Assessment of Structural Intolerance and Durability
General Structure Information 3lb6 IL13RA2 the structure of il-13 in complex with il-13ralpha2 3.05Å AUTH P.J.LUPARDUS,M.E.BIRNBAUM,K.C.GARCIATITL MOLECULAR BASIS FOR SHARED CYTOKINE RECOGNITION REVEALED INTITL 2 THE STRUCTURE OF AN UNUSUALLY HIGH AFFINITY COMPLEX BETWEENTITL 3 IL-13 AND IL-13RALPHA2.REF STRUCTURE V. 18 332 2010REFN ISSN 0969-2126PMID 20223216DOI 10.1016/J.STR.2010.01.003 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2oo1 BRD3 crystal structure of the bromo domain 2 of human bromodomain containing protein 3 (brd3) 1.7Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1ujy ARHGEF6 solution structure of sh3 domain in rac/cdc42 guanine nucleotide exchange factor(gef) 6 -1.0Å AUTH F.HE,Y.MUTO,H.UDA,S.KOSHIBA,M.SHIROUZU,T.TERADA,AUTH 2 T.KIGAWA,M.INOUE,T.YABUKI,M.AOKI,E.SEKI,T.MATSUDA,AUTH 3 H.HIROTA,M.YOSHIDA,N.KOBAYASHI,A.TANAKA,T.OSANAI,AUTH 4 Y.MATSUO,O.OHARA,T.NAGASE,R.KIKUNO,M.NAGAYAMA,AUTH 5 S.YOKOYAMATITL SOLUTION STRUCTURE OF SH3 DOMAIN IN RAC/CDC42TITL 2 GUANINE NUCLEOTIDE EXCHANGE FACTOR(GEF) 6REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4cnc TPBG crystal structure of human 5t4 (wnt-activated inhibitory factor 1, trophoblast glycoprotein) 1.77Å AUTH Y.ZHAO,T.MALINAUSKAS,K.HARLOS,E.Y.JONESTITL STRUCTURAL INSIGHTS INTO THE INHIBITION OF WNT SIGNALING BYTITL 2 CANCER ANTIGEN 5T4/WNT-ACTIVATED INHIBITORY FACTOR 1.REF STRUCTURE V. 22 612 2014REFN ISSN 0969-2126PMID 24582434DOI 10.1016/J.STR.2014.01.009 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3sm9 GRM3 crystal structure of metabotropic glutamate receptor 3 precursor in presence of ly341495 antagonist 2.26Å AUTH A.K.WERNIMONT,A.DONG,A.SEITOVA,L.CROMBET,G.KHUTORESKAYA,AUTH 2 A.M.EDWARDS,C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,D.COSSAR,AUTH 3 E.DOBROVETSKYTITL CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR 3TITL 2 PRECURSOR IN PRESENCE OF LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3iez IQGAP2 crystal structure of the rasgap c-terminal (rgc) domain of iqgap2 1.5Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,N.ZHONG,L.CROMBET,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RASGAP C-TERMINAL (RGC)TITL 2 DOMAIN OF IQGAP2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3teq STIM1 crystal structure of soar domain 1.9Å AUTH X.YANG,H.JIN,X.CAI,S.LI,Y.SHENTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO THE ACTIVATION OFTITL 2 STROMAL INTERACTION MOLECULE 1 (STIM1).REF PROC.NATL.ACAD.SCI.USA V. 109 5657 2012REFN ISSN 0027-8424PMID 22451904DOI 10.1073/PNAS.1118947109 Variant Set Distributions Mapped Variants
General Structure Information 2qms GRB7 crystal structure of a signaling molecule 2.1Å AUTH C.J.PORTER,J.M.MATTHEWS,J.P.MACKAY,S.E.PURSGLOVE,AUTH 2 J.W.SCHMIDBERGER,P.J.LEEDMAN,S.C.PERO,D.N.KRAG,AUTH 3 M.C.WILCE,J.A.WILCETITL GRB7 SH2 DOMAIN STRUCTURE AND INTERACTIONS WITH ATITL 2 CYCLIC PEPTIDE INHIBITOR OF CANCER CELL MIGRATIONTITL 3 AND PROLIFERATION.REF BMC STRUCT.BIOL. V. 7 58 2007REFN ESSN 1472-6807PMID 17894853DOI 10.1186/1472-6807-7-58 Variant Set Distributions Mapped Variants
General Structure Information 4epu ANGPT1 ang1 fibrinogen-related domain (fred) 2.1Å AUTH C.C.YEYKAL,L.SUNDARESAN,M.MRKSICH,E.J.ADAMSTITL BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF THE ANG1TITL 2 FIBRINOGEN-RELATED DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4ku8 PRKG1 structures of pkgi reveal a cgmp-selective activation mechanism 1.99Å AUTH G.Y.HUANG,J.J.KIM,A.S.REGER,R.LORENZ,E.W.MOON,C.ZHAO,AUTH 2 D.E.CASTEEL,D.BERTINETTI,B.VANSCHOUWEN,R.SELVARATNAM,AUTH 3 J.W.PFLUGRATH,B.SANKARAN,G.MELACINI,F.W.HERBERG,C.KIMTITL STRUCTURAL BASIS FOR CYCLIC-NUCLEOTIDE SELECTIVITY ANDTITL 2 CGMP-SELECTIVE ACTIVATION OF PKG I.REF STRUCTURE V. 22 116 2014REFN ISSN 0969-2126PMID 24239458DOI 10.1016/J.STR.2013.09.021 Variant Set Distributions Mapped Variants