Assessment of Structural Intolerance and Durability
General Structure Information 2cud SLA solution structure of the sh3 domain of the human src-like adopter protein (slap) -1.0Å AUTH S.OHNISHI,T.KIGAWA,N.TOCHIO,M.SATO,N.NAMEKI,AUTH 2 S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF THE HUMANTITL 2 SRC-LIKE ADOPTER PROTEIN (SLAP)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ee2 CNTN1 solution structures of the fn3 domain of human contactin 1 -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE FN3 DOMAIN OF HUMANTITL 2 CONTACTIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1j8e LRP1 crystal structure of ligand-binding repeat cr7 from lrp 1.85Å AUTH M.SIMONOVIC,K.DOLMER,W.HUANG,D.K.STRICKLAND,K.VOLZ,AUTH 2 P.G.GETTINSTITL CALCIUM COORDINATION AND PH DEPENDENCE OF THETITL 2 CALCIUM AFFINITY OF LIGAND-BINDING REPEAT CR7 FROMTITL 3 THE LRP. COMPARISON WITH RELATED DOMAINS FROM THETITL 4 LRP AND THE LDL RECEPTOR.REF BIOCHEMISTRY V. 40 15127 2001REFN ISSN 0006-2960PMID […]
General Structure Information 4k2p TIAM1 the structure of a quintuple mutant of the tiam1 ph-cc-ex domain 1.98Å AUTH M.JOSHI,L.GAKHAR,E.J.FUENTESTITL HIGH-RESOLUTION STRUCTURE OF THE TIAM1 PHN-CC-EX DOMAIN.REF ACTA CRYSTALLOGR.,SECT.F V. 69 744 2013REFN ESSN 1744-3091PMID 23832200DOI 10.1107/S1744309113014206 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3hk0 GRB10 crystal structure of the ra and ph domains of grb10 2.6Å AUTH R.S.DEPETRIS,J.WU,S.R.HUBBARDTITL STRUCTURAL AND FUNCTIONAL STUDIES OF THE RAS-ASSOCIATING ANDTITL 2 PLECKSTRIN-HOMOLOGY DOMAINS OF GRB10 AND GRB14.REF NAT.STRUCT.MOL.BIOL. V. 16 833 2009REFN ISSN 1545-9993PMID 19648926DOI 10.1038/NSMB.1642 Variant Set Distributions Mapped Variants
General Structure Information 3vhx KIF23 the crystal structure of arf6-mklp1 (mitotic kinesin-like protein 1) complex 2.81Å AUTH H.MAKYIO,M.OHGI,T.TAKEI,S.TAKAHASHI,H.TAKATSU,Y.KATOH,AUTH 2 A.HANAI,T.UEDA,Y.KANAHO,Y.XIE,H.W.SHIN,H.KAMIKUBO,M.KATAOKA,AUTH 3 M.KAWASAKI,R.KATO,S.WAKATSUKI,K.NAKAYAMATITL STRUCTURAL BASIS FOR ARF6-MKLP1 COMPLEX FORMATION ON THETITL 2 FLEMMING BODY RESPONSIBLE FOR CYTOKINESISREF EMBO J. V. 31 2590 2012REFN ISSN 0261-4189PMID 22522702DOI 10.1038/EMBOJ.2012.89 Variant Set Distributions Mapped Variants
General Structure Information 1qsc TRAF2 crystal structure of the traf domain of traf2 in a complex with a peptide from the cd40 receptor 2.4Å AUTH S.M.MCWHIRTER,S.S.PULLEN,J.M.HOLTON,J.J.CRUTE,AUTH 2 M.R.KEHRY,T.ALBERTITL CRYSTALLOGRAPHIC ANALYSIS OF CD40 RECOGNITION ANDTITL 2 SIGNALING BY HUMAN TRAF2.REF PROC.NATL.ACAD.SCI.USA V. 96 8408 1999REFN ISSN 0027-8424PMID 10411888DOI 10.1073/PNAS.96.15.8408 Variant Set Distributions Mapped Variants
General Structure Information 2oo4 NOTCH2 structure of lnr-hd (negative regulatory region) from human notch 2 2.0Å AUTH W.R.GORDON,D.VARDAR-ULU,G.HISTEN,C.SANCHEZ-IRIZARRY,AUTH 2 J.C.ASTER,S.C.BLACKLOWTITL STRUCTURAL BASIS FOR AUTOINHIBITION OF NOTCHREF NAT.STRUCT.MOL.BIOL. V. 14 295 2007REFN ISSN 1545-9993PMID 17401372DOI 10.1038/NSMB1227 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ks9 GRM1 metabotropic glutamate receptor mglur1 complexed with ly341495 antagonist 1.9Å AUTH E.DOBROVETSKY,G.KHUTORESKAYA,A.SEITOVA,D.COSSAR,A.M.EDWARDS,AUTH 2 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,A.BOCHKAREVTITL METABOTROPIC GLUTAMATE RECEPTOR MGLUR1 COMPLEXED WITHTITL 2 LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4n6j STRN3 crystal structure of human striatin-3 coiled coil domain 2.0Å AUTH C.C.CHEN,Z.B.SHI,W.Q.ZHANG,M.CHEN,F.HE,Z.Z.ZHANG,Y.C.WANG,AUTH 2 M.FENG,W.J.WANG,Y.ZHAO,J.H.BROWN,S.JIAO,Z.C.ZHOUTITL STRIATINS CONTAIN A NONCANONICAL COILED COIL THAT BINDS PP2ATITL 2 A TO FORM A 2:2 HETEROTETRAMERIC CORE OFTITL 3 STRIATIN-INTERACTING PHOSPHATASE AND KINASE (STRIPAK)TITL 4 COMPLEXREF J.BIOL.CHEM. 2014REFN ESSN 1083-351XDOI 10.1074/JBC.M113.529297 Variant Set Distributions Mapped Variants