Assessment of Structural Intolerance and Durability
General Structure Information 2rei EPHA7 kinase domain of human ephrin type-a receptor 7 (epha7) 1.6Å AUTH J.R.WALKER,D.CUERRIER,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 7TITL 2 (EPHA7).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kkt ATXN7L3 solution structure of the sca7 domain of human ataxin-7-l3 protein -1.0Å AUTH J.BONNET,Y.WANG,A.ATKINSON,J.KOFFLER,C.ROMIER,A.HAMICHE,AUTH 2 L.TORA,D.DEVYS,B.KIEFFERTITL HISTONE DEUBIQUITINATION BY SAGA IS MODULATED BY ANTITL 2 ATYPICAL ZINC FINGER DOMAIN OF ATAXIN-7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3i4u DHX8 crystal structure analysis of a helicase associated domain 2.1Å AUTH D.KUDLINZKI,A.SCHMITT,H.CHRISTIAN,R.FICNERTITL STRUCTURAL ANALYSIS OF THE C-TERMINAL DOMAIN OF THETITL 2 SPLICEOSOMAL HELICASE PRP22REF BIOL.CHEM. V. 393 1131 2012REFN ISSN 1431-6730PMID 23096351DOI 10.1515/HSZ-2012-0158 Variant Set Distributions Mapped Variants
General Structure Information 2m0g SF1 structure, phosphorylation and u2af65 binding of the nterminal domain of splicing factor 1 during 3 splice site recognition -1.0Å AUTH Y.ZHANG,T.MADL,I.BAGDIUL,T.KERN,H.S.KANG,P.ZOU,N.MAUSBACHER,AUTH 2 S.A.SIEBER,A.KRAMER,M.SATTLERTITL STRUCTURE, PHOSPHORYLATION AND U2AF65 BINDING OF THETITL 2 N-TERMINAL DOMAIN OF SPLICING FACTOR 1 DURING 3-SPLICE SITETITL 3 RECOGNITION.REF NUCLEIC ACIDS RES. V. 41 1343 2013REFN ISSN […]
General Structure Information 3f7p PLEC crystal structure of a complex between integrin beta4 and plectin 2.75Å AUTH J.M.DE PEREDA,M.P.LILLO,A.SONNENBERGTITL STRUCTURAL BASIS OF THE INTERACTION BETWEENTITL 2 INTEGRIN ALPHA6BETA4 AND PLECTIN AT THETITL 3 HEMIDESMOSOMESREF EMBO J. V. 28 1180 2009REFN ISSN 0261-4189PMID 19242489DOI 10.1038/EMBOJ.2009.48 Variant Set Distributions Mapped Variants
General Structure Information 2ke4 TRIP10 the nmr structure of the tc10 and cdc42 interacting domain of cip4 -1.0Å AUTH Y.KOBASHIGAWA,H.KUMETA,D.KANOH,F.INAGAKITITL THE NMR STRUCTURE OF THE TC10- ANDTITL 2 CDC42-INTERACTING DOMAIN OF CIP4.REF J.BIOMOL.NMR V. 44 113 2009REFN ISSN 0925-2738PMID 19387844DOI 10.1007/S10858-009-9317-Z Variant Set Distributions Mapped Variants
General Structure Information 4a8x RNPS1 structure of the core asap complex 1.9Å AUTH A.G.MURACHELLI,J.EBERT,C.BASQUIN,H.LE HIR,E.CONTITITL THE STRUCTURE OF THE ASAP CORE COMPLEX REVEALS THETITL 2 EXISTENCE OF A PININ-CONTAINING PSAP COMPLEXREF NAT.STRUCT.MOL.BIOL. V. 19 378 2012REFN ISSN 1545-9993PMID 22388736DOI 10.1038/NSMB.2242 Variant Set Distributions Mapped Variants
General Structure Information 3fzt PTK2B crystal structure of pyk2 complexed with pf-4618433 1.95Å AUTH S.HAN,A.MISTRY,J.S.CHANG,D.CUNNINGHAM,M.GRIFFOR,AUTH 2 P.C.BONNETTE,H.WANG,B.A.CHRUNYK,G.E.ASPNES,AUTH 3 D.P.WALKER,A.D.BROSIUS,L.BUCKBINDERTITL STRUCTURAL CHARACTERIZATION OF PROLINE-RICHTITL 2 TYROSINE KINASE 2 (PYK2) REVEALS A UNIQUE (DFG-OUT)TITL 3 CONFORMATION AND ENABLES INHIBITOR DESIGN.REF J.BIOL.CHEM. V. 284 13193 2009REFN ISSN 0021-9258PMID 19244237DOI 10.1074/JBC.M809038200 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2qag SEPT6 crystal structure of human septin trimer 2/6/7 4.0Å AUTH M.SIRAJUDDIN,M.FARKASOVSKY,F.HAUER,D.KUHLMANN,AUTH 2 I.G.MACARA,M.WEYAND,H.STARK,A.WITTINGHOFERTITL STRUCTURAL INSIGHT INTO FILAMENT FORMATION BYTITL 2 MAMMALIAN SEPTINS.REF NATURE V. 449 311 2007REFN ISSN 0028-0836PMID 17637674DOI 10.1038/NATURE06052 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ii6 XRCC4 structure of human xrcc4 in complex with the tandem brct domains of dna ligaseiv. 2.4Å AUTH P.Y.WU,P.FRIT,S.MEESALA,S.DAUVILLIER,M.MODESTI,AUTH 2 S.N.ANDRES,Y.HUANG,J.SEKIGUCHI,P.CALSOU,B.SALLES,AUTH 3 M.S.JUNOPTITL STRUCTURAL AND FUNCTIONAL INTERACTION BETWEEN THETITL 2 HUMAN DNA REPAIR PROTEINS DNA LIGASE IV AND XRCC4REF MOL.CELL.BIOL. V. 11 3163 2009REFN ISSN 0270-7306PMID 19332554 Variant Set Distributions Mapped Variants