Assessment of Structural Intolerance and Durability
General Structure Information 2k2m EPS8L1 structural basis of pxxdy motif recognition in sh3 binding -1.0Å AUTH O.AITIO,M.HELLMAN,T.KESTI,I.KLEINO,O.SAMUILOVA,AUTH 2 K.PAAKKONEN,H.TOSSAVAINEN,K.SAKSELA,P.PERMITITL STRUCTURAL BASIS OF PXXDY MOTIF RECOGNITION IN SH3TITL 2 BINDING.REF J.MOL.BIOL. V. 382 167 2008REFN ISSN 0022-2836PMID 18644376DOI 10.1016/J.JMB.2008.07.008 Variant Set Distributions Mapped Variants
General Structure Information 4esr AHI1 molecular and structural characterization of the sh3 domain of ahi-1 in regulation of cellular resistance of bcr-abl+ chronic myeloid leukemia cells to tyrosine kinase inhibitors 1.53Å AUTH X.LIU,M.CHEN,P.LOBO,J.AN,S.W.GRACE CHENG,A.MORADIAN,AUTH 2 G.B.MORIN,F.VAN PETEGEM,X.JIANGTITL MOLECULAR AND STRUCTURAL CHARACTERIZATION OF THE SH3 DOMAINTITL 2 OF AHI-1 IN REGULATION OF CELLULAR RESISTANCE OF BCR-ABL(+)TITL […]
General Structure Information 1wxt EPS8L3 solution structure of the sh3 domain of human hypothetical protein flj21522 -1.0Å AUTH M.YONEYAMA,K.SAITO,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF HUMANTITL 2 HYPOTHETICAL PROTEIN FLJ21522REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3qbv ITSN1 structure of designed orthogonal interaction between cdc42 and nucleotide exchange domains of intersectin 2.65Å AUTH G.T.KAPP,S.LIU,A.STEIN,D.T.WONG,A.REMENYI,B.J.YEH,AUTH 2 J.S.FRASER,J.TAUNTON,W.A.LIM,T.KORTEMMETITL CONTROL OF PROTEIN SIGNALING USING A COMPUTATIONALLYTITL 2 DESIGNED GTPASE/GEF ORTHOGONAL PAIR.REF PROC.NATL.ACAD.SCI.USA V. 109 5277 2012REFN ISSN 0027-8424PMID 22403064DOI 10.1073/PNAS.1114487109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2ega SH3PXD2A solution structure of the first sh3 domain from human kiaa0418 protein -1.0Å AUTH K.INOUE,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST SH3 DOMAIN FROMTITL 2 HUMAN KIAA0418 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3lra LIN7C structural basis for assembling a human tripartite complex dlg1-mpp7- mals3 2.95Å AUTH X.YANG,X.XIE,L.CHEN,H.ZHOU,Z.WANG,W.ZHAO,R.TIAN,R.ZHANG,AUTH 2 C.TIAN,J.LONG,Y.SHENTITL STRUCTURAL BASIS FOR TANDEM L27 DOMAIN-MEDIATEDTITL 2 POLYMERIZATIONREF FASEB J. V. 24 4806 2010REFN ISSN 0892-6638PMID 20702775DOI 10.1096/FJ.10-163857 Variant Set Distributions Mapped Variants
General Structure Information 1uhc DNMBP solution structure of rsgi ruh-002, a sh3 domain of kiaa1010 protein [homo sapiens] -1.0Å AUTH T.ABE,H.HIROTA,N.KOBAYASHI,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF RSGI RUH-002, A SH3 DOMAINTITL 2 OF KIAA1010 PROTEIN [HOMO SAPIENS]REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1i1j MIA structure of melanoma inhibitory activity protein: a member of a new family of secreted proteins 1.39Å AUTH J.C.LOUGHEED,J.M.HOLTON,T.ALBER,J.F.BAZAN,AUTH 2 T.M.HANDELTITL STRUCTURE OF MELANOMA INHIBITORY ACTIVITY PROTEIN,TITL 2 A MEMBER OF A RECENTLY IDENTIFIED FAMILY OFTITL 3 SECRETED PROTEINS.REF PROC.NATL.ACAD.SCI.USA V. 98 5515 2001REFN ISSN 0027-8424PMID 11331761DOI 10.1073/PNAS.091601698 Variant Set Distributions […]
General Structure Information 1ug1 DNMBP sh3 domain of hypothetical protein baa76854.1 -1.0Å AUTH T.NAGATA,Y.MUTO,Y.KAMEWARI,M.SHIROUZU,T.TERADA,AUTH 2 T.KIGAWA,M.INOUE,T.YABUKI,M.AOKI,E.SEKI,T.MATSUDA,AUTH 3 H.HIROTA,M.YOSHIDA,N.KOBAYASHI,A.TANAKA,T.OSANAI,AUTH 4 Y.MATSUO,O.OHARA,T.NAGASE,R.KIKUNO,M.NAKAYAMA,AUTH 5 S.YOKOYAMATITL NMR STRUCTURE OF SH3 DOMAIN OF HYPOTHETICALTITL 2 PROTEIN BAA76854.1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2khn ITSN1 nmr solution structure of the eh 1 domain from human intersectin-1 protein. northeast structural genomics consortium target hr3646e. -1.0Å AUTH J.L.MILLS,A.GHOSH,E.GARCIA,Q.ZHANG,R.SHASTRY,AUTH 2 E.L.FOOTE,H.JANJUA,T.B.ACTON,R.XIAO,J.K.EVERETT,AUTH 3 G.T.MONTELIONE,T.SZYPERSKITITL NMR SOLUTION STRUCTURE OF THE EH 1 DOMAIN FROMTITL 2 HUMAN INTERSECTIN-1 PROTEIN. NORTHEAST STRUCTURALTITL 3 GENOMICS CONSORTIUM TARGET HR3646E.REF TO BE PUBLISHEDREFN Variant Set […]