Assessment of Structural Intolerance and Durability
General Structure Information 3e0g LIFR structure of the leukemia inhibitory factor receptor (lif-r) domains d1-d5 3.1Å AUTH G.SKINIOTIS,P.J.LUPARDUS,M.MARTICK,T.WALZ,K.C.GARCIATITL STRUCTURAL ORGANIZATION OF A FULL-LENGTH GP130/LIF-RTITL 2 CYTOKINE RECEPTOR TRANSMEMBRANE COMPLEX.REF MOL.CELL V. 31 737 2008REFN ISSN 1097-2765PMID 18775332DOI 10.1016/J.MOLCEL.2008.08.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pbl DRD3 structure of the human dopamine d3 receptor in complex with eticlopride 2.89Å AUTH E.Y.CHIEN,W.LIU,Q.ZHAO,V.KATRITCH,G.W.HAN,M.A.HANSON,L.SHI,AUTH 2 A.H.NEWMAN,J.A.JAVITCH,V.CHEREZOV,R.C.STEVENSTITL STRUCTURE OF THE HUMAN DOPAMINE D3 RECEPTOR IN COMPLEX WITHTITL 2 A D2/D3 SELECTIVE ANTAGONIST.REF SCIENCE V. 330 1091 2010REFN ISSN 0036-8075PMID 21097933DOI 10.1126/SCIENCE.1197410 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4n6h OPRD1 1.8 a structure of the human delta opioid 7tm receptor (psi community target) 1.8Å AUTH G.FENALTI,P.M.GIGUERE,V.KATRITCH,X.P.HUANG,A.A.THOMPSON,AUTH 2 V.CHEREZOV,B.L.ROTH,R.C.STEVENSTITL MOLECULAR CONTROL OF DELTA-OPIOID RECEPTOR SIGNALLING.REF NATURE V. 506 191 2014REFN ISSN 0028-0836PMID 24413399DOI 10.1038/NATURE12944 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2fcb FCGR2B human fc gamma receptor iib ectodomain (cd32) 1.74Å AUTH P.SONDERMANN,R.HUBER,U.JACOBTITL CRYSTAL STRUCTURE OF THE SOLUBLE FORM OF THE HUMANTITL 2 FCGAMMA-RECEPTOR IIB: A NEW MEMBER OF THETITL 3 IMMUNOGLOBULIN SUPERFAMILY AT 1.7 A RESOLUTION.REF EMBO J. V. 18 1095 1999REFN ISSN 0261-4189PMID 10064577DOI 10.1093/EMBOJ/18.5.1095 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1plo TGFBR2 transforming growth factor-beta type ii receptor extracellular domain -1.0Å AUTH S.DEEP,K.P.WALKER III,Z.SHU,A.P.HINCKTITL SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF THETITL 2 TGF-BETA TYPE II RECEPTOR EXTRACELLULAR DOMAINREF BIOCHEMISTRY V. 42 10126 2003REFN ISSN 0006-2960PMID 12939140DOI 10.1021/BI034366A Variant Set Distributions Mapped Variants
General Structure Information 1n83 RORA crystal structure of the complex between the orphan nuclear hormone receptor ror(alpha)-lbd and cholesterol 1.63Å AUTH J.A.KALLEN,J.M.SCHLAEPPI,F.BITSCH,S.GEISSE,AUTH 2 M.GEISER,I.DELHON,B.FOURNIERTITL X-RAY STRUCTURE OF HROR(ALPHA) LBD AT 1.63A:TITL 2 STRUCTURAL AND FUNCTIONAL DATA THAT CHOLESTEROL ORTITL 3 A CHOLESTEROL DERIVATIVE IS THE NATURAL LIGAND OFTITL 4 ROR(ALPHA)REF STRUCTURE V. 10 1697 2002REFN […]
General Structure Information 3be2 KDR crystal structure of the vegfr2 kinase domain in complex with a benzamide inhibitor 1.75Å AUTH J.C.HARMANGE,M.M.WEISS,J.GERMAIN,A.J.POLVERINO,AUTH 2 G.BORG,J.BREADY,D.CHEN,D.CHOQUETTE,A.COXON,AUTH 3 T.DEMELFI,L.DIPIETRO,N.DOERR,J.ESTRADA,J.FLYNN,AUTH 4 R.F.GRACEFFA,S.P.HARRIMAN,S.KAUFMAN,D.S.LA,A.LONG,AUTH 5 M.W.MARTIN,S.NEERVANNAN,V.F.PATEL,M.POTASHMAN,AUTH 6 K.REGAL,P.M.ROVETO,M.L.SCHRAG,C.STARNES,A.TASKER,AUTH 7 Y.TEFFERA,L.WANG,R.D.WHITE,D.A.WHITTINGTON,R.ZANONTITL NAPHTHAMIDES AS NOVEL AND POTENT VASCULARTITL 2 ENDOTHELIAL GROWTH FACTOR RECEPTOR TYROSINE KINASETITL 3 INHIBITORS: DESIGN, SYNTHESIS, AND EVALUATION.REF J.MED.CHEM. V. 51 […]
General Structure Information 4ea3 OPRL1 structure of the n/ofq opioid receptor in complex with a peptide mimetic 3.01Å AUTH A.A.THOMPSON,W.LIU,E.CHUN,V.KATRITCH,H.WU,E.VARDY,X.P.HUANG,AUTH 2 C.TRAPELLA,R.GUERRINI,G.CALO,B.L.ROTH,V.CHEREZOV,R.C.STEVENSTITL STRUCTURE OF THE NOCICEPTIN/ORPHANIN FQ RECEPTOR IN COMPLEXTITL 2 WITH A PEPTIDE MIMETIC.REF NATURE V. 485 395 2012REFN ISSN 0028-0836PMID 22596163DOI 10.1038/NATURE11085 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2wjx GRIA2 crystal structure of the human ionotropic glutamate receptor glur2 atd region at 4.1 a resolution 4.1Å AUTH A.CLAYTON,C.SIEBOLD,R.J.C.GILBERT,G.C.SUTTON,AUTH 2 K.HARLOS,R.A.J.MCILHINNEY,E.Y.JONES,A.R.ARICESCUTITL CRYSTAL STRUCTURE OF THE GLUR2 AMINO-TERMINALTITL 2 DOMAIN PROVIDES INSIGHTS INTO THE ARCHITECTURE ANDTITL 3 ASSEMBLY OF IONOTROPIC GLUTAMATE RECEPTORS.REF J.MOL.BIOL. V. 392 1125 2009REFN ISSN 0022-2836PMID 19651138DOI 10.1016/J.JMB.2009.07.082 Variant […]
General Structure Information 2z3r IL15 crystal structure of the il-15/il-15ra complex 2.0Å AUTH M.CHIRIFU,C.HAYASHI,T.NAKAMURA,S.TOMA,T.SHUTO,H.KAI,AUTH 2 Y.YAMAGATA,S.J.DAVIS,S.IKEMIZUTITL CRYSTAL STRUCTURE OF THE IL-15-IL-15RALPHA COMPLEX, ATITL 2 CYTOKINE-RECEPTOR UNIT PRESENTED IN TRANSREF NAT.IMMUNOL. V. 8 1001 2007REFN ISSN 1529-2908PMID 17643103DOI 10.1038/NI1492 Variant Set Distributions Mapped Variants