Assessment of Structural Intolerance and Durability
General Structure Information 2wtk CAB39 structure of the heterotrimeric lkb1-stradalpha-mo25alpha complex 2.65Å AUTH E.ZEQIRAJ,B.M.FILIPPI,M.DEAK,D.R.ALESSI,D.M.F.VAN AALTENTITL STRUCTURE OF THE LKB1-STRAD-MO25 COMPLEX REVEALS ANTITL 2 ALLOSTERIC MECHANISM OF KINASE ACTIVATION.REF SCIENCE V. 326 1707 2009REFN ISSN 0036-8075PMID 19892943DOI 10.1126/SCIENCE.1178377 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2el8 STAP2 solution structure of the human stap2 sh2 domain -1.0Å AUTH T.KASAI,K.MIYAMOTO,N.TOCHIO,T.TOMIZAWA,S.KOSHIBA,AUTH 2 S.WATANABE,T.HARADA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HUMAN STAP2 SH2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3vro CBLC crystal structure of the tyrosine kinase binding domain of cbl-c in complex with phospho-src peptide 1.8Å AUTH K.TAKESHITA,T.TEZUKA,Y.ISOZAKI,E.YAMASHITA,M.SUZUKI,M.KIM,AUTH 2 Y.YAMANASHI,T.YAMAMOTO,A.NAKAGAWATITL STRUCTURAL FLEXIBILITY REGULATES PHOSPHOPEPTIDE-BINDINGTITL 2 ACTIVITY OF THE TYROSINE KINASE BINDING DOMAIN OF CBL-C.REF J.BIOCHEM. V. 152 487 2012REFN ISSN 0021-924XPMID 22888118DOI 10.1093/JB/MVS085 Variant Set Distributions Mapped Variants
General Structure Information 4i2x SIRPG crystal structure of signal regulatory protein gamma (sirp-gamma) in complex with fabox117 2.48Å AUTH J.E.NETTLESHIP,J.REN,D.J.SCOTT,N.RAHMAN,D.HATHERLEY,Y.ZHAO,AUTH 2 D.I.STUART,A.N.BARCLAY,R.J.OWENSTITL CRYSTAL STRUCTURE OF SIGNAL REGULATORY PROTEIN GAMMA (SIRPTITL 2 GAMMA) IN COMPLEX WITH AN ANTIBODY FAB FRAGMENT.REF BMC STRUCT.BIOL. V. 13 13 2013REFN ESSN 1472-6807PMID 23826770DOI 10.1186/1472-6807-13-13 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1fb8 DAPP1 structure of the pleckstrin homology domain from dapp1/phish 2.4Å AUTH K.M.FERGUSON,J.M.KAVRAN,V.G.SANKARAN,E.FOURNIER,S.J.ISAKOFF,AUTH 2 E.Y.SKOLNIK,M.A.LEMMONTITL STRUCTURAL BASIS FOR DISCRIMINATION OF 3-PHOSPHOINOSITIDESTITL 2 BY PLECKSTRIN HOMOLOGY DOMAINS.REF MOL.CELL V. 6 373 2000REFN ISSN 1097-2765PMID 10983984DOI 10.1016/S1097-2765(00)00037-X Variant Set Distributions Mapped Variants
General Structure Information 1upq PLEKHA4 crystal structure of the pleckstrin homology (ph) domain of pepp1 1.48Å AUTH C.C.MILBURN,D.KOMANDER,M.DEAK,D.R.ALESSI,AUTH 2 D.M.F.VAN AALTENTITL CRYSTAL STRUCTURE OF THE PLECKSTRIN HOMOLOGYTITL 2 DOMAIN OF PEPP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3q2e BRWD1 crystal structure of the second bromodomain of human bromodomain and wd repeat-containing protein 1 isoform a (wdr9) 1.74Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 4h87 SLC4A1AP crystal structure of a fha domain of kanadaptin (slc4a1ap) from homo sapiens at 1.55 a resolution 1.55Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG)TITL CRYSTAL STRUCTURE OF A FHA DOMAIN OF KANADAPTIN (SLC4A1AP)TITL 2 FROM HOMO SAPIENS AT 1.55 A RESOLUTIONREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lb2 NEDD4L structure of the second domain of human nedd4l in complex with a phosphorylated ptpy motif derived from human smad3 -1.0Å AUTH E.ARAGON,N.GOERNER,A.I.ZAROMYTIDOU,Q.XI,A.ESCOBEDO,AUTH 2 J.MASSAGUE,M.J.MACIASTITL A SMAD ACTION TURNOVER SWITCH OPERATED BY WW DOMAIN READERSTITL 2 OF A PHOSPHOSERINE CODE.REF GENES DEV. V. 25 1275 2011REFN ISSN 0890-9369PMID 21685363DOI 10.1101/GAD.2060811 Variant […]
General Structure Information 2×47 MACROD1 crystal structure of human macrod1 1.7Å AUTH D.CHEN,M.VOLLMAR,M.N.ROSSI,C.PHILLIPS,R.KRAEHENBUEHL,AUTH 2 D.SLADE,P.V.MEHROTRA,F.VON DELFT,S.K.CROSTHWAITE,O.GILEADI,AUTH 3 J.M.DENU,I.AHELTITL IDENTIFICATION OF MACRO DOMAIN PROTEINS AS NOVEL O-TITL 2 ACETYL-ADP-RIBOSE DEACETYLASES.REF J.BIOL.CHEM. V. 286 13261 2011REFN ISSN 0021-9258PMID 21257746DOI 10.1074/JBC.M110.206771 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants