Assessment of Structural Intolerance and Durability
General Structure Information 3w3g TLR8 crystal structure of human tlr8 (unliganded form) 2.3Å AUTH H.TANJI,U.OHTO,T.SHIBATA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL REORGANIZATION OF THE TOLL-LIKE RECEPTOR 8 DIMERTITL 2 INDUCED BY AGONISTIC LIGANDSREF SCIENCE V. 339 1426 2013REFN ISSN 0036-8075PMID 23520111DOI 10.1126/SCIENCE.1229159 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3c5h ARHGAP35 crystal structure of the ras homolog domain of human grlf1 (p190rhogap) 1.8Å AUTH L.SHEN,Y.TONG,W.TEMPEL,F.MACKENZIE,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RAS HOMOLOG DOMAIN OFTITL 2 HUMAN GRLF1 (P190RHOGAP).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3tgx IL21R il-21:il21r complex 2.8Å AUTH O.J.HAMMING,L.KANG,A.SVENSSON,J.L.KARLSEN,H.RAHBEK-NIELSEN,AUTH 2 S.R.PALUDAN,S.A.HJORTH,K.BONDENSGAARD,R.HARTMANNTITL THE CRYSTAL STRUCTURE OF THE INTERLEUKIN 21 RECEPTOR BOUNDTITL 2 TO INTERLEUKIN 21 REVEALS THAT A SUGAR CHAIN INTERACTINGTITL 3 WITH THE WSXWS MOTIF IS AN INTEGRAL PART OF THE INTERLEUKINTITL 4 21 RECEPTOR.REF J.BIOL.CHEM. 2012REFN ESSN 1083-351XPMID 22235133DOI 10.1074/JBC.M111.311084 Variant Set Distributions […]
General Structure Information 3tgx IL21 il-21:il21r complex 2.8Å AUTH O.J.HAMMING,L.KANG,A.SVENSSON,J.L.KARLSEN,H.RAHBEK-NIELSEN,AUTH 2 S.R.PALUDAN,S.A.HJORTH,K.BONDENSGAARD,R.HARTMANNTITL THE CRYSTAL STRUCTURE OF THE INTERLEUKIN 21 RECEPTOR BOUNDTITL 2 TO INTERLEUKIN 21 REVEALS THAT A SUGAR CHAIN INTERACTINGTITL 3 WITH THE WSXWS MOTIF IS AN INTEGRAL PART OF THE INTERLEUKINTITL 4 21 RECEPTOR.REF J.BIOL.CHEM. 2012REFN ESSN 1083-351XPMID 22235133DOI 10.1074/JBC.M111.311084 Variant Set Distributions […]
General Structure Information 4kt1 LGR4 complex of r-spondin 1 with lgr4 extracellular domain 2.5Å AUTH D.L.WANG,B.HUANG,S.ZHANG,X.YU,W.WU,X.Q.WANGTITL STRUCTURAL BASIS FOR R-SPONDIN RECOGNITION BY LGR4/5/6TITL 2 RECEPTORSREF GENES DEV. V. 27 1339 2013REFN ISSN 0890-9369PMID 23756652DOI 10.1101/GAD.219360.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dlq IL22 crystal structure of the il-22/il-22r1 complex 1.9Å AUTH L.BLEICHER,P.R.DE MOURA,L.WATANABE,D.COLAU,AUTH 2 L.DUMOUTIER,J.-C.RENAULD,I.POLIKARPOVTITL CRYSTAL STRUCTURE OF THE IL-22/IL-22R1 COMPLEX ANDTITL 2 ITS IMPLICATIONS FOR THE IL-22 SIGNALING MECHANISMREF FEBS LETT. V. 582 2985 2008REFN ISSN 0014-5793PMID 18675809DOI 10.1016/J.FEBSLET.2008.07.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4frw PVRL4 crystal structure of human nectin-4 extracellular fragment d1-d2 3.5Å AUTH O.J.HARRISON,J.VENDOME,J.BRASCH,X.JIN,S.HONG,P.S.KATSAMBA,AUTH 2 G.AHLSEN,R.B.TROYANOVSKY,S.M.TROYANOVSKY,B.HONIG,L.SHAPIROTITL NECTIN ECTODOMAIN STRUCTURES REVEAL A CANONICAL ADHESIVETITL 2 INTERFACE.REF NAT.STRUCT.MOL.BIOL. V. 19 906 2012REFN ISSN 1545-9993PMID 22902367DOI 10.1038/NSMB.2366 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4n4w SMO structure of the human smoothened receptor in complex with sant-1. 2.8Å AUTH C.WANG,H.WU,T.EVRON,E.VARDY,G.W.HAN,X.P.HUANG,S.J.HUFEISEN,AUTH 2 T.J.MANGANO,D.J.URBAN,V.KATRITCH,V.CHEREZOV,M.G.CARON,AUTH 3 B.L.ROTH,R.C.STEVENSTITL STRUCTURAL BASIS FOR SMOOTHENED RECEPTOR MODULATION ANDTITL 2 CHEMORESISTANCE TO ANTICANCER DRUGS.REF NAT COMMUN V. 5 4355 2014REFN ESSN 2041-1723PMID 25008467DOI 10.1038/NCOMMS5355 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 1kcg ULBP3 nkg2d in complex with ulbp3 2.6Å AUTH S.RADAEV,B.ROSTRO,A.G.BROOKS,M.COLONNA,P.D.SUNTITL CONFORMATIONAL PLASTICITY REVEALED BY THETITL 2 COCRYSTAL STRUCTURE OF NKG2D AND ITS CLASS ITITL 3 MHC-LIKE LIGAND ULBP3.REF IMMUNITY V. 15 1039 2001REFN ISSN 1074-7613PMID 11754823DOI 10.1016/S1074-7613(01)00241-2 Variant Set Distributions Mapped Variants
General Structure Information 3b2d CD180 crystal structure of human rp105/md-1 complex 2.8Å AUTH U.OHTO,K.MIYAKE,T.SHIMIZUTITL CRYSTAL STRUCTURES OF MOUSE AND HUMAN RP105/MD-1 COMPLEXESTITL 2 REVEAL UNIQUE DIMER ORGANIZATION OF THE TOLL-LIKE RECEPTORTITL 3 FAMILY.REF J.MOL.BIOL. V. 413 815 2011REFN ISSN 0022-2836PMID 21959264DOI 10.1016/J.JMB.2011.09.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants