General Structure Information
| PDB ID | 2wfh |
| HGNC Gene Label(s) | SLIT2 |
| Structure Name | the human slit 2 dimerization domain d4 |
| Resolution | 1.8Å |
| Reference | AUTH E.SEIRADAKE,A.C.VON PHILIPSBORN,M.HENRY,M.FRITZ,AUTH 2 H.LORTAT-JACOB,M.JAMIN,W.HEMRIKA,M.BASTMEYER,S.CUSACK,AUTH 3 A.A.MCCARTHYTITL STRUCTURE AND FUNCTIONAL RELEVANCE OF THE SLIT2TITL 2 HOMODIMERIZATION DOMAIN.REF EMBO REP. V. 10 736 2009REFN ISSN 1469-221XPMID 19498462DOI 10.1038/EMBOR.2009.95 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 181 |
| Number Of SNVs | 46 |
| Number Of Permutations | 19706 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.059 |
| p-value | 0.068 |
COSMIC
| Number Of Residues | 181 |
| Number Of SNVs | 6 |
| Number Of Permutations | 425 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.2 |
| p-value | 0.792 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 46 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | -0.289 |
| p-value | 0.434 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
