Assessment of Structural Intolerance and Durability
General Structure Information 1kzz TRAF3 downstream regulator tank binds to the cd40 recognition site on traf3 3.5Å AUTH C.LI,C.Z.NI,M.L.HAVERT,E.CABEZAS,J.HE,D.KAISER,AUTH 2 J.C.REED,A.C.SATTERTHWAIT,G.CHENG,K.R.ELYTITL DOWNSTREAM REGULATOR TANK BINDS TO THE CD40TITL 2 RECOGNITION SITE ON TRAF3.REF STRUCTURE V. 10 403 2002REFN ISSN 0969-2126PMID 12005438DOI 10.1016/S0969-2126(02)00733-5 Variant Set Distributions Mapped Variants
General Structure Information 4k0v TEK structural basis for angiopoietin-1 mediated signaling initiation 4.51Å AUTH X.YU,T.C.SEEGAR,A.C.DALTON,D.TZVETKOVA-ROBEV,Y.GOLDGUR,AUTH 2 K.R.RAJASHANKAR,D.B.NIKOLOV,W.A.BARTONTITL STRUCTURAL BASIS FOR ANGIOPOIETIN-1-MEDIATED SIGNALINGTITL 2 INITIATION.REF PROC.NATL.ACAD.SCI.USA V. 110 7205 2013REFN ISSN 0027-8424PMID 23592718DOI 10.1073/PNAS.1216890110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dbj MERTK solution structures of the fn3 domain of human proto- oncogene tyrosine-protein kinase mer precursor -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE FN3 DOMAIN OF HUMANTITL 2 PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MERTITL 3 PRECURSORREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2jjs CD47 structure of human cd47 in complex with human signal regulatory protein (sirp) alpha 1.85Å AUTH D.HATHERLEY,S.C.GRAHAM,J.TURNER,K.HARLOS,AUTH 2 D.I.STUART,A.N.BARCLAYTITL PAIRED RECEPTOR SPECIFICITY EXPLAINED BYTITL 2 STRUCTURES OF SIGNAL REGULATORY PROTEINS ALONE ANDTITL 3 COMPLEXED WITH CD47.REF MOL.CELL V. 31 266 2008REFN ISSN 1097-2765PMID 18657508DOI 10.1016/J.MOLCEL.2008.05.026 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4n0f FCGRT human fcrn complexed with human serum albumin 3.02Å AUTH V.OGANESYAN,M.M.DAMSCHRODER,K.E.COOK,Q.LI,C.GAO,H.WU,AUTH 2 W.F.DALLACQUATITL STRUCTURAL INSIGHTS INTO NEONATAL FC RECEPTOR-BASEDTITL 2 RECYCLING MECHANISMS.REF J.BIOL.CHEM. V. 289 7812 2014REFN ISSN 0021-9258PMID 24469444DOI 10.1074/JBC.M113.537563 Variant Set Distributions Mapped Variants
General Structure Information 3oe8 CXCR4 crystal structure of the cxcr4 chemokine receptor in complex with a small molecule antagonist it1t in p1 spacegroup 3.1Å AUTH B.WU,E.Y.CHIEN,C.D.MOL,G.FENALTI,W.LIU,V.KATRITCH,R.ABAGYAN,AUTH 2 A.BROOUN,P.WELLS,F.C.BI,D.J.HAMEL,P.KUHN,T.M.HANDEL,AUTH 3 V.CHEREZOV,R.C.STEVENSTITL STRUCTURES OF THE CXCR4 CHEMOKINE GPCR WITH SMALL-MOLECULETITL 2 AND CYCLIC PEPTIDE ANTAGONISTS.REF SCIENCE V. 330 1066 2010REFN ISSN 0036-8075PMID 20929726DOI 10.1126/SCIENCE.1194396 Variant Set Distributions […]
General Structure Information 2m0p LRP2 solution structure of the tenth complement type repeat of human megalin -1.0Å AUTH R.DAGIL,C.OSHEA,A.NYKJAR,A.M.BONVIN,B.B.KRAGELUNDTITL GENTAMICIN BINDS TO THE MEGALIN RECEPTOR AS A COMPETITIVETITL 2 INHIBITOR USING THE COMMON LIGAND BINDING MOTIF OFTITL 3 COMPLEMENT TYPE REPEATS: INSIGHT FROM THE NMR STRUCTURE OFTITL 4 THE 10TH COMPLEMENT TYPE REPEAT DOMAIN ALONE […]
General Structure Information 2npl CXADR nmr structure of card d2 domain -1.0Å AUTH S.JIANG,M.CAFFREYTITL SOLUTION STRUCTURE OF THE COXSACKIEVIRUS ANDTITL 2 ADENOVIRUS RECEPTOR DOMAIN 2REF PROTEIN SCI. V. 16 539 2007REFN ISSN 0961-8368PMID 17322536DOI 10.1110/PS.062643507 Variant Set Distributions Mapped Variants
General Structure Information 4my2 NDP crystal structure of norrin in fusion with maltose binding protein 2.4Å AUTH J.KE,K.G.HARIKUMAR,C.ERICE,C.CHEN,X.GU,L.WANG,N.PARKER,AUTH 2 Z.CHENG,W.XU,B.O.WILLIAMS,K.MELCHER,L.J.MILLER,H.E.XUTITL STRUCTURE AND FUNCTION OF NORRIN IN ASSEMBLY AND ACTIVATIONTITL 2 OF A FRIZZLED 4-LRP5/6 COMPLEX.REF GENES DEV. V. 27 2305 2013REFN ISSN 0890-9369PMID 24186977DOI 10.1101/GAD.228544.113 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4aow GNB2L1 crystal structure of the human rack1 protein at a resolution of 2.45 angstrom 2.45Å AUTH D.RUIZ CARRILLO,R.CHANDRASEKARAN,M.NILSSON,T.CORNVIK,AUTH 2 C.W.LIEW,S.M.TAN,J.LESCARTITL STRUCTURE OF HUMAN RACK1 PROTEIN AT A RESOLUTION OF 2.45 A.REF ACTA CRYSTALLOGR.,SECT.F V. 68 867 2012REFN ISSN 1744-3091PMID 22869111DOI 10.1107/S1744309112027480 Variant Set Distributions Mapped Variants