Assessment of Structural Intolerance and Durability
General Structure Information 3u9j FBXL5 crystal structure of oxidized human fbxl5 hemerythrin like domain 1.6Å AUTH C.SHU,M.W.SUNG,M.D.STEWART,T.I.IGUMENOVA,X.TAN,P.LITITL THE STRUCTURAL BASIS OF IRON SENSING BY THE HUMAN F-BOXTITL 2 PROTEIN FBXL5.REF CHEMBIOCHEM V. 13 788 2012REFN ISSN 1439-4227PMID 22492618DOI 10.1002/CBIC.201200043 Variant Set Distributions Mapped Variants
General Structure Information 4iy4 CNNM2 structural and ligand binding properties of the bateman domain of human magnesium transporters cnnm2 and cnnm4 2.9Å AUTH M.A.CORRAL-RODRIGUEZ,M.STUIVER,J.A.ENCINAR,V.SPIWOK,AUTH 2 I.GOMEZ-GARCIA,I.OYENARTE,J.ERENO-ORBEA,H.TERASHIMA,AUTH 3 A.ACCARDI,T.DIERCKS,D.MULLER,L.A.MARTINEZ-CRUZTITL STRUCTURAL AND LIGAND BINDING PROPERTIES OF THE BATEMANTITL 2 DOMAIN OF HUMAN MAGNESIUM TRANSPORTERS CNNM2 AND CNNM4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4lev MB21D1 structure of human cgas 1.95Å AUTH X.LI,C.SHU,G.YI,C.T.CHATON,C.L.SHELTON,J.DIAO,X.ZUO,C.C.KAO,AUTH 2 A.B.HERR,P.LITITL CYCLIC GMP-AMP SYNTHASE IS ACTIVATED BY DOUBLE-STRANDEDTITL 2 DNA-INDUCED OLIGOMERIZATION.REF IMMUNITY V. 39 1019 2013REFN ISSN 1074-7613PMID 24332030DOI 10.1016/J.IMMUNI.2013.10.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4emu TMEM173 crystal structure of ligand free human sting 1.9Å AUTH C.SHU,G.YI,T.WATTS,C.C.KAO,P.LITITL STRUCTURE OF STING BOUND TO CYCLIC DI-GMP REVEALS THETITL 2 MECHANISM OF CYCLIC DINUCLEOTIDE RECOGNITION BY THE IMMUNETITL 3 SYSTEM.REF NAT.STRUCT.MOL.BIOL. V. 19 722 2012REFN ISSN 1545-9993PMID 22728658DOI 10.1038/NSMB.2331 Variant Set Distributions Mapped Variants
General Structure Information 4h22 LRRFIP1 crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor lrrfip1 2.89Å AUTH J.B.NGUYEN,Y.MODISTITL CRYSTAL STRUCTURE OF THE DIMERIC COILED-COIL DOMAIN OF THETITL 2 CYTOSOLIC NUCLEIC ACID SENSOR LRRFIP1.REF J.STRUCT.BIOL. V. 181 82 2013REFN ISSN 1047-8477PMID 23099021DOI 10.1016/J.JSB.2012.10.006 Variant Set Distributions Mapped Variants
General Structure Information 4n5x SLC25A24 crystal structure of n-terminal calmodulin-like calcium sensor of human mitochondrial atp-mg/pi carrier scamc1 2.1Å AUTH Q.YANG,S.BRUSCHWEILER,J.J.CHOUTITL A SELF-SEQUESTERED CALMODULIN-LIKE CA(2+) SENSOR OFTITL 2 MITOCHONDRIAL SCAMC CARRIER AND ITS IMPLICATION TOTITL 3 CA(2+)-DEPENDENT ATP-MG/PI TRANSPORT.REF STRUCTURE V. 22 209 2014REFN ISSN 0969-2126PMID 24332718DOI 10.1016/J.STR.2013.10.018 Variant Set Distributions Mapped Variants
General Structure Information 2k60 STIM1 nmr structure of calcium-loaded stim1 ef-sam -1.0Å AUTH P.B.STATHOPULOS,L.ZHENG,G.Y.LI,M.J.PLEVIN,M.IKURATITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO STIM1-MEDIATEDTITL 2 INITIATION OF STORE-OPERATED CALCIUM ENTRY.REF CELL(CAMBRIDGE,MASS.) V. 135 110 2008REFN ISSN 0092-8674PMID 18854159DOI 10.1016/J.CELL.2008.08.006 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4l7d KEAP1 structure of keap1 kelch domain with (1s,2r)-2-{[(1s)-5-methyl-1-[(1- oxo-1,3-dihydro-2h-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin- 2(1h)-yl]carbonyl}cyclohexanecarboxylic acid 2.25Å AUTH E.JNOFF,C.ALBRECHT,J.J.BARKER,O.BARKER,E.BEAUMONT,AUTH 2 S.BROMIDGE,F.BROOKFIELD,M.BROOKS,C.BUBERT,T.CESKA,V.CORDEN,AUTH 3 G.DAWSON,S.DUCLOS,T.FRYATT,C.GENICOT,E.JIGOREL,J.KWONG,AUTH 4 R.MAGHAMES,I.MUSHI,R.PIKE,Z.A.SANDS,M.A.SMITH,C.C.STIMSON,AUTH 5 J.P.COURADETITL BINDING MODE AND STRUCTURE-ACTIVITY RELATIONSHIPS AROUNDTITL 2 DIRECT INHIBITORS OF THE NRF2-KEAP1 COMPLEX.REF CHEMMEDCHEM V. 9 699 2014REFN ISSN 1860-7179PMID 24504667DOI 10.1002/CMDC.201300525 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4l7d KEAP1 structure of keap1 kelch domain with (1s,2r)-2-{[(1s)-5-methyl-1-[(1- oxo-1,3-dihydro-2h-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin- 2(1h)-yl]carbonyl}cyclohexanecarboxylic acid 2.25Å AUTH E.JNOFF,C.ALBRECHT,J.J.BARKER,O.BARKER,E.BEAUMONT,AUTH 2 S.BROMIDGE,F.BROOKFIELD,M.BROOKS,C.BUBERT,T.CESKA,V.CORDEN,AUTH 3 G.DAWSON,S.DUCLOS,T.FRYATT,C.GENICOT,E.JIGOREL,J.KWONG,AUTH 4 R.MAGHAMES,I.MUSHI,R.PIKE,Z.A.SANDS,M.A.SMITH,C.C.STIMSON,AUTH 5 J.P.COURADETITL BINDING MODE AND STRUCTURE-ACTIVITY RELATIONSHIPS AROUNDTITL 2 DIRECT INHIBITORS OF THE NRF2-KEAP1 COMPLEX.REF CHEMMEDCHEM V. 9 699 2014REFN ISSN 1860-7179PMID 24504667DOI 10.1002/CMDC.201300525 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4l7d KEAP1 structure of keap1 kelch domain with (1s,2r)-2-{[(1s)-5-methyl-1-[(1- oxo-1,3-dihydro-2h-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin- 2(1h)-yl]carbonyl}cyclohexanecarboxylic acid 2.25Å AUTH E.JNOFF,C.ALBRECHT,J.J.BARKER,O.BARKER,E.BEAUMONT,AUTH 2 S.BROMIDGE,F.BROOKFIELD,M.BROOKS,C.BUBERT,T.CESKA,V.CORDEN,AUTH 3 G.DAWSON,S.DUCLOS,T.FRYATT,C.GENICOT,E.JIGOREL,J.KWONG,AUTH 4 R.MAGHAMES,I.MUSHI,R.PIKE,Z.A.SANDS,M.A.SMITH,C.C.STIMSON,AUTH 5 J.P.COURADETITL BINDING MODE AND STRUCTURE-ACTIVITY RELATIONSHIPS AROUNDTITL 2 DIRECT INHIBITORS OF THE NRF2-KEAP1 COMPLEX.REF CHEMMEDCHEM V. 9 699 2014REFN ISSN 1860-7179PMID 24504667DOI 10.1002/CMDC.201300525 Variant Set Distributions Ripley’s K Analysis Plots […]