Assessment of Structural Intolerance and Durability
General Structure Information 3to8 HNRNPL crystal structure of the two c-terminal rrm domains of heterogeneous nuclear ribonucleoprotein l (hnrnp l) 1.82Å AUTH W.J.ZHANG,F.X.ZENG,Y.W.LIU,Y.ZHAO,L.W.NIU,M.K.TENG,X.LITITL CRYSTAL STRUCTURE OF THE TWO C-TERMINAL RRM DOMAINS OFTITL 2 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L (HNRNP L)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3cw1 SNRNP70 crystal structure of human spliceosomal u1 snrnp 5.49Å AUTH D.A.POMERANZ KRUMMEL,C.OUBRIDGE,A.K.LEUNG,J.LI,K.NAGAITITL CRYSTAL STRUCTURE OF HUMAN SPLICEOSOMAL U1 SNRNP AT 5.5 ATITL 2 RESOLUTION.REF NATURE V. 458 475 2009REFN ISSN 0028-0836PMID 19325628DOI 10.1038/NATURE07851 Variant Set Distributions Mapped Variants
General Structure Information 2wfh SLIT2 the human slit 2 dimerization domain d4 1.8Å AUTH E.SEIRADAKE,A.C.VON PHILIPSBORN,M.HENRY,M.FRITZ,AUTH 2 H.LORTAT-JACOB,M.JAMIN,W.HEMRIKA,M.BASTMEYER,S.CUSACK,AUTH 3 A.A.MCCARTHYTITL STRUCTURE AND FUNCTIONAL RELEVANCE OF THE SLIT2TITL 2 HOMODIMERIZATION DOMAIN.REF EMBO REP. V. 10 736 2009REFN ISSN 1469-221XPMID 19498462DOI 10.1038/EMBOR.2009.95 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3s6n GEMIN2 crystal structure of the gemin2-binding domain of smn, gemin2 in complex with smd1/d2/f/e/g from human 2.5Å AUTH R.ZHANG,B.R.SO,P.LI,J.YONG,T.GLISOVIC,L.WAN,G.DREYFUSSTITL STRUCTURE OF A KEY INTERMEDIATE OF THE SMN COMPLEX REVEALSTITL 2 GEMIN2S CRUCIAL FUNCTION IN SNRNP ASSEMBLY.REF CELL(CAMBRIDGE,MASS.) V. 146 384 2011REFN ISSN 0092-8674PMID 21816274DOI 10.1016/J.CELL.2011.06.043 Variant Set Distributions Mapped Variants
General Structure Information 2hyi CASC3 structure of the human exon junction complex with a trapped dead-box helicase bound to rna 2.3Å AUTH C.B.F.ANDERSEN,L.BALLUT,J.S.JOHANSEN,H.CHAMIEH,AUTH 2 K.H.NIELSEN,C.L.OLIVEIRA,J.S.PEDERSEN,B.SERAPHIN,AUTH 3 H.LE HIR,G.R.ANDERSENTITL STRUCTURE OF THE EXON JUNCTION CORE COMPLEX WITH ATITL 2 TRAPPED DEAD-BOX ATPASE BOUND TO RNA.REF SCIENCE V. 313 1968 2006REFN ISSN 0036-8075PMID 16931718DOI 10.1126/SCIENCE.1131981 Variant Set […]