Assessment of Structural Intolerance and Durability
General Structure Information 3ljw PBRM1 crystal structure of the second bromodomain of human polybromo 1.5Å AUTH Z.CHARLOP-POWERS,L.ZENG,Q.ZHANG,M.M.ZHOUTITL STRUCTURAL INSIGHTS INTO SELECTIVE HISTONE H3 RECOGNITIONTITL 2 BY THE HUMAN POLYBROMO BROMODOMAIN 2.REF CELL RES. V. 20 529 2010REFN ISSN 1001-0602PMID 20368734DOI 10.1038/CR.2010.43 Variant Set Distributions Mapped Variants
General Structure Information 3ob9 MSL3 structure of the human msl3 chromo-barrel domain at 2.5 angstrom resolution 2.5Å AUTH S.A.MOORE,Y.FERHATOGLUTITL STRUCTURE OF THE HUMAN MSL3 CHROMO-BARREL DOMAIN AT 2.5TITL 2 ANGSTROM RESOLUTIONREF J.BIOL.CHEM. 2010REFN ESSN 1083-351X Variant Set Distributions Mapped Variants
General Structure Information 4k6j WAPAL human cohesin inhibitor wapl 2.62Å AUTH Z.OUYANG,G.ZHENG,J.SONG,D.M.BOREK,Z.OTWINOWSKI,AUTH 2 C.A.BRAUTIGAM,D.R.TOMCHICK,S.RANKIN,H.YUTITL STRUCTURE OF THE HUMAN COHESIN INHIBITOR WAPL.REF PROC.NATL.ACAD.SCI.USA V. 110 11355 2013REFN ISSN 0027-8424PMID 23776203DOI 10.1073/PNAS.1304594110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4hpl BCOR pcgf1 ub fold (rawul)/bcor pufd complex 2.0Å AUTH S.E.JUNCO,R.WANG,J.C.GAIPA,A.B.TAYLOR,V.SCHIRF,M.D.GEARHART,AUTH 2 V.J.BARDWELL,B.DEMELER,P.J.HART,C.A.KIMTITL STRUCTURE OF THE POLYCOMB GROUP PROTEIN PCGF1 IN COMPLEXTITL 2 WITH BCOR REVEALS BASIS FOR BINDING SELECTIVITY OF PCGFTITL 3 HOMOLOGS.REF STRUCTURE V. 21 665 2013REFN ISSN 0969-2126PMID 23523425DOI 10.1016/J.STR.2013.02.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2rfj BRDT crystal structure of the bromo domain 1 in human bromodomain containing protein, testis specific (brdt) 2.05Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3k9j SETMAR transposase domain of metnase 1.9Å AUTH K.D.GOODWIN,H.HE,T.IMASAKI,S.H.LEE,M.M.GEORGIADISTITL CRYSTAL STRUCTURE OF THE HUMAN HSMAR1-DERIVED TRANSPOSASETITL 2 DOMAIN IN THE DNA REPAIR ENZYME METNASE.REF BIOCHEMISTRY V. 49 5705 2010REFN ISSN 0006-2960PMID 20521842DOI 10.1021/BI100171X Variant Set Distributions Mapped Variants
General Structure Information 4hpm BCORL1 pcgf1 ub fold (rawul)/bcorl1 pufd complex 1.85Å AUTH S.E.JUNCO,R.WANG,J.C.GAIPA,A.B.TAYLOR,V.SCHIRF,M.D.GEARHART,AUTH 2 V.J.BARDWELL,B.DEMELER,P.J.HART,C.A.KIMTITL STRUCTURE OF THE POLYCOMB GROUP PROTEIN PCGF1 IN COMPLEXTITL 2 WITH BCOR REVEALS BASIS FOR BINDING SELECTIVITY OF PCGFTITL 3 HOMOLOGS.REF STRUCTURE V. 21 665 2013REFN ISSN 0969-2126PMID 23523425DOI 10.1016/J.STR.2013.02.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3bo5 SETMAR crystal structure of methyltransferase domain of human histone-lysine n-methyltransferase setmar 1.59Å AUTH H.WU,V.V.LUNIN,H.REN,E.DOBROVETSKY,J.WEIGELT,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,J.MIN,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMANTITL 2 HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR IN COMPLEX WITHTITL 3 ADOHCY.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2kr0 ADRM1 a proteasome protein -1.0Å AUTH X.CHEN,B.H.LEE,D.FINLEY,K.J.WALTERSTITL STRUCTURE OF PROTEASOME UBIQUITIN RECEPTOR HRPN13 AND ITSTITL 2 ACTIVATION BY THE SCAFFOLDING PROTEIN HRPN2.REF MOL.CELL V. 38 404 2010REFN ISSN 1097-2765PMID 20471946DOI 10.1016/J.MOLCEL.2010.04.019 Variant Set Distributions Mapped Variants
General Structure Information 3cfv RBBP7 structural basis of the interaction of rbap46/rbap48 with histone h4 2.6Å AUTH N.V.MURZINA,X.Y.PEI,W.ZHANG,M.SPARKES,AUTH 2 J.VICENTE-GARCIA,J.V.PRATAP,S.H.MCLAUGHLIN,AUTH 3 T.R.BEN-SHAHAR,A.VERREAULT,B.F.LUISI,E.D.LAUETITL STRUCTURAL BASIS FOR THE RECOGNITION OF HISTONE H4TITL 2 BY THE HISTONE-CHAPERONE RBAP46.REF STRUCTURE V. 16 1077 2008REFN ISSN 0969-2126PMID 18571423DOI 10.1016/J.STR.2008.05.006 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]