Assessment of Structural Intolerance and Durability
General Structure Information 2k2m EPS8L1 structural basis of pxxdy motif recognition in sh3 binding -1.0Å AUTH O.AITIO,M.HELLMAN,T.KESTI,I.KLEINO,O.SAMUILOVA,AUTH 2 K.PAAKKONEN,H.TOSSAVAINEN,K.SAKSELA,P.PERMITITL STRUCTURAL BASIS OF PXXDY MOTIF RECOGNITION IN SH3TITL 2 BINDING.REF J.MOL.BIOL. V. 382 167 2008REFN ISSN 0022-2836PMID 18644376DOI 10.1016/J.JMB.2008.07.008 Variant Set Distributions Mapped Variants
General Structure Information 2jp2 SPRED2 solution structure and resonance assignment of the n- terminal evh1 domain from the human spred2 protein (sprouty-related protein with evh1 domain isoform 2) -1.0Å AUTH J.ZIMMERMANN,T.JARCHAU,U.WALTER,H.OSCHKINAT,AUTH 2 L.J.BALLTITL 1H, 13C AND 15N RESONANCE ASSIGNMENT OF THE HUMANTITL 2 SPRED2 EVH1 DOMAINREF J.BIOMOL.NMR V. 29 435 2004REFN ISSN 0925-2738PMID 15213456DOI 10.1023/B:JNMR.0000032526.17586.8C […]
General Structure Information 3dgc IL22RA1 structure of il-22/il-22r1 2.5Å AUTH B.C.JONES,N.J.LOGSDON,M.R.WALTERTITL STRUCTURE OF IL-22 BOUND TO ITS HIGH-AFFINITY IL-22R1 CHAIN.REF STRUCTURE V. 16 1333 2008REFN ISSN 0969-2126PMID 18599299DOI 10.1016/J.STR.2008.06.005 Variant Set Distributions Mapped Variants
General Structure Information 1ueq MAGI2 solution structure of the first pdz domain of human atrophin-1 interacting protein 1 (kiaa0705 protein) -1.0Å AUTH C.ZHAO,T.KIGAWA,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST PDZ DOMAIN OFTITL 2 HUMAN ATROPHIN-1 INTERACTING PROTEIN 1 (KIAA0705TITL 3 PROTEIN)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3gni STRADA structure of strad and mo25 2.35Å AUTH E.ZEQIRAJ,B.M.FILIPPI,S.GOLDIE,I.NAVRATILOVA,J.BOUDEAU,AUTH 2 M.DEAK,D.R.ALESSI,D.M.VAN AALTENTITL ATP AND MO25ALPHA REGULATE THE CONFORMATIONAL STATE OF THETITL 2 STRADALPHA PSEUDOKINASE AND ACTIVATION OF THE LKB1 TUMOURTITL 3 SUPPRESSORREF PLOS BIOL. V. 7 E1000 2009REFN ISSN 1544-9173PMID 19513107DOI 10.1371/JOURNAL.PBIO.1000126 Variant Set Distributions Mapped Variants
General Structure Information 3ixe LIMS2 structural basis of competition between pinch1 and pinch2 for binding to the ankyrin repeat domain of integrin-linked kinase 1.9Å AUTH B.P.CHISWELL,A.L.STIEGLER,Z.RAZINIA,E.NALIBOTSKI,AUTH 2 T.J.BOGGON,D.A.CALDERWOODTITL STRUCTURAL BASIS OF COMPETITION BETWEEN PINCH1 ANDTITL 2 PINCH2 FOR BINDING TO THE ANKYRIN REPEAT DOMAIN OFTITL 3 INTEGRIN-LINKED KINASE.REF J.STRUCT.BIOL. V. 170 157 2010REFN ISSN 1047-8477PMID […]
General Structure Information 2kom PARD3 solution structure of humar par-3b pdz2 (residues 451-549) -1.0Å AUTH D.R.JENSEN,C.WOYTOVICH,M.LI,P.DUVNJAK,M.S.CASSIDY,AUTH 2 R.O.FREDERICK,L.F.BERGEMAN,F.C.PETERSON,B.F.VOLKMANTITL RAPID, ROBOTIC, SMALL-SCALE PROTEIN PRODUCTION FORTITL 2 NMR SCREENING AND STRUCTURE DETERMINATION.REF PROTEIN SCI. V. 19 570 2010REFN ISSN 0961-8368PMID 20073081DOI 10.1002/PRO.335 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1u5d SKAP1 crystal structure of the ph domain of skap55 1.7Å AUTH Y.TANG,K.D.SWANSON,B.G.NEEL,M.J.ECKTITL STRUCTURAL BASIS FOR THE DIMERIZATION ANDTITL 2 PHOSPHOINOSITIDE SPECIFICITY OF THE SRCTITL 3 KINASE-ASSOCIATED PHOSPHOPROTEINS SKAP55 ANDTITL 4 SKAP-HOMREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3syx SPRED1 crystal structure of the wh1 domain from human sprouty-related, evh1 domain-containing protein. northeast structural genomics consortium target hr5538b. 2.45Å AUTH S.VOROBIEV,M.SU,J.SEETHARAMAN,S.SAHDEV,R.XIAO,C.CICCOSANTI,AUTH 2 R.SHASTRY,J.K.EVERETT,R.NAIR,T.B.ACTON,B.ROST,AUTH 3 G.T.MONTELIONE,L.TONG,J.F.HUNTTITL CRYSTAL STRUCTURE OF THE WH1 DOMAIN FROM HUMANTITL 2 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1uew MAGI2 solution structure of the forth pdz domain of human atrophin-1 interacting protein 1 (kiaa0705 protein) -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FORTH PDZ DOMAIN OFTITL 2 HUMAN ATROPHIN-1 INTERACTING PROTEIN 1 (KIAA0705TITL 3 PROTEIN)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants