Assessment of Structural Intolerance and Durability
General Structure Information 2rb4 DDX25 crystal structure of the helicase domain of human ddx25 rna helicase 2.8Å AUTH P.SCHUTZ,T.KARLBERG,S.VAN DEN BERG,R.COLLINS,L.LEHTIO,AUTH 2 M.HOGBOM,L.HOLMBERG-SCHIAVONE,W.TEMPEL,H.W.PARK,AUTH 3 M.HAMMARSTROM,M.MOCHE,A.G.THORSELL,H.SCHULERTITL COMPARATIVE STRUCTURAL ANALYSIS OF HUMAN DEAD-BOX RNATITL 2 HELICASES.REF PLOS ONE V. 5 12791 2010REFN ESSN 1932-6203PMID 20941364DOI 10.1371/JOURNAL.PONE.0012791 Variant Set Distributions Mapped Variants
General Structure Information 3n2n ANTXR1 the crystal structure of tumor endothelial marker 8 (tem8) extracellular domain 1.8Å AUTH S.FU,X.TONG,C.CAI,Y.ZHAO,Y.WU,Y.LI,J.XU,X.C.ZHANG,L.XU,AUTH 2 W.CHEN,Z.RAOTITL THE STRUCTURE OF TUMOR ENDOTHELIAL MARKER 8 (TEM8)TITL 2 EXTRACELLULAR DOMAIN AND IMPLICATIONS FOR ITS RECEPTORTITL 3 FUNCTION FOR RECOGNIZING ANTHRAX TOXIN.REF PLOS ONE V. 5 E1120 2010REFN ESSN 1932-6203PMID 20585457DOI 10.1371/JOURNAL.PONE.0011203 Variant Set […]
General Structure Information 1u7t HSD17B10 crystal structure of abad/hsd10 with a bound inhibitor 2.0Å AUTH C.R.KISSINGER,P.A.REJTO,L.A.PELLETIER,J.A.THOMSON,AUTH 2 R.E.SHOWALTER,M.A.ABREO,C.S.AGREE,S.MARGOSIAK,AUTH 3 J.J.MENG,R.M.AUST,D.VANDERPOOL,B.LI,AUTH 4 A.TEMPCZYK-RUSSELL,J.E.VILLAFRANCATITL CRYSTAL STRUCTURE OF HUMAN ABAD/HSD10 WITH A BOUNDTITL 2 INHIBITOR: IMPLICATIONS FOR DESIGN OF ALZHEIMERSTITL 3 DISEASE THERAPEUTICSREF J.MOL.BIOL. V. 342 943 2004REFN ISSN 0022-2836PMID 15342248DOI 10.1016/J.JMB.2004.07.071 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3h8v UBA5 human ubiquitin-activating enzyme 5 in complex with atp 2.0Å AUTH J.P.BACIK,J.R.WALKER,M.ALI,A.D.SCHIMMER,S.DHE-PAGANONTITL CRYSTAL STRUCTURE OF THE HUMAN UBIQUITIN-ACTIVATING ENZYME 5TITL 2 (UBA5) BOUND TO ATP: MECHANISTIC INSIGHTS INTO ATITL 3 MINIMALISTIC E1 ENZYME.REF J.BIOL.CHEM. V. 285 20273 2010REFN ISSN 0021-9258PMID 20368332DOI 10.1074/JBC.M110.102921 Variant Set Distributions Mapped Variants
General Structure Information 2i3b NTPCR solution structure of a human cancer-related nucleoside triphosphatase -1.0Å AUTH W.J.PLACZEK,M.S.ALMEIDA,K.WUTHRICHTITL NMR STRUCTURE AND FUNCTIONAL CHARACTERIZATION OF ATITL 2 HUMAN CANCER-RELATED NUCLEOSIDE TRIPHOSPHATASE.REF J.MOL.BIOL. V. 367 788 2007REFN ISSN 0022-2836PMID 17291528DOI 10.1016/J.JMB.2007.01.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2d7r GALNT10 crystal structure of pp-galnac-t10 complexed with galnac-ser on lectin domain 2.8Å AUTH T.KUBOTA,T.SHIBA,S.SUGIOKA,S.FURUKAWA,H.SAWAKI,R.KATO,AUTH 2 S.WAKATSUKI,H.NARIMATSUTITL STRUCTURAL BASIS OF CARBOHYDRATE TRANSFER ACTIVITY BY HUMANTITL 2 UDP-GALNAC: POLYPEPTIDETITL 3 ALPHA-N-ACETYLGALACTOSAMINYLTRANSFERASE (PP-GALNAC-T10)REF J.MOL.BIOL. V. 359 708 2006REFN ISSN 0022-2836PMID 16650853DOI 10.1016/J.JMB.2006.03.061 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2zb7 PTGR2 crystal structure of human 15-ketoprostaglandin delta-13- reductase in complex with nadph and nicotinamide 1.8Å AUTH Y.H.WU,T.P.KO,R.T.GUO,S.M.HU,L.M.CHUANG,A.H.J.WANGTITL STRUCTURAL BASIS FOR CATALYTIC AND INHIBITORYTITL 2 MECHANISMS OF HUMAN PROSTAGLANDIN REDUCTASE PTGR2.REF STRUCTURE V. 16 1714 2008REFN ISSN 0969-2126PMID 19000823DOI 10.1016/J.STR.2008.09.007 Variant Set Distributions Mapped Variants
General Structure Information 3pkj SIRT6 human sirt6 crystal structure in complex with 2-n-acetyl adp ribose 2.12Å AUTH P.W.PAN,A.DONG,J.MIN,C.ARROWSMITH,A.EDWARDSTITL HUMAN SIRT6 CRYSTAL STRUCTURE IN COMPLEX WITH 2-N-ACETYLTITL 2 ADP RIBOSEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3qj4 RNLS crystal structure of human renalase (isoform 1) 2.5Å AUTH M.MILANI,F.CIRIELLO,S.BARONI,V.PANDINI,G.CANEVARI,AUTH 2 M.BOLOGNESI,A.ALIVERTITITL FAD-BINDING SITE AND NADP REACTIVITY IN HUMAN RENALASE: ATITL 2 NEW ENZYME INVOLVED IN BLOOD PRESSURE REGULATIONREF J.MOL.BIOL. V. 411 463 2011REFN ISSN 0022-2836PMID 21699903DOI 10.1016/J.JMB.2011.06.010 Variant Set Distributions Mapped Variants
General Structure Information 3r2w UGP2 crystal strucutre of udp-glucose pyrophosphorylase of homo sapiens 3.6Å AUTH Q.YU,X.ZHENGTITL THE CRYSTAL STRUCTURE OF HUMAN UDP-GLUCOSE PYROPHOSPHORYLASETITL 2 REVEALS A LATCH EFFECT THAT INFLUENCES ENZYMATIC ACTIVITY.REF BIOCHEM.J. V. 442 283 2012REFN ISSN 0264-6021PMID 22132858DOI 10.1042/BJ20111598 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]