Assessment of Structural Intolerance and Durability
General Structure Information 2hxs RAB28 crystal structure of rab28a gtpase in the inactive (gdp-3p- bound) form 1.1Å AUTH S.H.LEE,Y.LI,R.DOMINGUEZTITL THE CRYSTAL STRUCTURE OF RAB28 GTPASE IN ACTIVETITL 2 AND INACTIVE FORMSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lqn CRKL solution structure of crkl -1.0Å AUTH W.JANKOWSKI,T.SALEH,M.T.PAI,G.SRIRAM,R.B.BIRGE,C.G.KALODIMOSTITL DOMAIN ORGANIZATION DIFFERENCES EXPLAIN BCR-ABLS PREFERENCETITL 2 FOR CRKL OVER CRKII.REF NAT.CHEM.BIOL. V. 8 590 2012REFN ISSN 1552-4450PMID 22581121DOI 10.1038/NCHEMBIO.954 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kr6 PSEN1 solution structure of presenilin-1 ctf subunit -1.0Å AUTH V.DOETSCHTITL SOLUTION STRUCTURE OF PRESENILIN-1 CTF SUBUNITREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1t77 LRBA crystal structure of the ph-beach domains of human lrba/bgl 2.4Å AUTH D.GEBAUER,J.LI,G.JOGL,Y.SHEN,D.G.MYSZKA,L.TONGTITL CRYSTAL STRUCTURE OF THE PH-BEACH DOMAINS OF HUMANTITL 2 LRBA/BGLREF BIOCHEMISTRY V. 43 14873 2004REFN ISSN 0006-2960PMID 15554694DOI 10.1021/BI049498Y Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2eyz CRK ct10-regulated kinase isoform ii -1.0Å AUTH Y.KOBASHIGAWA,M.SAKAI,M.NAITO,M.YOKOCHI,H.KUMETA,AUTH 2 Y.MAKINO,K.OGURA,S.TANAKA,F.INAGAKITITL STRUCTURAL BASIS FOR THE TRANSFORMING ACTIVITY OFTITL 2 HUMAN CANCER-RELATED SIGNALING ADAPTOR PROTEIN CRK.REF NAT.STRUCT.MOL.BIOL. V. 14 503 2007REFN ISSN 1545-9993PMID 17515907DOI 10.1038/NSMB1241 Variant Set Distributions Mapped Variants
General Structure Information 2ys1 DNM2 solution structure of the ph domain of dynamin-2 from human -1.0Å AUTH H.LI,M.SATO,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF DYNAMIN-2TITL 2 FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ds6 ARHGDIB crystal structure of a rac-rhogdi complex 2.35Å AUTH K.SCHEFFZEK,I.STEPHAN,O.N.JENSEN,D.ILLENBERGER,AUTH 2 P.GIERSCHIKTITL THE RAC-RHOGDI COMPLEX AND THE STRUCTURAL BASISTITL 2 FOR THE REGULATION OF RHO PROTEINS BY RHOGDI.REF NAT.STRUCT.BIOL. V. 7 122 2000REFN ISSN 1072-8368PMID 10655614DOI 10.1038/72392 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1cmz RGS19 solution structure of gaip (galpha interacting protein): a regulator of g protein signaling -1.0Å AUTH E.DE ALBA,L.DE VRIES,M.G.FARQUHAR,N.TJANDRATITL SOLUTION STRUCTURE OF HUMAN GAIP (GALPHATITL 2 INTERACTING PROTEIN): A REGULATOR OF G PROTEINTITL 3 SIGNALING.REF J.MOL.BIOL. V. 291 927 1999REFN ISSN 0022-2836PMID 10452897DOI 10.1006/JMBI.1999.2989 Variant Set Distributions Mapped Variants
General Structure Information 2ekx BMX solution structure of the human bmx sh2 domain -1.0Å AUTH T.KASAI,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HUMAN BMX SH2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2f5y RGS3 crystal structure of the pdz domain from human rgs-3 2.39Å AUTH E.UGOCHUKWU,G.BERRIDGE,C.JOHANSSON,C.SMEE,P.SAVITSKY,AUTH 2 N.BURGESS,S.COLEBROOK,X.YANG,J.ELKINS,D.DOYLE,A.TURNBULL,AUTH 3 E.PAPAGRIGORIOU,J.DEBRECZENI,G.BUNKOCZI,F.GORREC,AUTH 4 F.VON DELFT,C.ARROWSMITH,M.SUNDSTROM,J.WEIGELT,A.EDWARDSTITL CRYSTAL STRUCTURE OF THE PDZ DOMAIN FROM HUMAN RGS-3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants