Assessment of Structural Intolerance and Durability
General Structure Information 4doh IL20RB il20/il201/il20r2 ternary complex 2.8Å AUTH N.J.LOGSDON,A.DESHPANDE,B.D.HARRIS,K.R.RAJASHANKAR,AUTH 2 M.R.WALTERTITL STRUCTURAL BASIS FOR RECEPTOR SHARING AND ACTIVATION BYTITL 2 INTERLEUKIN-20 RECEPTOR-2 (IL-20R2) BINDING CYTOKINES.REF PROC.NATL.ACAD.SCI.USA V. 109 12704 2012REFN ISSN 0027-8424PMID 22802649DOI 10.1073/PNAS.1117551109 Variant Set Distributions Mapped Variants
General Structure Information 2lpn CDNF solution structure of n-terminal domain of human conserved dopamine neurotrophic factor (cdnf) -1.0Å AUTH C.LATGE,K.M.CABRAL,M.S.ALMEIDA,D.FOGUELTITL (1)H-, (13)C- AND (15)N-NMR ASSIGNMENT OF THE N-TERMINALTITL 2 DOMAIN OF HUMAN CEREBRAL DOPAMINE NEUROTROPHIC FACTORTITL 3 (CDNF).REF BIOMOL.NMR ASSIGN. V. 7 101 2013REFN ISSN 1874-2718PMID 22528768DOI 10.1007/S12104-012-9388-8 Variant Set Distributions Mapped Variants
General Structure Information 1u7v SMAD2 crystal structure of the phosphorylated smad2/smad4 heterotrimeric complex 2.7Å AUTH B.M.CHACKO,B.Y.QIN,A.TIWARI,G.SHI,S.LAM,AUTH 2 L.J.HAYWARD,M.DE CAESTECKER,K.LINTITL STRUCTURAL BASIS OF HETEROMERIC SMAD PROTEINTITL 2 ASSEMBLY IN TGF-BETA SIGNALINGREF MOL.CELL V. 15 813 2004REFN ISSN 1097-2765PMID 15350224DOI 10.1016/J.MOLCEL.2004.07.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3qxl RALGPS1 crystal structure of the cdc25 domain from ral-specific guanine- nucleotide exchange factor ralgps1a 2.24Å AUTH W.PENG,J.XU,X.GUAN,Y.SUN,X.C.ZHANG,X.LI,Z.RAOTITL STRUCTURAL STUDY OF THE CDC25 DOMAIN FROM RAL-SPECIFICTITL 2 GUANINE-NUCLEOTIDE EXCHANGE FACTOR RALGPS1A.REF PROTEIN CELL V. 2 308 2011REFN ISSN 1674-800XPMID 21494904DOI 10.1007/S13238-011-1036-Z Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2khn ITSN1 nmr solution structure of the eh 1 domain from human intersectin-1 protein. northeast structural genomics consortium target hr3646e. -1.0Å AUTH J.L.MILLS,A.GHOSH,E.GARCIA,Q.ZHANG,R.SHASTRY,AUTH 2 E.L.FOOTE,H.JANJUA,T.B.ACTON,R.XIAO,J.K.EVERETT,AUTH 3 G.T.MONTELIONE,T.SZYPERSKITITL NMR SOLUTION STRUCTURE OF THE EH 1 DOMAIN FROMTITL 2 HUMAN INTERSECTIN-1 PROTEIN. NORTHEAST STRUCTURALTITL 3 GENOMICS CONSORTIUM TARGET HR3646E.REF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 2ekh SH3PXD2A solution structures of the sh3 domain of human kiaa0418 -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE SH3 DOMAIN OF HUMANTITL 2 KIAA0418REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2enk SLC30A9 solution structure of a putativ dna-binding domain of the humansolute carrier family 30 (zinc transporter) protein -1.0Å AUTH A.K.GORONCY,N.TOCHIO,T.TOMIZAWA,S.KOSHIBA,AUTH 2 S.WATANABE,T.HARADA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF A PUTATIV DNA-BINDING DOMAINTITL 2 OF THE HUMANSOLUTE CARRIER FAMILY 30 (ZINCTITL 3 TRANSPORTER) PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ucr TIGIT crystal structure of the immunoreceptor tigit igv domain 2.63Å AUTH K.F.STENGEL,K.HARDEN-BOWLES,X.YU,L.ROUGE,J.YIN,AUTH 2 L.COMPS-AGRAR,C.WIESMANN,J.F.BAZAN,D.L.EATON,J.L.GROGANTITL STRUCTURE OF TIGIT IMMUNORECEPTOR BOUND TO POLIOVIRUSTITL 2 RECEPTOR REVEALS A CELL-CELL ADHESION AND SIGNALINGTITL 3 MECHANISM THAT REQUIRES CIS-TRANS RECEPTOR CLUSTERING.REF PROC.NATL.ACAD.SCI.USA V. 109 5399 2012REFN ISSN 0027-8424PMID 22421438DOI 10.1073/PNAS.1120606109 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4bst RSPO1 structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p6122 crystal form 4.3Å AUTH W.C.PENG,W.DE LAU,F.FORNERIS,J.C.M.GRANNEMAN,M.HUCH,AUTH 2 H.CLEVERS,P.GROSTITL STRUCTURE OF STEM CELL GROWTH FACTOR R-SPONDIN 1 IN COMPLEXTITL 2 WITH THE ECTODOMAIN OF ITS RECEPTOR LGR5.REF CELL REP. V. 3 1885 2013REFN ISSN 2211-1247PMID 23809763DOI 10.1016/J.CELREP.2013.06.009 Variant […]
General Structure Information 4kng RNF43 crystal structure of human lgr5-rspo1-rnf43 2.5Å AUTH P.H.CHEN,X.CHEN,Z.LIN,D.FANG,X.HETITL THE STRUCTURAL BASIS OF R-SPONDIN RECOGNITION BY LGR5 ANDTITL 2 RNF43.REF GENES DEV. V. 27 1345 2013REFN ISSN 0890-9369PMID 23756651DOI 10.1101/GAD.219915.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants