Assessment of Structural Intolerance and Durability
General Structure Information 1ujv MAGI2 solution structure of the second pdz domain of human membrane associated guanylate kinase inverted-2 (magi-2) -1.0Å AUTH N.NAMEKI,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND PDZ DOMAIN OFTITL 2 HUMAN MEMBRANE ASSOCIATED GUANYLATE KINASETITL 3 INVERTED-2 (MAGI-2)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3isu IQGAP3 crystal structure of the rgc domain of iqgap3 1.88Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,L.CROMBET,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RGC DOMAIN OF IQGAP3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4h8s APPL2 crystal structure of human appl2barph domain 3.5Å AUTH G.J.KING,J.STOCKLI,S.H.HU,B.WINNEN,W.G.DUPREZ,C.C.MEOLI,AUTH 2 J.R.JUNUTULA,R.J.JARROTT,D.E.JAMES,A.E.WHITTEN,J.L.MARTINTITL MEMBRANE CURVATURE PROTEIN EXHIBITS INTERDOMAIN FLEXIBILITYTITL 2 AND BINDS A SMALL GTPASE.REF J.BIOL.CHEM. V. 287 40996 2012REFN ISSN 0021-9258PMID 23055524DOI 10.1074/JBC.M112.349803 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2d93 RAPGEF6 solution structure of the cnmp_binding domain of human rap guanine nucleotide exchange factor 6 -1.0Å AUTH K.INOUE,Y.MUTO,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CNMP_BINDING DOMAIN OFTITL 2 HUMAN RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2cs4 RASSF8 solution structure of n-terminal domain of chromosome 12 open reading frame 2 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF N-TERMINAL DOMAIN OFTITL 2 CHROMOSOME 12 OPEN READING FRAME 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dk9 MICAL1 solution structure of calponin homology domain of human mical-1 -1.0Å AUTH H.SUN,H.DAI,J.ZHANG,X.JIN,S.XIONG,J.XU,J.WU,Y.SHITITL SOLUTION STRUCTURE OF CALPONIN HOMOLOGY DOMAIN OFTITL 2 HUMAN MICAL-1REF J.BIOMOL.NMR V. 36 295 2006REFN ISSN 0925-2738PMID 17043746DOI 10.1007/S10858-006-9062-5 Variant Set Distributions Mapped Variants
General Structure Information 2hup RAB43 crystal structure of human rab43 in complex with gdp 2.05Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB43 IN COMPLEX WITHTITL 2 GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3t6g SH2D3C structure of the complex between nsp3 (shep1) and p130cas 2.5Å AUTH P.D.MACE,Y.WALLEZ,M.K.DOBACZEWSKA,J.J.LEE,H.ROBINSON,AUTH 2 E.B.PASQUALE,S.J.RIEDLTITL NSP-CAS PROTEIN STRUCTURES REVEAL A PROMISCUOUS INTERACTIONTITL 2 MODULE IN CELL SIGNALING.REF NAT.STRUCT.MOL.BIOL. V. 18 1381 2011REFN ISSN 1545-9993PMID 22081014DOI 10.1038/NSMB.2152 Variant Set Distributions Mapped Variants
General Structure Information 2rgn ARHGEF25 crystal structure of p63rhogef complex with galpha-q and rhoa 3.5Å AUTH S.LUTZ,A.SHANKARANARAYANAN,C.COCO,M.RIDILLA,M.R.NANCE,AUTH 2 C.VETTEL,D.BALTUS,C.R.EVELYN,R.R.NEUBIG,T.WIELAND,J.J.TESMERTITL STRUCTURE OF GALPHAQ-P63RHOGEF-RHOA COMPLEX REVEALS ATITL 2 PATHWAY FOR THE ACTIVATION OF RHOA BY GPCRS.REF SCIENCE V. 318 1923 2007REFN ISSN 0036-8075PMID 18096806DOI 10.1126/SCIENCE.1147554 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2ew1 RAB30 crystal structure of rab30 in complex with a gtp analogue 2.0Å AUTH J.WANG,Y.SHEN,S.ISMAIL,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,A.BOCHKAREV,H.W.PARKTITL CRYSTAL STRUCTURE OF RAB30 IN COMPLEX WITH A GTPTITL 2 ANALOGUEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants