Assessment of Structural Intolerance and Durability
General Structure Information 4d8k LCK crystal structure of a sh3-sh2 domains of a lymphocyte-specific protein tyrosine kinase (lck) from homo sapiens at 2.36 a resolution 2.36Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGYTITL CRYSTAL STRUCTURE OF A SH3-SH2 DOMAINS OF ATITL 2 LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE (LCK) FROM HOMOTITL 3 […]
General Structure Information 2ebp SASH1 solution structure of the sh3 domain from human sam and sh3 domain containing protein 1 -1.0Å AUTH H.P.ZHANG,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN FROM HUMANTITL 2 SAM AND SH3 DOMAIN CONTAINING PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dl5 FCHSD2 solution structure of the first sh3 domain of human kiaa0769 protein -1.0Å AUTH X.R.QIN,K.IZUMI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST SH3 DOMAIN OFTITL 2 HUMAN KIAA0769 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1x2q STAM2 solution structure of the sh3 domain of the signal transducing adaptor molecule 2 -1.0Å AUTH E.CHIKAYAMA,T.KIGAWA,M.SATO,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF THE SIGNALTITL 2 TRANSDUCING ADAPTOR MOLECULE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kfv TJP3 crystal structure of the sh3-kinase fragment of tight junction protein 3 (tjp3) in apo-form 2.8Å AUTH Y.TONG,L.NEDYALKOVA,W.TEMPEL,N.ZHONG,X.GUAN,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE SH3-KINASE FRAGMENT OFTITL 2 TIGHT JUNCTION PROTEIN 3 (TJP3) IN APO-FORMREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4f14 NEBL structure of the sh3 domain of human nebulette in complex with a peptide of xirp2 1.2Å AUTH S.EULITZ,F.SAUER,M.C.PELISSIER,P.BOISGUERIN,S.MOLT,J.SCHULD,AUTH 2 Z.ORFANOS,R.A.KLEY,R.VOLKMER,M.WILMANNS,G.KIRFEL,AUTH 3 P.F.VAN DER VEN,D.O.FURSTTITL IDENTIFICATION OF XIN-REPEAT PROTEINS AS NOVEL LIGANDS OFTITL 2 THE SH3 DOMAINS OF NEBULIN AND NEBULETTE AND ANALYSIS OFTITL 3 THEIR INTERACTION DURING MYOFIBRIL FORMATION AND […]
General Structure Information 1wx6 NCK2 solution structure of the sh3 domain of the human cytoplasmic protein nck2 -1.0Å AUTH S.OHNISHI,T.KIGAWA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF THE HUMANTITL 2 CYTOPLASMIC PROTEIN NCK2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2csi RIMBP2 solution structure of the third sh3 domain of human rim- binding protein 2 -1.0Å AUTH K.INOUE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD SH3 DOMAIN OFTITL 2 HUMAN RIM-BINDING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3f1i HGS human escrt-0 core complex 2.3Å AUTH X.REN,D.P.KLOER,Y.C.KIM,R.GHIRLANDO,L.F.SAIDI,G.HUMMER,AUTH 2 J.H.HURLEYTITL HYBRID STRUCTURAL MODEL OF THE COMPLETE HUMAN ESCRT-0TITL 2 COMPLEX.REF STRUCTURE V. 17 406 2009REFN ISSN 0969-2126PMID 19278655DOI 10.1016/J.STR.2009.01.012 Variant Set Distributions Mapped Variants
General Structure Information 2jxb NCK2 structure of cd3epsilon-nck2 first sh3 domain complex -1.0Å AUTH K.TAKEUCHI,H.YANG,E.NG,S.Y.PARK,Z.Y.SUN,AUTH 2 E.L.REINHERZ,G.WAGNERTITL STRUCTURAL AND FUNCTIONAL EVIDENCE THAT NCKTITL 2 INTERACTION WITH CD3EPSILON REGULATES T-CELLTITL 3 RECEPTOR ACTIVITY.REF J.MOL.BIOL. V. 380 704 2008REFN ISSN 0022-2836PMID 18555270DOI 10.1016/J.JMB.2008.05.037 Variant Set Distributions Mapped Variants