Assessment of Structural Intolerance and Durability
General Structure Information 3t9l USP15 structure of n-terminal dusp-ubl domains of human usp15 1.5Å AUTH S.HARPER,T.M.BESONG,J.EMSLEY,D.J.SCOTT,I.DREVENYTITL STRUCTURE OF THE USP15 N-TERMINAL DOMAINS: A BETA-HAIRPINTITL 2 MEDIATES CLOSE ASSOCIATION BETWEEN THE DUSP AND UBL DOMAINSREF BIOCHEMISTRY V. 50 7995 2011REFN ISSN 0006-2960PMID 21848306DOI 10.1021/BI200726E Variant Set Distributions Mapped Variants
General Structure Information 2r3a SUV39H2 methyltransferase domain of human suppressor of variegation 3-9 homolog 2 2.0Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1lo6 KLK6 human kallikrein 6 (hk6) active form with benzamidine inhibitor at 1.56 a resolution 1.56Å AUTH M.J.BERNETT,S.I.BLABER,I.A.SCARISBRICK,AUTH 2 P.DHANARAJAN,S.M.THOMPSON,M.BLABERTITL CRYSTAL STRUCTURE AND BIOCHEMICAL CHARACTERIZATIONTITL 2 OF HUMAN KALLIKREIN 6 REVEALS A TRYPSIN-LIKETITL 3 KALLIKREIN IS EXPRESSED IN THE CENTRAL NERVOUSTITL 4 SYSTEMREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2ysm KMT2C solution structure of the first and second phd domain from myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST AND SECOND PHDTITL 2 DOMAIN FROM MYELOID/LYMPHOID OR MIXED-LINEAGETITL 3 LEUKEMIA PROTEIN 3 HOMOLOGREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3iq7 GSG2 crystal structure of human haspin in complex with 5-iodotubercidin 2.0Å AUTH J.ESWARAN,D.PATNAIK,P.FILIPPAKOPOULOS,F.WANG,R.L.STEIN,AUTH 2 J.W.MURRAY,J.M.HIGGINS,S.KNAPPTITL STRUCTURE AND FUNCTIONAL CHARACTERIZATION OF THE ATYPICALTITL 2 HUMAN KINASE HASPIN.REF PROC.NATL.ACAD.SCI.USA V. 106 20198 2009REFN ISSN 0027-8424PMID 19918057DOI 10.1073/PNAS.0901989106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2rfj BRDT crystal structure of the bromo domain 1 in human bromodomain containing protein, testis specific (brdt) 2.05Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2dll IRF4 solution structure of the irf domain of human interferon regulator factors 4 -1.0Å AUTH H.P.ZHANG,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE IRF DOMAIN OF HUMANTITL 2 INTERFERON REGULATOR FACTORS 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1rgo ZFP36L2 structural basis for recognition of the mrna class ii au- rich element by the tandem zinc finger domain of tis11d -1.0Å AUTH B.P.HUDSON,M.A.MARTINEZ-YAMOUT,H.J.DYSON,P.E.WRIGHTTITL RECOGNITION OF THE MRNA AU-RICH ELEMENT BY THETITL 2 ZINC FINGER DOMAIN OF TIS11D.REF NAT.STRUCT.MOL.BIOL. V. 11 257 2004REFN ISSN 1545-9993PMID 14981510DOI 10.1038/NSMB738 Variant Set Distributions Ripley’s […]