Assessment of Structural Intolerance and Durability
General Structure Information 3tf2 EIF4E crystal structure of the cap free human translation initiation factor eif4e 2.1Å AUTH N.SIDDIQUI,W.TEMPEL,L.NEDYALKOVA,L.VOLPON,A.K.WERNIMONT,AUTH 2 M.J.OSBORNE,H.W.PARK,K.L.BORDENTITL STRUCTURAL INSIGHTS INTO THE ALLOSTERIC EFFECTS OF 4EBP1 ONTITL 2 THE EUKARYOTIC TRANSLATION INITIATION FACTOR EIF4E.REF J.MOL.BIOL. V. 415 781 2012REFN ISSN 0022-2836PMID 22178476DOI 10.1016/J.JMB.2011.12.002 Variant Set Distributions Mapped Variants
General Structure Information 3e04 FH crystal structure of human fumarate hydratase 1.95Å AUTH K.L.KAVANAGH,S.PICAUD,E.S.PILKA,W.W.YUE,A.K.ROOS,AUTH 2 P.FILIPPAKOPOULOS,F.VON DELFT,C.H.ARROWSMITH,M.WIKSTROM,AUTH 3 A.M.EDWARDS,C.BOUNTRA,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF HUMAN FUMARATE HYDRATASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3p1m FDX1 crystal structure of human ferredoxin-1 (fdx1) in complex with iron- sulfur cluster 2.54Å AUTH A.CHAIKUAD,C.JOHANSSON,T.KROJER,W.W.YUE,C.PHILLIPS,J.E.BRAY,AUTH 2 A.C.W.PIKE,J.R.C.MUNIZ,M.VOLLMAR,J.WEIGELT,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,C.BOUNTRA,K.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN FERREDOXIN-1 (FDX1) IN COMPLEXTITL 2 WITH IRON-SULFUR CLUSTERREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3cos ADH4 crystal structure of human class ii alcohol dehydrogenase (adh4) in complex with nad and zn 2.1Å AUTH K.L.KAVANAGH,N.SHAFQAT,W.YUE,F.VON DELFT,S.BISHOP,A.ROOS,AUTH 2 J.MURRAY,A.M.EDWARDS,C.H.ARROWSMITH,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN CLASS II ALCOHOL DEHYDROGENASETITL 2 (ADH4) IN COMPLEX WITH NAD AND ZN.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2iik ACAA1 crystal structure of human peroxisomal acetyl-coa acyl transferase 1 (acaa1) 2.55Å AUTH E.PAPAGRIGORIOU,C.JOHANSSON,C.SMEE,K.KAVANAGH,A.C.W.PIKE,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.EDWARDS,C.H.ARROWSMITH,O.GILEADI,AUTH 3 F.GORREC,C.UMEANO,F.VON DELFT,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF HUMAN PEROXISOMAL ACETYL-COA ACYLTITL 2 TRANSFERASE 1 (ACAA1)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2f8a GPX1 crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1 1.5Å AUTH K.L.KAVANAGH,C.JOHANSSON,C.SMEE,O.GILEADI,F.VON DELFT,AUTH 2 U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE SELENOCYSTEINE TO GLYCINE MUTANT OFTITL 2 HUMAN GLUTATHIONE PEROXIDASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ode GNAI3 crystal structure of the heterodimeric complex of human rgs8 and activated gi alpha 3 1.9Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Mapped Variants
General Structure Information 3tzd HIST1H1E crystal structure of the complex of human chromobox homolog 3 (cbx3) 1.81Å AUTH J.RUAN,H.OUYANG,M.F.AMAYA,M.RAVICHANDRAN,P.LOPPNAU,J.MIN,AUTH 2 J.ZANGTITL STRUCTURAL BASIS OF THE CHROMODOMAIN OF CBX3 BOUND TOTITL 2 METHYLATED PEPTIDES FROM HISTONE H1 AND G9A.REF PLOS ONE V. 7 35376 2012REFN ESSN 1932-6203PMID 22514736DOI 10.1371/JOURNAL.PONE.0035376 Variant Set Distributions Mapped Variants
General Structure Information 3pry HSP90AB1 crystal structure of the middle domain of human hsp90-beta refined at 2.3 a resolution 2.28Å AUTH A.CHAIKUAD,E.PILKA,T.D.SHARPE,C.D.O.COOPER,C.PHILLIPS,AUTH 2 G.BERRIDGE,V.AYINAMPUDI,O.FEDOROV,T.KEATES,AUTH 3 C.THANGARATNARAJAH,T.ZIMMERMANN,M.VOLLMAR,W.W.YUE,K.H.CHE,AUTH 4 T.KROJER,J.R.C.MUNIZ,F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 5 J.WEIGELT,A.EDWARDS,A.BULLOCK,AUTH 6 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE MIDDLE DOMAIN OF HUMAN HSP90-BETATITL 2 REFINED AT 2.3 A RESOLUTIONREF TO BE PUBLISHEDREFN Variant […]
General Structure Information 2p5x ASMTL crystal structure of maf domain of human n-acetylserotonin o- methyltransferase-like protein 2.0Å AUTH A.TCHIGVINTSEV,D.TCHIGVINTSEV,R.FLICK,A.POPOVIC,A.DONG,X.XU,AUTH 2 G.BROWN,W.LU,H.WU,H.CUI,L.DOMBROWSKI,J.C.JOO,N.BELOGLAZOVA,AUTH 3 J.MIN,A.SAVCHENKO,A.A.CAUDY,J.D.RABINOWITZ,A.G.MURZIN,AUTH 4 A.F.YAKUNINTITL BIOCHEMICAL AND STRUCTURAL STUDIES OF CONSERVED MAF PROTEINSTITL 2 REVEALED NUCLEOTIDE PYROPHOSPHATASES WITH A PREFERENCE FORTITL 3 MODIFIED NUCLEOTIDES.REF CHEM.BIOL. V. 20 1386 2013REFN ISSN 1074-5521PMID 24210219DOI 10.1016/J.CHEMBIOL.2013.09.011 Variant Set […]