Assessment of Structural Intolerance and Durability
General Structure Information 4mxw LTBR structure of heterotrimeric lymphotoxin lta1b2 bound to lymphotoxin beta receptor ltbr and anti-lta fab 3.6Å AUTH J.SUDHAMSU,J.YIN,E.Y.CHIANG,M.A.STAROVASNIK,J.L.GROGAN,AUTH 2 S.G.HYMOWITZTITL DIMERIZATION OF LT BETA R BY LT ALPHA 1 BETA 2 IS NECESSARYTITL 2 AND SUFFICIENT FOR SIGNAL TRANSDUCTION.REF PROC.NATL.ACAD.SCI.USA V. 110 19896 2013REFN ISSN 0027-8424PMID 24248355DOI 10.1073/PNAS.1310838110 Variant Set Distributions […]
General Structure Information 2lly CHRNA4 nmr structures of the transmembrane domains of the nachr a4 subunit -1.0Å AUTH V.BONDARENKO,D.MOWREY,T.TILLMAN,T.CUI,L.T.LIU,Y.XU,P.TANGTITL NMR STRUCTURES OF THE TRANSMEMBRANE DOMAINS OF THE A4B2TITL 2 NACHR.REF BIOCHIM.BIOPHYS.ACTA V.1818 1261 2012REFN ISSN 0006-3002PMID 22361591DOI 10.1016/J.BBAMEM.2012.02.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2v5e GDNF the structure of the gdnf:coreceptor complex: insights into ret signalling and heparin binding. 2.35Å AUTH V.PARKASH,V.-M.LEPPANEN,H.VIRTANEN,J.-M.JURVANSUU,AUTH 2 M.M.BESPALOV,Y.A.SIDOROVA,P.RUNEBERG-ROOS,M.SAARMA,AUTH 3 A.GOLDMANTITL THE STRUCTURE OF THE GLIAL CELL LINE-DERIVEDTITL 2 NEUROTROPHIC FACTOR-CORECEPTOR COMPLEX: INSIGHTSTITL 3 INTO RET SIGNALING AND HEPARIN BINDING.REF J.BIOL.CHEM. V. 283 35164 2008REFN ISSN 0021-9258PMID 18845535DOI 10.1074/JBC.M802543200 Variant Set […]
General Structure Information 3tje FAS crystal structure of fas receptor extracellular domain in complex with fab e09 1.93Å AUTH M.CHODORGE,S.ZUGER,C.STIRNIMANN,C.BRIAND,L.JERMUTUS,AUTH 2 M.G.GRUTTER,R.R.MINTERTITL A SERIES OF FAS RECEPTOR AGONIST ANTIBODIES THAT DEMONSTRATETITL 2 AN INVERSE CORRELATION BETWEEN AFFINITY AND POTENCY.REF CELL DEATH DIFFER. V. 19 1187 2012REFN ISSN 1350-9047PMID 22261618DOI 10.1038/CDD.2011.208 Variant Set Distributions Mapped Variants
General Structure Information 1rpm PTPRM human receptor protein tyrosine phosphatase mu, domain 1 2.3Å AUTH K.M.HOFFMANN,N.K.TONKS,D.BARFORDTITL THE CRYSTAL STRUCTURE OF DOMAIN 1 OF RECEPTORTITL 2 PROTEIN-TYROSINE PHOSPHATASE MU.REF J.BIOL.CHEM. V. 272 27505 1997REFN ISSN 0021-9258PMID 9346878DOI 10.1074/JBC.272.44.27505 Variant Set Distributions Mapped Variants
General Structure Information 3k72 ITGAX structure of integrin alphax beta2 3.7Å AUTH C.XIE,J.ZHU,X.CHEN,L.MI,N.NISHIDA,T.A.SPRINGERTITL STRUCTURE OF AN INTEGRIN WITH AN ALPHAI DOMAIN,TITL 2 COMPLEMENT RECEPTOR TYPE 4.REF EMBO J. V. 29 666 2010REFN ISSN 0261-4189PMID 20033057DOI 10.1038/EMBOJ.2009.367 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3kex ERBB3 crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (her3) 2.8Å AUTH N.JURA,Y.SHAN,X.CAO,D.E.SHAW,J.KURIYANTITL STRUCTURAL ANALYSIS OF THE CATALYTICALLY INACTIVETITL 2 KINASE DOMAIN OF THE HUMAN EGF RECEPTOR 3.REF PROC.NATL.ACAD.SCI.USA V. 106 21608 2009REFN ISSN 0027-8424PMID 20007378DOI 10.1073/PNAS.0912101106 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1iil FGFR2 crystal structure of pro253arg apert mutant fgf receptor 2 (fgfr2) in complex with fgf2 2.3Å AUTH O.A.IBRAHIMI,A.V.ELISEENKOVA,A.N.PLOTNIKOV,K.YU,AUTH 2 D.M.ORNITZ,M.MOHAMMADITITL STRUCTURAL BASIS FOR FIBROBLAST GROWTH FACTORTITL 2 RECEPTOR 2 ACTIVATION IN APERT SYNDROME.REF PROC.NATL.ACAD.SCI.USA V. 98 7182 2001REFN ISSN 0027-8424PMID 11390973DOI 10.1073/PNAS.121183798 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3cjw NR2F2 crystal structure of the human coup-tfii ligand binding domain 1.48Å AUTH S.W.KRUSE,K.SUINO-POWELL,X.E.ZHOU,J.E.KRETSCHMAN,AUTH 2 R.REYNOLDS,C.VONRHEIN,Y.XU,L.WANG,S.Y.TSAI,AUTH 3 M.J.TSAI,H.E.XUTITL IDENTIFICATION OF COUP-TFII ORPHAN NUCLEARTITL 2 RECEPTOR AS A RETINOIC ACID-ACTIVATED RECEPTOR.REF PLOS BIOL. V. 6 E227 2008REFN ISSN 1544-9173PMID 18798693DOI 10.1371/JOURNAL.PBIO.0060227 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2c0l SCP2 tpr domain of human pex5p in complex with human mscp2 2.3Å AUTH W.A.STANLEY,F.V.FILIPP,P.KURSULA,N.SCHULLER,AUTH 2 R.ERDMANN,W.SCHLIEBS,M.SATTLER,M.WILMANNSTITL RECOGNITION OF A FUNCTIONAL PEROXISOME TYPE 1TITL 2 TARGET BY THE DYNAMIC IMPORT RECEPTOR PEX5P.REF MOL.CELL V. 24 653 2006REFN ISSN 1097-2765PMID 17157249DOI 10.1016/J.MOLCEL.2006.10.024 Variant Set Distributions Mapped Variants