Assessment of Structural Intolerance and Durability
General Structure Information 3nr1 HDDC3 a metazoan ortholog of spot hydrolyzes ppgpp and plays a role in starvation responses 1.9Å AUTH D.W.SUN,G.LEE,J.H.LEE,H.Y.KIM,H.W.RHEE,S.Y.PARK,K.J.KIM,AUTH 2 Y.KIM,B.Y.KIM,J.I.HONG,C.PARK,H.E.CHOY,J.H.KIM,Y.H.JEON,AUTH 3 J.CHUNGTITL A METAZOAN ORTHOLOG OF SPOT HYDROLYZES PPGPP AND FUNCTIONSTITL 2 IN STARVATION RESPONSESREF NAT.STRUCT.MOL.BIOL. V. 17 1188 2010REFN ISSN 1545-9993PMID 20818390DOI 10.1038/NSMB.1906 Variant Set Distributions Mapped Variants
General Structure Information 3kgr LAIR1 crystal structure of the human leukocyte-associated ig-like receptor-1 (lair-1) 1.8Å AUTH T.H.C.BRONDIJK,T.DE RUITER,J.BALLERING,H.WIENK,R.J.LEBBINK,AUTH 2 H.VAN INGEN,R.BOELENS,R.W.FARNDALE,L.MEYAARD,E.G.HUIZINGATITL CRYSTAL STRUCTURE AND COLLAGEN-BINDING SITE OF IMMUNETITL 2 INHIBITORY RECEPTOR LAIR-1: UNEXPECTED IMPLICATIONS FORTITL 3 COLLAGEN BINDING BY PLATELET RECEPTOR GPVIREF BLOOD V. 115 1364 2010REFN ISSN 0006-4971PMID 20007810DOI 10.1182/BLOOD-2009-10-246322 Variant Set Distributions Ripley’s […]
General Structure Information 3ecs EIF2B1 crystal structure of human eif2b alpha 2.65Å AUTH T.B.HIYAMA,T.ITO,H.IMATAKA,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT OF HUMAN TRANSLATIONTITL 2 INITIATION FACTOR 2BREF J.MOL.BIOL. V. 392 937 2009REFN ISSN 0022-2836PMID 19631657DOI 10.1016/J.JMB.2009.07.054 Variant Set Distributions Mapped Variants
General Structure Information 2z7x TLR1 crystal structure of the tlr1-tlr2 heterodimer induced by binding of a tri-acylated lipopeptide 2.1Å AUTH M.S.JIN,S.E.KIM,J.Y.HEO,M.E.LEE,H.M.KIM,S.G.PAIK,H.LEE,AUTH 2 J.O.LEETITL CRYSTAL STRUCTURE OF THE TLR1-TLR2 HETERODIMER INDUCED BYTITL 2 BINDING OF A TRI-ACYLATED LIPOPEPTIDEREF CELL(CAMBRIDGE,MASS.) V. 130 1071 2007REFN ISSN 0092-8674PMID 17889651DOI 10.1016/J.CELL.2007.09.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3k05 MDC1 the crystal structure of mdc1 brct t2067d in complex with a minimal recognition tetrapeptide with an amidated c-terminus 1.33Å AUTH S.J.CAMPBELL,R.A.EDWARDS,J.N.GLOVERTITL COMPARISON OF THE STRUCTURES AND PEPTIDE BINDINGTITL 2 SPECIFICITIES OF THE BRCT DOMAINS OF MDC1 AND BRCA1REF STRUCTURE V. 18 167 2010REFN ISSN 0969-2126PMID 20159462DOI 10.1016/J.STR.2009.12.008 Variant Set Distributions […]
General Structure Information 1uv0 REG3A pancreatitis-associated protein 1 from human 1.78Å AUTH C.ABERGEL,S.CHENIVESSE,M.G.STINNAKRE,S.GUASCO,C.BRECHOT,AUTH 2 J.M.CLAVERIE,E.DEVINOY,L.CHRISTATITL CRYSTALLIZATION AND PRELIMINARY CRYSTALLOGRAPHIC STUDY OFTITL 2 HIP/PAP, A HUMAN C-LECTIN OVEREXPRESSED IN PRIMARY LIVERTITL 3 CANCERS.REF ACTA CRYSTALLOGR.,SECT.D V. 55 1487 1999REFN ISSN 0907-4449PMID 10417404 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4oav RNASEL complete human rnase l in complex with 2-5a (5-ppp heptamer), amppcp and rna substrate. 2.1Å AUTH Y.HAN,J.DONOVAN,S.RATH,G.WHITNEY,A.CHITRAKAR,A.KORENNYKHTITL STRUCTURE OF HUMAN RNASE L REVEALS THE BASIS FOR REGULATEDTITL 2 RNA DECAY IN THE IFN RESPONSE.REF SCIENCE V. 343 1244 2014REFN ISSN 0036-8075PMID 24578532DOI 10.1126/SCIENCE.1249845 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2y4t DNAJC3 crystal structure of the human co-chaperone p58(ipk) 3.0Å AUTH M.SVARD,E.I.BITEROVA,J.-M.BOURHIS,J.E.GUYTITL THE CRYSTAL STRUCTURE OF THE HUMAN CO-CHAPERONE P58IPKREF PLOS ONE V. 6 22337 2011REFN ISSN 1932-6203PMID 21799829DOI 10.1371/JOURNAL.PONE.0022337 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2epa KLF10 solution structure of the first and second zf-c2h2 domains from human krueppel-like factor 10 -1.0Å AUTH K.IZUMI,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST AND SECOND ZF-C2H2TITL 2 DOMAINS FROM HUMAN KRUEPPEL-LIKE FACTOR 10REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1a3q NFKB2 human nf-kappa-b p52 bound to dna 2.1Å AUTH P.CRAMER,C.J.LARSON,G.L.VERDINE,C.W.MULLERTITL STRUCTURE OF THE HUMAN NF-KAPPAB P52 HOMODIMER-DNATITL 2 COMPLEX AT 2.1 A RESOLUTION.REF EMBO J. V. 16 7078 1997REFN ISSN 0261-4189PMID 9384586DOI 10.1093/EMBOJ/16.23.7078 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants