Assessment of Structural Intolerance and Durability
General Structure Information 3bwy COMT crystal structure of human 108m catechol o- methyltransferase bound with s-adenosylmethionine and inhibitor dinitrocatechol 1.3Å AUTH K.RUTHERFORD,I.LE TRONG,R.E.STENKAMP,W.W.PARSONTITL CRYSTAL STRUCTURES OF HUMAN 108V AND 108M CATECHOLTITL 2 O-METHYLTRANSFERASE.REF J.MOL.BIOL. V. 380 120 2008REFN ISSN 0022-2836PMID 18486144DOI 10.1016/J.JMB.2008.04.040 Variant Set Distributions Mapped Variants
General Structure Information 1h66 NQO1 crystal structure of human nad[p]h-quinone oxidoreductase co with 2,5-diaziridinyl-3-hydroxyl-6-methyl-1,4-benzoquinone 2.0Å AUTH M.FAIG,M.A.BIANCHET,S.WINSKI,R.HARGREAVES,C.J.MOODY,AUTH 2 A.R.HUDNOTT,D.ROSS,L.M.AMZELTITL STRUCTURE-BASED DEVELOPMENT OF ANTICANCER DRUGS: COMPLEXESTITL 2 OF NAD(P)H:QUINONE OXIDOREDUCTASE 1 WITH CHEMOTHERAPEUTICTITL 3 QUINONESREF STRUCTURE V. 9 659 2001REFN ISSN 0969-2126PMID 11587640DOI 10.1016/S0969-2126(01)00636-0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1dig MTHFD1 human methylenetetrahydrofolate dehydrogenase / cyclohydrolase complexed with nadp and inhibitor ly374571 2.2Å AUTH A.SCHMIDT,H.WU,R.E.MACKENZIE,V.J.CHEN,J.R.BEWLY,AUTH 2 J.E.RAY,J.E.TOTH,M.CYGLERTITL STRUCTURES OF THREE INHIBITOR COMPLEXES PROVIDETITL 2 INSIGHT INTO THE REACTION MECHANISM OF THE HUMANTITL 3 METHYLENETETRAHYDROFOLATETITL 4 DEHYDROGENASE/CYCLOHYDROLASE.REF BIOCHEMISTRY V. 39 6325 2000REFN ISSN 0006-2960PMID 10828945DOI 10.1021/BI992734Y Variant Set Distributions Mapped Variants
General Structure Information 3vi4 ITGA5 crystal structure of alpha5beta1 integrin headpiece in complex with rgd peptide 2.9Å AUTH M.NAGAE,S.RE,E.MIHARA,T.NOGI,Y.SUGITA,J.TAKAGITITL CRYSTAL STRUCTURE OF ALPHA5BETA1 INTEGRIN ECTODOMAIN: ATOMICTITL 2 DETAILS OF THE FIBRONECTIN RECEPTORREF J.CELL BIOL. V. 197 131 2012REFN ISSN 0021-9525PMID 22451694DOI 10.1083/JCB.201111077 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3fcs ITGA2B structure of complete ectodomain of integrin aiibb3 2.55Å AUTH J.ZHU,B.H.LUO,T.XIAO,C.ZHANG,N.NISHIDA,T.A.SPRINGERTITL STRUCTURE OF A COMPLETE INTEGRIN ECTODOMAIN IN A PHYSIOLOGICTITL 2 RESTING STATE AND ACTIVATION AND DEACTIVATION BY APPLIEDTITL 3 FORCES.REF MOL.CELL V. 32 849 2008REFN ISSN 1097-2765PMID 19111664DOI 10.1016/J.MOLCEL.2008.11.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4f0i NTRK1 crystal structure of apo trka 2.3Å AUTH T.BERTRAND,M.KOTHE,J.LIU,A.DUPUY,A.RAK,P.F.BERNE,S.DAVIS,AUTH 2 T.GLADYSHEVA,C.VALTRE,J.Y.CRENNE,M.MATHIEUTITL THE CRYSTAL STRUCTURES OF TRKA AND TRKB SUGGEST KEY REGIONSTITL 2 FOR ACHIEVING SELECTIVE INHIBITION.REF J.MOL.BIOL. V. 423 439 2012REFN ISSN 0022-2836PMID 22902478DOI 10.1016/J.JMB.2012.08.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3vi3 ITGB1 crystal structure of alpha5beta1 integrin headpiece (ligand-free form) 2.9Å AUTH M.NAGAE,S.RE,E.MIHARA,T.NOGI,Y.SUGITA,J.TAKAGITITL CRYSTAL STRUCTURE OF ALPHA5BETA1 INTEGRIN ECTODOMAIN: ATOMICTITL 2 DETAILS OF THE FIBRONECTIN RECEPTORREF J.CELL BIOL. V. 197 131 2012REFN ISSN 0021-9525PMID 22451694DOI 10.1083/JCB.201111077 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1znq GAPDH crsytal structure of human liver gapdh 2.5Å AUTH S.A.ISMAIL,H.W.PARKTITL CRYSTAL STRUCTURE ANALYSIS OF HUMAN LIVER GAPDHREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1t0l IDH1 crystal structure of human cytosolic nadp(+)-dependent isocitrate dehydrogenase in complex with nadp, isocitrate, and calcium(2+) 2.41Å AUTH X.XU,J.ZHAO,Z.XU,B.PENG,Q.HUANG,E.ARNOLD,J.DINGTITL STRUCTURES OF HUMAN CYTOSOLIC NADP-DEPENDENTTITL 2 ISOCITRATE DEHYDROGENASE REVEAL A NOVELTITL 3 SELF-REGULATORY MECHANISM OF ACTIVITYREF J.BIOL.CHEM. V. 279 33946 2004REFN ISSN 0021-9258PMID 15173171DOI 10.1074/JBC.M404298200 Variant Set Distributions Ripley’s K Analysis Plots […]