Assessment of Structural Intolerance and Durability
General Structure Information 3v6c USP2 crystal structure of usp2 in complex with mutated ubiquitin 1.7Å AUTH M.NECULAI,A.ERNST,S.SIDHU,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 C.BOUNTRA,J.WEIGELT,S.DHE-PAGANONTITL CRYSTAL STRUCTURE OF USP2 IN COMPLEX WITH MUTATED UBIQUITINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2f15 PRKAB2 glycogen-binding domain of the amp-activated protein kinase beta2 subunit 2.0Å AUTH J.R.WALKER,L.WYBENGA-GROOT,P.J.FINERTY JR.,AUTH 2 E.NEWMAN,F.M.MACKENZIE,J.WEIGELT,M.SUNDSTROM,AUTH 3 C.ARROWSMITH,A.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURE OF THE GLYCOGEN-BINDING DOMAIN OF THETITL 2 AMP-ACTIVATED PROTEIN KINASE BETA2 SUBUNITREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3b7x FKBP6 crystal structure of human fk506-binding protein 6 2.1Å AUTH J.R.WALKER,T.DAVIS,C.BUTLER-COLE,R.PARAMANATHAN,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL HUMAN FK506-BINDING PROTEIN 6.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2i3y GPX5 crystal structure of human glutathione peroxidase 5 2.0Å AUTH K.L.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE PEROXIDASE 5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2pxx ECE2 human putative methyltransferase mgc2408 1.3Å AUTH W.TEMPEL,H.WU,L.DOMBROVSKY,H.ZENG,P.LOPPNAU,H.ZHU,AUTH 2 A.N.PLOTNIKOV,A.BOCHKAREVTITL AN INTACT SAM-DEPENDENT METHYLTRANSFERASE FOLD ISTITL 2 ENCODED BY THE HUMAN ENDOTHELIN-CONVERTING ENZYME-2TITL 3 GENE.REF PROTEINS V. 74 789 2009REFN ISSN 0887-3585PMID 19089949DOI 10.1002/PROT.22299 Variant Set Distributions Mapped Variants
General Structure Information 3i2v MOCS3 crystal structure of human mocs3 rhodanese-like domain 1.25Å AUTH J.P.BACIK,J.R.WALKER,L.LOPEZ,Y.LI,J.WEIGELT,AUTH 2 C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL CRYSTAL STRUCTURE OF THE HUMAN MOCS3 RHODANESE-LIKETITL 2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2hrb CBR3 crystal structure of human carbonyl reductase 3, complexed with nadp+ 1.9Å AUTH E.S.PILKA,A.ROJKOVA,K.L.KAVANAGH,F.NIESEN,M.SUNDSTROM,AUTH 2 C.ARROWSMITH,J.WEIGELT,A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN CARBONYL REDUCTASE 3, COMPLEXEDTITL 2 WITH NADP+REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2f6q ECI2 the crystal structure of human peroxisomal delta3, delta2 enoyl coa isomerase (peci) 1.95Å AUTH A.TURNBULL,P.LUKACIK,N.SHAFQAT,C.SMEE,G.BERRIDGE,K.GUO,AUTH 2 F.VON DELFT,J.WEIGELT,M.SUNDSTROM,C.ARROWSMITH,A.EDWARDS,AUTH 3 O.GILEADI,U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN PEROXISOMAL DELTA3, DELTA2TITL 2 ENOYL COA ISOMERASE (PECI)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3mtg AHCYL1 crystal structure of human s-adenosyl homocysteine hydrolase-like 1 protein 2.64Å AUTH M.WISNIEWSKA,M.I.SIPONEN,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,M.MOCHE,P.NORDLUND,T.NYMAN,C.PERSSON,P.SCHUTZ,AUTH 5 A.G.THORSELL,L.TRESAUGUES,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,M.WELIN,H.SCHULERTITL CRYSTAL STRUCTURE OF HUMAN S-ADENOSYL HOMOCYSTEINETITL 2 HYDROLASE-LIKE 1 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2o2t MPDZ the crystal structure of the 1st pdz domain of mpdz 2.7Å AUTH E.PAPAGRIGORIOU,C.GILEADI,C.PHILLIPS,J.ELKINS,C.JOHANSSON,AUTH 2 E.SALAH,P.SAVITSKY,G.BERRIDGE,D.A.DOYLETITL THE CRYSTAL STRUCTURE OF THE 1ST PDZ DOMAIN OF MPDZREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants