Assessment of Structural Intolerance and Durability
General Structure Information 3phd UBA52 crystal structure of human hdac6 in complex with ubiquitin 3.0Å AUTH H.OUYANG,Y.O.ALI,M.RAVICHANDRAN,A.DONG,W.QIU,F.MACKENZIE,AUTH 2 S.DHE-PAGANON,C.H.ARROWSMITH,R.G.ZHAITITL PROTEIN AGGREGATES ARE RECRUITED TO AGGRESOME BY HISTONETITL 2 DEACETYLASE 6 VIA UNANCHORED UBIQUITIN C TERMINI.REF J.BIOL.CHEM. V. 287 2317 2012REFN ISSN 0021-9258PMID 22069321DOI 10.1074/JBC.M111.273730 Variant Set Distributions Mapped Variants
General Structure Information 2br9 YWHAE 14-3-3 protein epsilon (human) complexed to peptide 1.75Å AUTH X.YANG,W.H.LEE,F.SOBOTT,E.PAPAGRIGORIOU,C.V.ROBINSON,AUTH 2 J.G.GROSSMANN,M.SUNDSTROM,D.A.DOYLE,J.M.ELKINSTITL STRUCTURAL BASIS FOR PROTEIN-PROTEIN INTERACTIONS IN THETITL 2 14-3-3 PROTEIN FAMILY.REF PROC.NATL.ACAD.SCI.USA V. 103 17237 2006REFN ISSN 0027-8424PMID 17085597DOI 10.1073/PNAS.0605779103 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2qkq EPHB4 structure of the sam domain of human ephrin type-b receptor 4 2.1Å AUTH J.R.WALKER,D.CUERRIER,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL SAM DOMAIN OF HUMAN EPHRIN TYPE-B RECEPTOR 4TITL 2 (EPHB4)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2gl8 RXRG human retinoic acid receptor rxr-gamma ligand-binding domain 2.4Å AUTH A.SCHUETZ,J.R.MIN,P.LOPPNAU,J.WEIGELT,M.SUNDSTROM,AUTH 2 A.M.EDWARDS,C.H.ARROWSMITH,A.BOCHKAREV,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN RETINOIC ACID RECEPTORTITL 2 RXR-GAMMA LIGAND-BINDING DOMAIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2a72 RGS7 structure of the regulator of g-protein signaling domain of rgs7 2.0Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3raw CLK3 crystal structure of human cdc-like kinase 3 isoform in complex with leucettine l41 2.09Å AUTH P.FILIPPAKOPOULOS,O.FEDOROV,O.KING,A.BULLOCK,J.R.C.MUNIZ,AUTH 2 F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,C.BOUNTRA,AUTH 3 S.KNAPP,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF HUMAN CDC-LIKE KINASE 3 ISOFORM WITH ATITL 2 BENZO-DIOXOL LIGANDREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3p1i EPHB3 ligand binding domain of human ephrin type-b receptor 3 2.1Å AUTH J.R.WALKER,L.YERMEKBAYEVA,A.SEITOVA,J.KANIA,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL LIGAND BINDING DOMAIN OF HUMAN EPHB3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2olm AGFG1 arfgap domain of hiv-1 rev binding protein 1.48Å AUTH Y.TONG,W.TEMPEL,L.SHEN,S.DIMOV,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARK,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL ARFGAP DOMAIN OF HIV-1 REV BINDING PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3hm8 HK3 crystal structure of the c-terminal hexokinase domain of human hk3 2.8Å AUTH L.NEDYALKOVA,Y.TONG,W.RABEH,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE C-TERMINAL HEXOKINASE DOMAIN OFTITL 2 HUMAN HK3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2hlz KHK crystal structure of human ketohexokinase (casp target) 1.85Å AUTH W.M.RABEH,W.TEMPEL,L.NEDYALKOVA,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN KETOHEXOKINASE (CASPTITL 2 TARGET)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants