General Structure Information
| PDB ID | 2oo4 |
| HGNC Gene Label(s) | NOTCH2 |
| Structure Name | structure of lnr-hd (negative regulatory region) from human notch 2 |
| Resolution | 2.0Å |
| Reference | AUTH W.R.GORDON,D.VARDAR-ULU,G.HISTEN,C.SANCHEZ-IRIZARRY,AUTH 2 J.C.ASTER,S.C.BLACKLOWTITL STRUCTURAL BASIS FOR AUTOINHIBITION OF NOTCHREF NAT.STRUCT.MOL.BIOL. V. 14 295 2007REFN ISSN 1545-9993PMID 17401372DOI 10.1038/NSMB1227 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 226 |
| Number Of SNVs | 49 |
| Number Of Permutations | 25156 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.037 |
| p-value | 0.008 |
COSMIC
| Number Of Residues | 226 |
| Number Of SNVs | 3 |
| Number Of Permutations | 109 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.667 |
| p-value | 0.671 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
