARDTITL INSIGHTS INTO MICROTUBULE NUCLEATION FROM THETITL 2 CRYSTAL STRUCTURE OF HUMAN GAMMA-TUBULIN.REF NATURE V. 435 523 2005REFN ISSN 0028-0836PMID 15917813DOI 10.1038/NATURE03586 Variant Set Distributions Mapped Variants
General Structure Information 3cnk FLNA crystal structure of the dimerization domain of human filamin a 1.65Å AUTH M.-D.SEO,S.-H.SEOK,H.IM,A.-R.KWON,S.-J.LEE,AUTH 2 H.-R.KIM,Y.CHO,D.PARK,B.-J.LEETITL CRYSTAL STRUCTURE OF THE DIMERIZATION DOMAIN OFTITL 2 HUMAN FILAMIN AREF PROTEINS V. 75 258 2008REFN ISSN 0887-3585PMID 19137608DOI 10.1002/PROT.22336 Variant Set Distributions Mapped Variants
General Structure Information 2m3t CRYGS solution-state nmr structure of wild-type human gamma(s)-crystallin -1.0Å AUTH C.N.KINGSLEY,W.D.BRUBAKER,S.MARKOVIC,A.DIEHL,A.J.BRINDLEY,AUTH 2 H.OSCHKINAT,R.W.MARTINTITL PREFERENTIAL AND SPECIFIC BINDING OF HUMAN ALPHATITL 2 B-CRYSTALLIN TO A CATARACT-RELATED VARIANT OF GAMMATITL 3 S-CRYSTALLIN.REF STRUCTURE V. 21 2221 2013REFN ISSN 0969-2126PMID 24183572DOI 10.1016/J.STR.2013.09.017 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2k3t FLNA solution structure of ig-like domain 23 from human filamin a -1.0Å AUTH F.NAKAMURA,O.HEIKKINEN,O.T.PENTIKAINEN,T.M.OSBORN,AUTH 2 K.E.KASZA,D.A.WEITZ,O.KUPIAINEN,P.PERMI,AUTH 3 I.KILPELAINEN,J.YLANNE,J.H.HARTWIG,T.P.STOSSELTITL MOLECULAR BASIS OF FILAMIN A-FILGAP INTERACTIONTITL 2 AND ITS IMPAIRMENT IN CONGENITAL DISORDERSTITL 3 ASSOCIATED WITH FILAMIN A MUTATIONSREF PLOS ONE V. 4 E4928 2009REFN ESSN 1932-6203PMID 19293932DOI 10.1371/JOURNAL.PONE.0004928 Variant Set Distributions Mapped […]
General Structure Information 2j3s FLNA crystal structure of the human filamin a ig domains 19 to 21 2.5Å AUTH Y.LAD,T.-R.KIEMA,P.JIANG,O.T.PENTIKANEN,C.H.COLES,AUTH 2 I.D.CAMPBELL,D.A.CALDERWOOD,J.YLANNETITL STRUCTURE OF THREE TANDEM FILAMIN DOMAINS REVEALSTITL 2 AUTO-INHIBITION OF LIGAND-BINDING.REF EMBO J. V. 26 3993 2007REFN ISSN 0261-4189PMID 17690686DOI 10.1038/SJ.EMBOJ.7601827 Variant Set Distributions Mapped Variants
General Structure Information 3qk3 CRYBB3 crystal structure of human beta-crystallin b3 1.95Å Variant Set Distributions Mapped Variants
General Structure Information 1ni2 EZR structure of the active ferm domain of ezrin 2.3Å AUTH W.J.SMITH,N.NASSAR,A.P.BRETSCHER,R.A.CERIONE,AUTH 2 P.A.KARPLUSTITL STRUCTURE OF THE ACTIVE N-TERMINAL DOMAIN OFTITL 2 EZRIN. CONFORMATIONAL AND MOBILITY CHANGESTITL 3 IDENTIFY KEYSTONE INTERACTIONS.REF J.BIOL.CHEM. V. 278 4949 2003REFN ISSN 0021-9258PMID 12429733DOI 10.1074/JBC.M210601200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 1lm7 DSP structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure 3.0Å AUTH H.J.CHOI,S.PARK-SNYDER,L.T.PASCOE,K.J.GREEN,AUTH 2 W.I.WEISTITL STRUCTURES OF TWO INTERMEDIATE FILAMENT-BINDINGTITL 2 FRAGMENTS OF DESMOPLAKIN REVEAL A UNIQUE REPEATTITL 3 MOTIF STRUCTURE.REF NAT.STRUCT.BIOL. V. 9 612 2002REFN ISSN 1072-8368PMID 12101406 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2d85 LCP1 solution structure of the fourth ch domain from human l- plastin -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FOURTH CH DOMAIN FROMTITL 2 HUMAN L-PLASTINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants