Assessment of Structural Intolerance and Durability
General Structure Information 4drz RAB14 crystal structure of human rab14 2.3Å AUTH J.WANG,W.TEMPEL,C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,AUTH 2 J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB14REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3dlx OXCT1 crystal structure of human 3-oxoacid coa transferase 1 2.2Å AUTH K.L.KAVANAGH,N.SHAFQAT,W.W.YUE,S.PICAUD,J.W.MURRAY,AUTH 2 E.M.MACLEAN,F.VON DELFT,A.K.ROOS,C.H.ARROWSMITH,M.WIKSTROM,AUTH 3 A.M.EDWARDS,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN 3-OXOACID COA TRANSFERASE 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3mtl CDK16 crystal structure of the pctaire1 kinase in complex with indirubin e804 2.4Å AUTH T.KROJER,T.D.SHARPE,A.ROOS,P.SAVITSKY,A.AMOS,V.AYINAMPUDI,AUTH 2 G.BERRIDGE,O.FEDOROV,T.KEATES,C.PHILLIPS,N.BURGESS-BROWN,AUTH 3 Y.ZHANG,A.C.W.PIKE,J.MUNIZ,M.VOLLMAR,C.THANGARATNARAJAH,AUTH 4 P.RELLOS,E.UGOCHUKWU,P.FILIPPAKOPOULOS,W.YUE,S.DAS,AUTH 5 F.VON DELFT,A.EDWARDS,C.H.ARROWSMITH,J.WEIGELT,C.BOUNTRA,AUTH 6 S.KNAPP,A.BULLOCKTITL CRYSTAL STRUCTURE OF THE PCTAIRE1 KINASE IN COMPLEX WITHTITL 2 INDIRUBIN E804REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ery RRAS2 the crystal structure of the ras related protein rras2 (rras2) in the gdp bound state 1.7Å AUTH E.SALAH,G.SCHOCH,A.TURNBULL,E.PAPAGRIGORIOU,M.SOUNDARARAJAN,AUTH 2 N.BURGESS,J.ELKINS,C.GILEADI,O.GILEADI,F.VON DELFT,AUTH 3 A.EDWARDS,C.ARROWSMITH,J.WEIGELT,M.SUNDSTROM,D.DOYLETITL THE CRYSTAL STRUCTURE OF THE RAS RELATED PROTEIN RRAS2TITL 2 (RRAS2) IN THE GDP BOUND STATEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3cpf EIF5A crystal structure of human eukaryotic translation initiation factor eif5a 2.5Å AUTH Y.TONG,I.PARK,B.S.HONG,L.NEDYALKOVA,W.TEMPEL,H.W.PARKTITL CRYSTAL STRUCTURE OF HUMAN EIF5A1: INSIGHT INTO FUNCTIONALTITL 2 SIMILARITY OF HUMAN EIF5A1 AND EIF5A2.REF PROTEINS V. 75 1040 2009REFN ISSN 0887-3585PMID 19280598DOI 10.1002/PROT.22378 Variant Set Distributions Mapped Variants
General Structure Information 3ney MPP1 crystal structure of the kinase domain of mpp1/p55 2.26Å AUTH Y.SHEN,Y.TONG,N.ZHONG,X.GUAN,W.TEMPEL,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF MPP1/P55REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2awf UBE2G1 structure of human ubiquitin-conjugating enzyme e2 g1 2.1Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 2o52 RAB4B crystal structure of human rab4b in complex with gdp 2.2Å AUTH H.ZHU,W.TEMPEL,J.WANG,Y.SHEN,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB4B IN COMPLEX WITHTITL 2 GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ihd RGS8 crystal structure of human regulator of g-protein signaling 8, rgs8 1.7Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2z5d UBE2H human ubiquitin-conjugating enzyme e2 h 2.1Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL.CELL PROTEOMICS V. 11 329 2012REFN ISSN 1535-9476PMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants