Assessment of Structural Intolerance and Durability
General Structure Information 2wft HHIP crystal structure of the human hip ectodomain 2.8Å AUTH B.BISHOP,A.R.ARICESCU,K.HARLOS,C.A.OCALLAGHAN,AUTH 2 E.Y.JONES,C.SIEBOLDTITL STRUCTURAL INSIGHTS INTO HEDGEHOG LIGANDTITL 2 SEQUESTRATION BY THE HUMAN HEDGEHOG-INTERACTINGTITL 3 PROTEIN HIPREF NAT.STRUCT.MOL.BIOL. V. 16 698 2009REFN ISSN 1545-9993PMID 19561611DOI 10.1038/NSMB.1607 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ozn RTN4R 1.5a crystal structure of the nogo receptor ligand binding domain reveals a convergent recognition scaffold mediating inhibition of myelination 1.52Å AUTH X.L.HE,J.F.BAZAN,G.MCDERMOTT,J.B.PARK,K.WANG,AUTH 2 M.TESSIER-LAVIGNE,Z.HE,K.C.GARCIATITL STRUCTURE OF THE NOGO RECEPTOR ECTODOMAIN. A RECOGNITIONTITL 2 MODULE IMPLICATED IN MYELIN INHIBITION.REF NEURON V. 38 177 2003REFN ISSN 0896-6273PMID 12718853DOI 10.1016/S0896-6273(03)00232-0 Variant Set Distributions […]
General Structure Information 3n1g BOC crystal structure of dhhn bound to bocfn3 1.9Å AUTH J.M.KAVRAN,M.D.WARD,O.O.OLADOSU,S.MULEPATI,D.J.LEAHYTITL ALL MAMMALIAN HEDGEHOG PROTEINS INTERACT WITH CDO AND BOCTITL 2 IN A CONSERVED MANNER.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20519495DOI 10.1074/JBC.M110.131680 Variant Set Distributions Mapped Variants
General Structure Information 4ifp NLRP1 x-ray crystal structure of human nlrp1 card domain 1.99Å AUTH T.JIN,J.CURRY,P.SMITH,J.JIANG,T.S.XIAOTITL STRUCTURE OF THE NLRP1 CASPASE RECRUITMENT DOMAIN SUGGESTSTITL 2 POTENTIAL MECHANISMS FOR ITS ASSOCIATION WITH PROCASPASE-1.REF PROTEINS V. 81 1266 2013REFN ISSN 0887-3585PMID 23508996DOI 10.1002/PROT.24287 Variant Set Distributions Mapped Variants
General Structure Information 1ncu TTN titin module m5, n-terminally extended, nmr -1.0Å AUTH M.PFUHL,S.IMPROTA,A.S.POLITOUS,A.PASTORETITL WHEN A MODULE IS ALSO A DOMAIN: THE ROLE OF THE NTITL 2 TERMINUS IN THE STABILITY AND THE DYNAMICS OFTITL 3 IMMUNOGLOBULIN DOMAINS FROM TITIN.REF J.MOL.BIOL. V. 265 242 1997REFN ISSN 0022-2836PMID 9020985DOI 10.1006/JMBI.1996.0725 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3b13 DOCK2 crystal structure of the dhr-2 domain of dock2 in complex with rac1 (t17n mutant) 3.01Å AUTH K.HANAWA-SUETSUGU,M.KUKIMOTO-NIINO,C.MISHIMA-TSUMAGARI,AUTH 2 R.AKASAKA,N.OHSAWA,S.SEKINE,T.ITO,N.TOCHIO,S.KOSHIBA,AUTH 3 T.KIGAWA,T.TERADA,M.SHIROUZU,A.NISHIKIMI,T.URUNO,T.KATAKAI,AUTH 4 T.KINASHI,D.KOHDA,Y.FUKUI,S.YOKOYAMATITL STRUCTURAL BASIS FOR MUTUAL RELIEF OF THE RAC GUANINETITL 2 NUCLEOTIDE EXCHANGE FACTOR DOCK2 AND ITS PARTNER ELMO1 FROMTITL 3 THEIR AUTOINHIBITED FORMS.REF PROC.NATL.ACAD.SCI.USA V. 109 3305 […]
General Structure Information 2i1n DLG3 crystal structure of the 1st pdz domain of human dlg3 1.85Å AUTH J.M.ELKINS,E.PAPAGRIGORIOU,G.BERRIDGE,X.YANG,C.PHILLIPS,AUTH 2 C.GILEADI,P.SAVITSKY,D.A.DOYLETITL STRUCTURE OF PICK1 AND OTHER PDZ DOMAINS OBTAINED WITH THETITL 2 HELP OF SELF-BINDING C-TERMINAL EXTENSIONS.REF PROTEIN SCI. V. 16 683 2007REFN ISSN 0961-8368PMID 17384233DOI 10.1110/PS.062657507 Variant Set Distributions Mapped Variants
General Structure Information 1shz ARHGEF1 crystal structure of the p115rhogef rgrgs domain in a complex with galpha(13):galpha(i1) chimera 2.85Å AUTH Z.CHEN,W.D.SINGER,P.C.STERNWEIS,S.R.SPRANGTITL STRUCTURE OF THE P115RHOGEF RGRGSTITL 2 DOMAIN-GALPHA13/I1 CHIMERA COMPLEX SUGGESTSTITL 3 CONVERGENT EVOLUTION OF A GTPASE ACTIVATOR.REF NAT.STRUCT.MOL.BIOL. V. 12 191 2005REFN ISSN 1545-9993PMID 15665872DOI 10.1038/NSMB888 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2a5j RAB2B crystal structure of human rab2b 1.5Å AUTH J.WANG,A.DONG,Y.SHEN,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,A.BOCHKAREV,H.W.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB2BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1×40 ARAP2 solution structure of the sam domain of human arap2 -1.0Å AUTH A.SASAGAWA,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SAM DOMAIN OF HUMAN ARAP2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants