Assessment of Structural Intolerance and Durability
General Structure Information 3mop MYD88 the ternary death domain complex of myd88, irak4, and irak2 3.4Å AUTH S.C.LIN,Y.C.LO,H.WUTITL HELICAL ASSEMBLY IN THE MYD88-IRAK4-IRAK2 COMPLEX INTITL 2 TLR/IL-1R SIGNALLING.REF NATURE V. 465 885 2010REFN ISSN 0028-0836PMID 20485341DOI 10.1038/NATURE09121 Variant Set Distributions Mapped Variants
General Structure Information 2p39 FGF23 crystal structure of human fgf23 1.5Å AUTH R.GOETZ,A.BEENKEN,O.A.IBRAHIMI,J.KALININA,AUTH 2 S.K.OLSEN,A.V.ELISEENKOVA,C.XU,T.A.NEUBERT,F.ZHANG,AUTH 3 R.J.LINHARDT,X.YU,K.E.WHITE,T.INAGAKI,S.A.KLIEWER,AUTH 4 M.YAMAMOTO,H.KUROSU,Y.OGAWA,M.KURO-O,B.LANSKE,AUTH 5 M.S.RAZZAQUE,M.MOHAMMADITITL MOLECULAR INSIGHTS INTO THE KLOTHO-DEPENDENT,TITL 2 ENDOCRINE MODE OF ACTION OF FIBROBLAST GROWTHTITL 3 FACTOR 19 SUBFAMILY MEMBERS.REF MOL.CELL.BIOL. V. 27 3417 2007REFN ISSN 0270-7306PMID 17339340DOI 10.1128/MCB.02249-06 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2lb2 NEDD4L structure of the second domain of human nedd4l in complex with a phosphorylated ptpy motif derived from human smad3 -1.0Å AUTH E.ARAGON,N.GOERNER,A.I.ZAROMYTIDOU,Q.XI,A.ESCOBEDO,AUTH 2 J.MASSAGUE,M.J.MACIASTITL A SMAD ACTION TURNOVER SWITCH OPERATED BY WW DOMAIN READERSTITL 2 OF A PHOSPHOSERINE CODE.REF GENES DEV. V. 25 1275 2011REFN ISSN 0890-9369PMID 21685363DOI 10.1101/GAD.2060811 Variant […]
General Structure Information 3zjb TRAF4 the structure of the traf domain of human traf4 1.84Å AUTH A.ROUSSEAU,A.G.MCEWEN,P.POUSSIN-COURMONTAGNE,D.ROGNAN,AUTH 2 Y.NOMINE,M.-C.RIO,C.TOMASETTO,F.ALPYTITL TRAF4 IS A NOVEL PHOSPHOINOSITIDE-BINDING PROTEINTITL 2 MODULATING TIGHT JUNCTIONS AND FAVORING CELL MIGRATION.REF PLOS BIOL. V. 11 1726 2013REFN ISSN 1544-9173PMID 24311986DOI 10.1371/JOURNAL.PBIO.1001726 Variant Set Distributions Mapped Variants
General Structure Information 2coa PRKD2 solution structure of the ph domain of protein kinase c, d2 type from human -1.0Å AUTH H.LI,K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF PROTEINTITL 2 KINASE C, D2 TYPE FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4n1d NODAL nodal/bmp2 chimera nb250 1.91Å AUTH L.ESQUIVIES,A.BLACKLER,M.PERAN,C.RODRIGUEZ-ESTEBAN,AUTH 2 J.C.IZPISUA BELMONTE,E.BOOKER,P.C.GRAY,C.AHN,W.KWIATKOWSKI,AUTH 3 S.CHOETITL DESIGNER NODAL/BMP2 CHIMERAS MIMIC NODAL SIGNALING, PROMOTETITL 2 CHONDROGENESIS, AND REVEAL A BMP2-LIKE STRUCTURE.REF J.BIOL.CHEM. V. 289 1788 2014REFN ISSN 0021-9258PMID 24311780DOI 10.1074/JBC.M113.529180 Variant Set Distributions Mapped Variants
General Structure Information 2ovj RACGAP1 the crystal structure of the human rac gtpase activating protein 1 (racgap1) mgcracgap. 1.49Å AUTH L.SHRESTHA,E.PAPAGRIGORIOU,M.SOUNDARARAJAN,J.ELKINS,AUTH 2 C.JOHANSSON,F.VON DELFT,A.C.W.PIKE,N.BURGESS,A.TURNBULL,AUTH 3 J.DEBRECZENI,F.GORREC,C.UMEANO,A.EDWARDS,C.H.ARROWSMITH,AUTH 4 J.WEIGELT,M.SUNDSTROM,D.A.DOYLETITL THE CRYSTAL STRUCTURE OF THE HUMAN RAC GTPASE ACTIVATINGTITL 2 PROTEIN 1 (RACGAP1) MGCRACGAP.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ew3 SH3GL3 solution structure of the sh3 domain of human sh3gl3 -1.0Å AUTH Y.G.GAO,X.Z.YAN,H.Y.HUTITL STRUCTURAL BASIS FOR THE BINDING SPECIFICITIES OFTITL 2 HUNTINGTIN PROLINE-RICH REGION WITH SH3 AND WWTITL 3 DOMAINSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4gl2 IFIH1 structural basis for dsrna duplex backbone recognition by mda5 3.56Å AUTH B.WU,A.PEISLEY,C.RICHARDS,H.YAO,X.ZENG,C.LIN,F.CHU,T.WALZ,AUTH 2 S.HURTITL STRUCTURAL BASIS FOR DSRNA RECOGNITION, FILAMENT FORMATION,TITL 2 AND ANTIVIRAL SIGNAL ACTIVATION BY MDA5.REF CELL(CAMBRIDGE,MASS.) V. 152 276 2013REFN ISSN 0092-8674PMID 23273991DOI 10.1016/J.CELL.2012.11.048 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2k8p SOST characterisation of the structural features and interactions of sclerostin: molecular insight into a key regulator of wnt-mediated bone formation -1.0Å AUTH V.VEVERKA,A.J.HENRY,P.M.SLOCOMBE,A.VENTOM,B.MULLOY,AUTH 2 F.W.MUSKETT,M.MUZYLAK,K.GREENSLADE,A.MOORE,L.ZHANG,AUTH 3 J.GONG,X.QIAN,C.PASZTY,R.J.TAYLOR,M.K.ROBINSON,AUTH 4 M.D.CARRTITL CHARACTERIZATION OF THE STRUCTURAL FEATURES ANDTITL 2 INTERACTIONS OF SCLEROSTIN: MOLECULAR INSIGHT INTOTITL 3 A KEY REGULATOR OF WNT-MEDIATED BONE FORMATIONREF J.BIOL.CHEM. […]