Assessment of Structural Intolerance and Durability
General Structure Information 1pbw PIK3R1 structure of bcr-homology (bh) domain 2.0Å AUTH A.MUSACCHIO,L.C.CANTLEY,S.C.HARRISONTITL CRYSTAL STRUCTURE OF THE BREAKPOINT CLUSTERTITL 2 REGION-HOMOLOGY DOMAIN FROM PHOSPHOINOSITIDETITL 3 3-KINASE P85 ALPHA SUBUNIT.REF PROC.NATL.ACAD.SCI.USA V. 93 14373 1996REFN ISSN 0027-8424PMID 8962058DOI 10.1073/PNAS.93.25.14373 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2cub NCK1 solution structure of the sh3 domain of the human cytoplasmic protein nck1 -1.0Å AUTH S.OHNISHI,T.KIGAWA,M.SATO,T.TOMIZAWA,S.KOSHIBA,AUTH 2 M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF THE HUMANTITL 2 CYTOPLASMIC PROTEIN NCK1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ky9 VAV1 autoinhibited vav1 2.73Å AUTH B.YU,I.R.MARTINS,P.LI,G.K.AMARASINGHE,J.UMETANI,AUTH 2 M.E.FERNANDEZ-ZAPICO,D.D.BILLADEAU,M.MACHIUS,D.R.TOMCHICK,AUTH 3 M.K.ROSENTITL STRUCTURAL AND ENERGETIC MECHANISMS OF COOPERATIVETITL 2 AUTOINHIBITION AND ACTIVATION OF VAV1REF CELL(CAMBRIDGE,MASS.) V. 140 246 2010REFN ISSN 0092-8674PMID 20141838DOI 10.1016/J.CELL.2009.12.033 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ror VAV1 solution structure of the vav1 sh2 domain complexed with a tyrosine-phosphorylated peptide from slp76 -1.0Å AUTH T.KASAI,M.TANAKA,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE VAV1 SH2 DOMAINTITL 2 COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDETITL 3 FROM SLP76REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3r6n DSP crystal structure of a rigid four spectrin repeat fragment of the human desmoplakin plakin domain 2.95Å AUTH H.J.CHOI,W.I.WEISTITL CRYSTAL STRUCTURE OF A RIGID FOUR-SPECTRIN-REPEAT FRAGMENTTITL 2 OF THE HUMAN DESMOPLAKIN PLAKIN DOMAIN.REF J.MOL.BIOL. V. 409 800 2011REFN ISSN 0022-2836PMID 21536047DOI 10.1016/J.JMB.2011.04.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2rol CD3E structural basis of pxxdy motif recognition in sh3 binding -1.0Å AUTH O.AITIO,M.HELLMAN,T.KESTI,I.KLEINO,O.SAMUILOVA,AUTH 2 K.PAAKKONEN,H.TOSSAVAINEN,K.SAKSELA,P.PERMITITL STRUCTURAL BASIS OF PXXDY MOTIF RECOGNITION IN SH3TITL 2 BINDINGREF J.MOL.BIOL. V. 382 167 2008REFN ISSN 0022-2836PMID 18644376DOI 10.1016/J.JMB.2008.07.008 Variant Set Distributions Mapped Variants
General Structure Information 3lbx SPTB crystal structure of the erythrocyte spectrin tetramerization domain complex 2.8Å AUTH J.J.IPSARO,S.L.HARPER,T.E.MESSICK,R.MARMORSTEIN,A.MONDRAGON,AUTH 2 D.W.SPEICHERTITL CRYSTAL STRUCTURE AND FUNCTIONAL INTERPRETATION OF THETITL 2 ERYTHROCYTE SPECTRIN TETRAMERIZATION DOMAIN COMPLEX.REF BLOOD V. 115 4843 2010REFN ISSN 0006-4971PMID 20197550DOI 10.1182/BLOOD-2010-01-261396 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1w1f LYN sh3 domain of human lyn tyrosine kinase -1.0Å AUTH F.BAUER,K.SCHWEIMER,H.MEISELBACH,S.HOFFMANN,AUTH 2 P.ROESCH,H.STICHTTITL STRUCTURAL CHARACTERIZATION OF LYN-SH3 DOMAIN INTITL 2 COMPLEX WITH A HERPESVIRAL PROTEIN REVEALS ANTITL 3 EXTENDED RECOGNITION MOTIF THAT ENHANCES BINDINGTITL 4 AFFINITY.REF PROTEIN SCI. V. 14 2487 2005REFN ISSN 0961-8368PMID 16155203DOI 10.1110/PS.051563605 Variant Set Distributions Mapped Variants
General Structure Information 2c0o HCK src family kinase hck with bound inhibitor a-770041 2.85Å AUTH A.BURCHAT,D.W.BORHANI,D.J.CALDERWOOD,G.C.HIRST,B.LI,AUTH 2 R.F.STACHLEWITZTITL DISCOVERY OF A-770041, A SRC-FAMILY SELECTIVE ORALLY ACTIVETITL 2 LCK INHIBITOR THAT PREVENTS ORGAN ALLOGRAFT REJECTION.REF BIOORG.MED.CHEM.LETT. V. 16 118 2006REFN ISSN 0960-894XPMID 16216497DOI 10.1016/J.BMCL.2005.09.039 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2zm1 LCK crystal structure of imidazo pyrazin 1 bound to the kinase domain of human lck, (auto-phosphorylated on tyr394) 2.1Å AUTH T.OZAWA,E.TSUJI,M.OZAWA,C.HANDA,H.MUKAIYAMA,AUTH 2 T.NISHIMURA,S.KOBAYASHI,K.OKAZAKITITL THE IMPORTANCE OF CH/PI HYDROGEN BONDS IN RATIONALTITL 2 DRUG DESIGN: AN AB INITIO FRAGMENT MOLECULARTITL 3 ORBITAL STUDY TO LEUKOCYTE-SPECIFIC PROTEINTITL 4 TYROSINE (LCK) KINASEREF BIOORG.MED.CHEM. V. […]