Assessment of Structural Intolerance and Durability
General Structure Information 3iq7 GSG2 crystal structure of human haspin in complex with 5-iodotubercidin 2.0Å AUTH J.ESWARAN,D.PATNAIK,P.FILIPPAKOPOULOS,F.WANG,R.L.STEIN,AUTH 2 J.W.MURRAY,J.M.HIGGINS,S.KNAPPTITL STRUCTURE AND FUNCTIONAL CHARACTERIZATION OF THE ATYPICALTITL 2 HUMAN KINASE HASPIN.REF PROC.NATL.ACAD.SCI.USA V. 106 20198 2009REFN ISSN 0027-8424PMID 19918057DOI 10.1073/PNAS.0901989106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2pla GPD1L crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein 2.51Å AUTH J.UPPENBERG,C.SMEE,V.HOZJAN,K.KAVANAGH,G.BUNKOCZI,AUTH 2 E.PAPAGRIGORIOU,A.C.W.PIKE,E.UGOCHUKWU,C.UMEANO,F.VON DELFT,AUTH 3 J.WEIGELT,C.H.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN GLYCEROL-3-PHOSPHATETITL 2 DEHYDROGENASE 1-LIKE PROTEIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2p57 ARFGAP2 gap domain of znf289, an id1-regulated zinc finger protein 1.8Å AUTH Y.TONG,S DIMOV,L.SHEN,H.ZHU,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL GAP DOMAIN OF ZNF289, AN ID1-REGULATED ZINC FINGERTITL 2 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3qik PREX1 crystal structure of the first pdz domain of prex1 2.29Å AUTH L.SHEN,Y.TONG,W.TEMPEL,Y.LI,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF THE FIRST PDZ DOMAIN OF PREX1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3k2j PBRM1 crystal structure of the 3rd bromodomain of human poly-bromodomain containing protein 1 (pb1) 2.2Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,T.KEATES,A.CHAIKUAD,A.C.W.PIKE,AUTH 2 T.KROJER,R.SETHI,F.VON DELFT,C.H.ARROWSMITH,A.EDWARDS,AUTH 3 J.WEIGELT,C.BOUNTRA,S.KNAPPTITL CRYSTAL STRUCTURE OF THE 3RD BROMODOMAIN OF HUMANTITL 2 POLY-BROMODOMAIN CONTAINING PROTEIN 1 (PB1)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2jxx NFATC2IP nmr solution structure of ubiquitin-like domain of nfatc2ip. northeast structural genomics consortium target hr5627 -1.0Å AUTH R.S.DOHERTY,S.DHE-PAGANON,C.FARES,A.LEMAK,C.BUTLER,AUTH 2 S.SRISAILAM,M.KARRA,A.YEE,J.WEIGELT,A.M.EDWARDS,AUTH 3 C.H.ARROWSMITHTITL SOLUTION STRUCTURE OF UBIQUITIN-LIKE DOMAIN OFTITL 2 NFATC2IP.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3n9u CPSF7 crystal structure of the complex between the 25 kda subunit and the 59 kda subunit (rrm domain) of human cleavage factor im 1.92Å AUTH L.TRESAUGUES,M.WELIN,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 M.MOCHE,T.K.NIELSEN,T.NYMAN,C.PERSSON,H.SCHULER,P.SCHUTZ,AUTH 5 M.I.SIPONEN,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,M.WISNIEWSKA,P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE 25 KDA SUBUNITTITL 2 AND THE […]
General Structure Information 2pnt GRASP crystal structure of the pdz domain of human grasp (grp1) in complex with the c-terminal peptide of the metabotropic glutamate receptor type 1 2.15Å AUTH J.ELKINS,E.PAPAGRIGORIOU,C.COOPER,C.GILEADI,AUTH 2 J.UPPENBERG,J.BRAY,F.VON DELFT,A.C.W.PIKE,AUTH 3 E.UGOCHUKWU,C.UMEANO,O.GILEADI,A.EDWARDS,AUTH 4 C.H.ARROWSMITH,J.WEIGELT,M.SUNDSTROM,D.A.DOYLE,AUTH 5 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN GRASPTITL 2 (GRP1) IN […]
General Structure Information 2gk9 PIP4K2C human phosphatidylinositol-4-phosphate 5-kinase, type ii, gamma 2.8Å AUTH A.G.THORSELL,J.UPPENBERG,M.HOGBOM,D.OGG,AUTH 2 C.ARROWSMITH,H.BERGLUND,R.COLLINS,A.EDWARDS,M.EHN,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 4 T.KOTENYOVA,P.NILSSON-EHLE,P.NORDLUND,T.NYMAN,AUTH 5 J.SAGEMARK,P.STENMARK,M.SUNDSTROM,S.VAN DEN BERG,AUTH 6 J.WEIGELT,L.HOLMBERG-SCHIAVONE,C.PERSSON,AUTH 7 B.M.HALLBERGTITL STRUCTURE OF HUMANTITL 2 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE, TYPETITL 3 II, GAMMAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2b0o ASAP3 crystal structure of uplc1 gap domain 2.06Å AUTH S.ISMAIL,L.SHEN,C.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,AUTH 2 J.WEIGELT,A.BOCHKAREV,H.PARKTITL STRUCTURAL ANALYSIS OF GAP AND ANKYRIN DOMAINS OFTITL 2 UPLC1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants