Assessment of Structural Intolerance and Durability
General Structure Information 2lnx VAV2 solution structure of vav2 sh2 domain -1.0Å AUTH B.WU,F.WANG,J.ZHANG,Z.ZHANG,L.QIN,J.PENG,F.LI,J.LIU,G.LU,AUTH 2 Q.GONG,X.YAO,J.WU,Y.SHITITL IDENTIFICATION AND STRUCTURAL BASIS FOR A NOVEL INTERACTIONTITL 2 BETWEEN VAV2 AND ARAP3.REF J.STRUCT.BIOL. V. 180 84 2012REFN ISSN 1047-8477PMID 22750419DOI 10.1016/J.JSB.2012.06.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1egx VASP solution structure of the ena-vasp homology 1 (evh1) domain of human vasodilator-stimulated phosphoprotein (vasp) -1.0Å AUTH L.J.BALL,R.KUHNE,B.HOFFMANN,A.HAFNER,P.SCHMIEDER,AUTH 2 R.VOLKMER-ENGERT,M.HOF,M.WAHL,J.SCHNEIDER-MERGENER,U.WALTER,AUTH 3 H.OSCHKINAT,T.JARCHAUTITL DUAL EPITOPE RECOGNITION BY THE VASP EVH1 DOMAIN MODULATESTITL 2 POLYPROLINE LIGAND SPECIFICITY AND BINDING AFFINITY.REF EMBO J. V. 19 4903 2000REFN ISSN 0261-4189PMID 10990454DOI 10.1093/EMBOJ/19.18.4903 Variant Set Distributions […]
General Structure Information 3eto NOTCH1 2 angstrom xray structure of the notch1 negative regulatory region (nrr) 2.0Å AUTH W.R.GORDON,M.ROY,D.VARDAR-ULU,M.GARFINKEL,M.R.MANSOUR,AUTH 2 J.C.ASTER,S.C.BLACKLOWTITL STRUCTURE OF THE NOTCH1-NEGATIVE REGULATORY REGION:TITL 2 IMPLICATIONS FOR NORMAL ACTIVATION AND PATHOGENIC SIGNALINGTITL 3 IN T-ALL.REF BLOOD V. 113 4381 2009REFN ISSN 0006-4971PMID 19075186DOI 10.1182/BLOOD-2008-08-174748 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2fu5 RABIF structure of rab8 in complex with mss4 2.0Å AUTH A.ITZEN,O.PYLYPENKO,R.S.GOODY,K.ALEXANDROV,A.RAKTITL NUCLEOTIDE EXCHANGE VIA LOCAL PROTEINTITL 2 UNFOLDING-STRUCTURE OF RAB8 IN COMPLEX WITH MSS4REF EMBO J. V. 25 1445 2006REFN ISSN 0261-4189PMID 16541104DOI 10.1038/SJ.EMBOJ.7601044 Variant Set Distributions Mapped Variants
General Structure Information 1x0h IQGAP1 solution structure of the carboxyl-terminal rgc domain in human iqgap1 -1.0Å AUTH K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CARBOXYL-TERMINAL RGCTITL 2 DOMAIN IN HUMAN IQGAP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3s9d IFNAR2 binary complex between ifna2 and ifnar2 2.0Å AUTH C.THOMAS,I.MORAGA,D.LEVIN,P.O.KRUTZIK,Y.PODOPLELOVA,A.TREJO,AUTH 2 C.LEE,G.YARDEN,S.E.VLECK,J.S.GLENN,G.P.NOLAN,J.PIEHLER,AUTH 3 G.SCHREIBER,K.C.GARCIATITL STRUCTURAL LINKAGE BETWEEN LIGAND DISCRIMINATION ANDTITL 2 RECEPTOR ACTIVATION BY TYPE I INTERFERONS.REF CELL(CAMBRIDGE,MASS.) V. 146 621 2011REFN ISSN 0092-8674PMID 21854986DOI 10.1016/J.CELL.2011.06.048 Variant Set Distributions Mapped Variants
General Structure Information 1i49 ARFIP2 crystal structure analysis of arfaptin 2.8Å AUTH C.TARRICONE,B.XIAO,N.JUSTIN,P.A.WALKER,K.RITTINGER,AUTH 2 S.J.GAMBLIN,S.J.SMERDONTITL THE STRUCTURAL BASIS OF ARFAPTIN-MEDIATEDTITL 2 CROSS-TALK BETWEEN RAC AND ARF SIGNALLING PATHWAYS.REF NATURE V. 411 215 2001REFN ISSN 0028-0836PMID 11346801DOI 10.1038/35075620 Variant Set Distributions Mapped Variants
General Structure Information 4mbs CCR5 crystal structure of the ccr5 chemokine receptor 2.71Å AUTH Q.TAN,Y.ZHU,J.LI,Z.CHEN,G.W.HAN,I.KUFAREVA,T.LI,L.MA,AUTH 2 G.FENALTI,J.LI,W.ZHANG,X.XIE,H.YANG,H.JIANG,V.CHEREZOV,AUTH 3 H.LIU,R.C.STEVENS,Q.ZHAO,B.WUTITL STRUCTURE OF THE CCR5 CHEMOKINE RECEPTOR-HIV ENTRY INHIBITORTITL 2 MARAVIROC COMPLEX.REF SCIENCE V. 341 1387 2013REFN ISSN 0036-8075PMID 24030490DOI 10.1126/SCIENCE.1241475 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1usd VASP human vasp tetramerisation domain l352m 1.7Å AUTH K.KUHNEL,T.JARCHAU,E.WOLF,I.SCHLICHTING,U.WALTER,AUTH 2 A.WITTINGHOFER,S.V.STRELKOVTITL THE VASP TETRAMERIZATION DOMAIN IS A RIGHT-HANDEDTITL 2 COILED COIL BASED ON A 15-RESIDUE REPEATREF PROC.NATL.ACAD.SCI.USA V. 101 17027 2004REFN ISSN 0027-8424PMID 15569942DOI 10.1073/PNAS.0403069101 Variant Set Distributions Mapped Variants
General Structure Information 1cc0 ARHGDIA crystal structure of the rhoa.gdp-rhogdi complex 5.0Å AUTH K.LONGENECKER,P.READ,U.DEREWENDA,Z.DAUTER,X.LIU,AUTH 2 S.GARRARD,L.WALKER,A.V.SOMLYO,R.K.NAKAMOTO,AUTH 3 A.P.SOMLYO,Z.S.DEREWENDATITL HOW RHOGDI BINDS RHO.REF ACTA CRYSTALLOGR.,SECT.D V. 55 1503 1999REFN ISSN 0907-4449PMID 10489445DOI 10.1107/S090744499900801X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants