Assessment of Structural Intolerance and Durability
General Structure Information 2mkf UIMC1 solution structure of the e81 deletion mutant of the tandem uims of rap80 -1.0Å AUTH ANAMIKA,C.J.MARKIN,M.K.ROUT,L.SPYRACOPOULOSTITL MOLECULAR BASIS FOR IMPAIRED DNA DAMAGE RESPONSE FUNCTIONTITL 2 ASSOCIATED WITH THE RAP80 DELTA E81 DEFECT.REF J.BIOL.CHEM. V. 289 12852 2014REFN ISSN 0021-9258PMID 24627472DOI 10.1074/JBC.M113.538280 Variant Set Distributions Mapped Variants
General Structure Information 2×47 MACROD1 crystal structure of human macrod1 1.7Å AUTH D.CHEN,M.VOLLMAR,M.N.ROSSI,C.PHILLIPS,R.KRAEHENBUEHL,AUTH 2 D.SLADE,P.V.MEHROTRA,F.VON DELFT,S.K.CROSTHWAITE,O.GILEADI,AUTH 3 J.M.DENU,I.AHELTITL IDENTIFICATION OF MACRO DOMAIN PROTEINS AS NOVEL O-TITL 2 ACETYL-ADP-RIBOSE DEACETYLASES.REF J.BIOL.CHEM. V. 286 13261 2011REFN ISSN 0021-9258PMID 21257746DOI 10.1074/JBC.M110.206771 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2d9q CSF3R crystal structure of the human gcsf-receptor signaling complex 2.8Å AUTH T.TAMADA,E.HONJO,Y.MAEDA,T.OKAMOTO,M.ISHIBASHI,M.TOKUNAGA,AUTH 2 R.KUROKITITL HOMODIMERIC CROSS-OVER STRUCTURE OF THE HUMAN GRANULOCYTETITL 2 COLONY-STIMULATING FACTOR (GCSF) RECEPTOR SIGNALING COMPLEXREF PROC.NATL.ACAD.SCI.USA V. 103 3135 2006REFN ISSN 0027-8424PMID 16492764DOI 10.1073/PNAS.0511264103 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2r2q GABARAPL1 crystal structure of human gamma-aminobutyric acid receptor- associated protein-like 1 (gabarap1), isoform cra_a 1.65Å AUTH R.PARAMANATHAN,T.DAVIS,W.TEMPEL,S.MUJIB,AUTH 2 C.BUTLER-COLE,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,S.DHE-PAGANONTITL CRYSTAL STRUCTURE OF HUMAN GAMMA-AMINOBUTYRIC ACIDTITL 2 RECEPTOR-ASSOCIATED PROTEIN-LIKE 1 (GABARAP1),TITL 3 ISOFORM CRA_A.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4jxh CYTH2 complexe of arno sec7 domain with the protein-protein interaction inhibitor n-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide at ph 8.5 1.47Å AUTH J.ROUHANA,F.HOH,S.ESTARAN,C.HENRIQUET,Y.BOUBLIK,A.KERKOUR,AUTH 2 R.TROUILLARD,J.MARTINEZ,M.PUGNIERE,A.PADILLA,A.CHAVANIEUTITL FRAGMENT-BASED IDENTIFICATION OF A LOCUS IN THE SEC7 DOMAINTITL 2 OF ARNO FOR THE DESIGN OF PROTEIN-PROTEIN INTERACTIONTITL 3 INHIBITORSREF J.MED.CHEM. V. 56 8497 2013REFN ISSN 0022-2623PMID 24112024DOI 10.1021/JM4009357 Variant Set […]
General Structure Information 2rlo AGAP2 split ph domain of pi3-kinase enhancer -1.0Å AUTH J.YAN,W.WEN,L.N.CHAN,M.ZHANGTITL SPLIT PLECKSTRIN HOMOLOGY DOMAIN-MEDIATEDTITL 2 CYTOPLASMIC-NUCLEAR LOCALIZATION OF PI3-KINASETITL 3 ENHANCER GTPASEREF J.MOL.BIOL. V. 378 425 2008REFN ISSN 0022-2836PMID 18371979DOI 10.1016/J.JMB.2008.02.052 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ljk MIEN1 solution structure of the oncogenic-potential mien1 protein -1.0Å AUTH T.SHEN,C.CHANG,Y.CHANG,L.HUANG,C.HSUTITL SOLUTION STRUCTURE OF THE ONCOGENIC-POTENTIAL MIEN1 PROTEINTITL 2 REVEALS A THIOREDOXIN-LIKE FOLD WITH REDOX POTENTIALREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4ewi NLRP4 crystal structure of the nlrp4 pyrin domain 2.28Å AUTH C.EIBL,S.GRIGORIU,M.HESSENBERGER,J.WENGER,S.PUEHRINGER,AUTH 2 A.S.PINHEIRO,R.N.WAGNER,M.PROELL,J.C.REED,R.PAGE,AUTH 3 K.DIEDERICHS,W.PETITITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE NLRP4 PYRINTITL 2 DOMAIN.REF BIOCHEMISTRY V. 51 7330 2012REFN ISSN 0006-2960PMID 22928810DOI 10.1021/BI3007059 Variant Set Distributions Mapped Variants
General Structure Information 2y9q MKNK1 crystal structure of human erk2 complexed with a mapk docking peptide 1.55Å AUTH A.GARAI,A.ZEKE,G.GOGL,I.TORO,F.FORDOS,H.BLANKENBURG,AUTH 2 T.BARKAI,J.VARGA,A.ALEXA,D.EMIG,M.ALBRECHT,A.REMENYITITL SPECIFICITY OF LINEAR MOTIFS THAT BIND TO A COMMON MITOGEN-TITL 2 ACTIVATED PROTEIN KINASE DOCKING GROOVE.REF SCI. SIGNAL V. 5 74 2012REFN ESSN 1937-9145PMID 23047924DOI 10.1126/SCISIGNAL.2003004 Variant Set Distributions Mapped Variants
General Structure Information 4giw RUSC1 crystal structure of the run domain of human nesca 2.0Å AUTH Q.SUN,C.HAN,L.LIU,Y.WANG,H.DENG,L.BAI,T.JIANGTITL CRYSTAL STRUCTURE AND FUNCTIONAL IMPLICATION OF THE RUNTITL 2 DOMAIN OF HUMAN NESCAREF PROTEIN CELL V. 3 609 2012REFN ISSN 1674-800XPMID 22821014DOI 10.1007/S13238-012-2052-3 Variant Set Distributions Mapped Variants