Assessment of Structural Intolerance and Durability
General Structure Information 3llm DHX9 crystal structure analysis of a rna helicase 2.8Å AUTH P.SCHUTZ,E.WAHLBERG,T.KARLBERG,M.HAMMARSTROM,R.COLLINS,AUTH 2 A.FLORES,H.SCHULERTITL CRYSTAL STRUCTURE OF HUMAN RNA HELICASE A (DHX9): STRUCTURALTITL 2 BASIS FOR UNSELECTIVE NUCLEOTIDE BASE BINDING IN A DEAD-BOXTITL 3 VARIANT PROTEIN.REF J.MOL.BIOL. V. 400 768 2010REFN ISSN 0022-2836PMID 20510246DOI 10.1016/J.JMB.2010.05.046 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2lll LMNB2 solution nmr structure of c-terminal globular domain of human lamin- b2, northeast structural genomics consortium target hr8546a -1.0Å AUTH A.LEMAK,A.YEE,S.HOULISTON,M.GARCIA,C.XU,J.MIN,AUTH 2 G.T.MONTELIONE,C.ARROWSMITHTITL NMR SOLUTION STRUCTURE OF C-TERMINAL GLOBULAR DOMAIN OFTITL 2 HUMAN LAMIN-B2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lll LMNB2 solution nmr structure of c-terminal globular domain of human lamin- b2, northeast structural genomics consortium target hr8546a -1.0Å AUTH A.LEMAK,A.YEE,S.HOULISTON,M.GARCIA,C.XU,J.MIN,AUTH 2 G.T.MONTELIONE,C.ARROWSMITHTITL NMR SOLUTION STRUCTURE OF C-TERMINAL GLOBULAR DOMAIN OFTITL 2 HUMAN LAMIN-B2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lll LMNB2 solution nmr structure of c-terminal globular domain of human lamin- b2, northeast structural genomics consortium target hr8546a -1.0Å AUTH A.LEMAK,A.YEE,S.HOULISTON,M.GARCIA,C.XU,J.MIN,AUTH 2 G.T.MONTELIONE,C.ARROWSMITHTITL NMR SOLUTION STRUCTURE OF C-TERMINAL GLOBULAR DOMAIN OFTITL 2 HUMAN LAMIN-B2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3i2b PTS the crystal structure of human 6 pyruvoyl tetrahydrobiopterin synthase 2.3Å AUTH E.UGOCHUKWU,R.COCKING,E.PILKA,W.W.YUE,J.E.BRAY,A.CHAIKUAD,AUTH 2 T.KROJER,J.MUNIZ,U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN 6 PYRUVOYLTITL 2 TETRAHYDROBIOPTERIN SYNTHASEREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3uvj GUCY1A3 crystal structure of the catalytic domain of the heterodimeric human soluble guanylate cyclase 1. 2.08Å AUTH C.K.ALLERSTON,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLETITL 2 GUANYLATE CYCLASE.REF PLOS ONE V. 8 57644 2013REFN ESSN 1932-6203PMID 23505436DOI 10.1371/JOURNAL.PONE.0057644 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3ks9 GRM1 metabotropic glutamate receptor mglur1 complexed with ly341495 antagonist 1.9Å AUTH E.DOBROVETSKY,G.KHUTORESKAYA,A.SEITOVA,D.COSSAR,A.M.EDWARDS,AUTH 2 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,A.BOCHKAREVTITL METABOTROPIC GLUTAMATE RECEPTOR MGLUR1 COMPLEXED WITHTITL 2 LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1zsx KCNAB2 crystal structure of human potassium channel kv beta-subunit (kcnab2) 1.9Å AUTH P.WENNERSTRAND,I.JOHANNSSON,E.UGOCHUKWU,K.KAVANAGH,AUTH 2 A.EDWARDS,C.ARROWSMITH,L.WILLIAMS,M.SUNDSTROM,K.GUO,AUTH 3 F.VON DELFT,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN POTASSIUM CHANNEL KV BETA-SUBUNITTITL 2 (KCNAB2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3dm1 CBX3 crystal structure of the complex of human chromobox homolog 3 (cbx3) with peptide 2.4Å AUTH J.RUAN,H.OUYANG,M.F.AMAYA,M.RAVICHANDRAN,P.LOPPNAU,J.MIN,AUTH 2 J.ZANGTITL STRUCTURAL BASIS OF THE CHROMODOMAIN OF CBX3 BOUND TOTITL 2 METHYLATED PEPTIDES FROM HISTONE H1 AND G9A.REF PLOS ONE V. 7 35376 2012REFN ESSN 1932-6203PMID 22514736DOI 10.1371/JOURNAL.PONE.0035376 Variant Set Distributions Mapped Variants
General Structure Information 2fv8 RHOB the crystal structure of rhob in the gdp-bound state 1.9Å AUTH A.P.TURNBULL,M.SOUNDARARAJAN,C.SMEE,C.JOHANSSON,G.SCHOCH,AUTH 2 F.GORREC,J.BRAY,E.PAPAGRIGORIOU,F.VON DELFT,J.WEIGELT,AUTH 3 A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,D.DOYLETITL THE CRYSTAL STRUCTURE OF RHOB IN THE GDP-BOUND STATEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants