Assessment of Structural Intolerance and Durability
General Structure Information 3maz STAP1 crystal structure of the human brdg1/stap-1 sh2 domain in complex with the ntal ptyr136 peptide 1.9Å AUTH T.KANEKO,H.HUANG,B.ZHAO,L.LI,H.LIU,C.K.VOSS,C.WU,AUTH 2 M.R.SCHILLER,S.S.LITITL LOOPS GOVERN SH2 DOMAIN SPECIFICITY BY CONTROLLING ACCESSTITL 2 TO BINDING POCKETS.REF SCI.SIGNAL. V. 3 RA34 2010REFN ESSN 1937-9145PMID 20442417DOI 10.1126/SCISIGNAL.2000796 Variant Set Distributions Mapped Variants
General Structure Information 2vhf CYLD structure of the cyld usp domain 2.8Å AUTH D.KOMANDER,C.J.LORD,H.SCHEEL,S.SWIFT,K.HOFMANN,AUTH 2 A.ASHWORTH,D.BARFORDTITL THE STRUCTURE OF THE CYLD USP DOMAIN EXPLAINS ITSTITL 2 SPECIFICITY FOR LYS63-LINKED POLYUBIQUITIN ANDTITL 3 REVEALS A B-BOX MODULEREF MOL.CELL.BIOL. V. 29 451 2008REFN ISSN 0270-7306PMID 18313383DOI 10.1016/J.MOLCEL.2007.12.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4fgu LGMN crystal structure of prolegumain 3.9Å AUTH E.DALL,H.BRANDSTETTERTITL MECHANISTIC AND STRUCTURAL STUDIES ON LEGUMAIN EXPLAIN ITSTITL 2 ZYMOGENICITY, DISTINCT ACTIVATION PATHWAYS, AND REGULATION.REF PROC.NATL.ACAD.SCI.USA V. 110 10940 2013REFN ISSN 0027-8424PMID 23776206DOI 10.1073/PNAS.1300686110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fjv OTUB2 crystal structure of human otubain2 and ubiquitin complex 2.05Å AUTH M.ALTUN,T.S.WALTER,H.B.KRAMER,P.HERR,A.IPHOFER,J.BOSTROM,AUTH 2 Y.DAVID,A.KOMSANY,N.TERNETTE,A.NAVON,D.I.STUART,J.REN,AUTH 3 B.M.KESSLERTITL THE HUMAN OTUBAIN2-UBIQUITIN STRUCTURE PROVIDES INSIGHTSTITL 2 INTO THE CLEAVAGE SPECIFICITY OF POLY-UBIQUITIN-LINKAGES.REF PLOS ONE V. 10 15344 2015REFN ESSN 1932-6203PMID 25590432DOI 10.1371/JOURNAL.PONE.0115344 Variant Set Distributions Mapped Variants
General Structure Information 3bd9 HS3ST5 human 3-o-sulfotransferase isoform 5 with bound pap 2.3Å AUTH D.XU,A.F.MOON,D.SONG,L.C.PEDERSEN,J.LIUTITL ENGINEERING SULFOTRANSFERASES TO MODIFY HEPARANTITL 2 SULFATE.REF NAT.CHEM.BIOL. V. 4 200 2008REFN ISSN 1552-4450PMID 18223645DOI 10.1038/NCHEMBIO.66 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3n9u CPSF7 crystal structure of the complex between the 25 kda subunit and the 59 kda subunit (rrm domain) of human cleavage factor im 1.92Å AUTH L.TRESAUGUES,M.WELIN,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 M.MOCHE,T.K.NIELSEN,T.NYMAN,C.PERSSON,H.SCHULER,P.SCHUTZ,AUTH 5 M.I.SIPONEN,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,M.WISNIEWSKA,P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE 25 KDA SUBUNITTITL 2 AND THE […]
General Structure Information 3l4c DOCK1 structural basis of membrane-targeting by dock180 2.37Å AUTH L.PREMKUMAR,A.A.BOBKOV,M.PATEL,L.JAROSZEWSKI,L.A.BANKSTON,AUTH 2 B.STEC,K.VUORI,J.F.COTE,R.C.LIDDINGTONTITL STRUCTURAL BASIS OF MEMBRANE TARGETING BY THE DOCK180TITL 2 FAMILY OF RHO FAMILY GUANINE EXCHANGE FACTORS (RHO-GEFS).REF J.BIOL.CHEM. V. 285 13211 2010REFN ISSN 0021-9258PMID 20167601DOI 10.1074/JBC.M110.102517 Variant Set Distributions Mapped Variants
General Structure Information 2hv7 PPP2R4 crystal structure of phosphotyrosyl phosphatase activator bound to atpgammas 2.5Å AUTH Y.CHAO,Y.XING,Y.CHEN,Y.XU,Z.LIN,Z.LI,P.D.JEFFREY,AUTH 2 J.B.STOCK,Y.SHITITL STRUCTURE AND MECHANISM OF THE PHOSPHOTYROSYLTITL 2 PHOSPHATASE ACTIVATOR.REF MOL.CELL V. 23 535 2006REFN ISSN 1097-2765PMID 16916641DOI 10.1016/J.MOLCEL.2006.07.027 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1z57 CLK1 crystal structure of human clk1 in complex with 10z-hymenialdisine 1.7Å AUTH A.N.BULLOCK,S.DAS,J.E.DEBRECZENI,P.RELLOS,O.FEDOROV,AUTH 2 F.H.NIESEN,K.GUO,E.PAPAGRIGORIOU,A.L.AMOS,S.CHO,B.E.TURK,AUTH 3 G.GHOSH,S.KNAPPTITL KINASE DOMAIN INSERTIONS DEFINE DISTINCT ROLES OF CLKTITL 2 KINASES IN SR PROTEIN PHOSPHORYLATION.REF STRUCTURE V. 17 352 2009REFN ISSN 0969-2126PMID 19278650DOI 10.1016/J.STR.2008.12.023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1xkt FASN human fatty acid synthase: structure and substrate selectivity of the thioesterase domain 2.6Å AUTH B.CHAKRAVARTY,Z.GU,S.S.CHIRALA,S.J.WAKIL,AUTH 2 F.A.QUIOCHOTITL HUMAN FATTY ACID SYNTHASE: STRUCTURE AND SUBSTRATETITL 2 SELECTIVITY OF THE THIOESTERASE DOMAIN.REF PROC.NATL.ACAD.SCI.USA V. 101 15567 2004REFN ISSN 0027-8424PMID 15507492DOI 10.1073/PNAS.0406901101 Variant Set Distributions Mapped Variants