2DBJ.A | MERTK

General Structure Information

PDB ID	2dbj
HGNC Gene Label(s)	MERTK
Structure Name	solution structures of the fn3 domain of human proto- oncogene tyrosine-protein kinase mer precursor
Resolution	-1.0Å
Reference	AUTH M.SATO,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE FN3 DOMAIN OF HUMANTITL 2 PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MERTITL 3 PRECURSORREF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	111
Number Of SNVs	39
Number Of Permutations	19999
Optimal Distance Threshold	12.0
K Statistic	0.221
p-value	0.949

COSMIC

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	39
Number Of COSMIC SNVs	3
Optimal Distance Threshold	24.0
K Statistic	-0.321
p-value	0.782

Pathogenic Proximity Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:112733036		S>R	A:12	(-24.11, -0.53, 8.34)
2:112733038	COSM1325991	T>M	A:13	(-20.82, 1.89, 10.03)
2:112733045		E>D	A:15	(-19.96, 8.32, 11.53)
2:112733047		G>V	A:16	(-16.00, 6.74, 11.10)
2:112740424		S>P	A:19	(-9.84, 11.24, 7.43)
2:112740434		P>L	A:22	(0.52, 6.76, 5.97)
2:112740439		N>Y	A:24	(7.86, 9.43, 7.82)
2:112740458		N>S	A:30	(16.77, -3.01, -3.41)
2:112740478		D>H	A:37	(12.24, -1.41, 1.32)
2:112740481	rs143584038	I>L	A:38	(7.26, -0.60, 1.58)
2:112740490	rs377752022	M>V	A:41	(5.96, 7.35, 11.08)
2:112740496		P>A	A:43	(-1.43, 7.58, 11.51)
2:112740497	rs147166671	P>L	A:43	(-1.43, 7.58, 11.51)
2:112740500		P>L	A:44	(-2.06, 11.74, 13.69)
2:112740503	rs3761698	T>I	A:45	(-5.25, 8.26, 13.65)
2:112740507		K>N	A:46	(-4.48, 10.92, 19.76)
2:112740515	rs370278504	D>V	A:49	(-11.11, 8.76, 15.25)
2:112740521		E>V	A:51	(-7.47, 1.73, 17.43)
2:112740532		Y>H	A:55	(-0.87, 0.53, 8.27)
2:112740535	rs142985827	R>W	A:56	(-5.97, -0.70, 2.02)
2:112740536	rs138908058	R>Q	A:56	(-5.97, -0.70, 2.02)
2:112740538	rs573038792	I>L	A:57	(0.76, -1.34, 1.02)
2:112740547	COSM3425104	V>M	A:60	(-0.70, -0.67, -9.90)
2:112740556	rs555016686 COSM98937	S>G	A:63	(4.39, -1.77, -18.82)
2:112740560	rs374989199	A>V	A:64	(4.76, -0.61, -22.67)
2:112751834		L>I	A:70	(-0.17, -6.63, -7.60)
2:112751840		E>Q	A:72	(0.29, -5.87, 0.42)
2:112751846		V>F	A:74	(0.27, -4.61, 5.70)
2:112751847		V>A	A:74	(0.27, -4.61, 5.70)
2:112751865	rs202242962 COSM168800 COSM1527755	R>Q	A:80	(9.03, -4.40, 8.24)
2:112751870	rs370577205	R>W	A:82	(10.52, -7.68, 1.43)
2:112751871		R>Q	A:82	(10.52, -7.68, 1.43)
2:112751898		T>M	A:91	(6.27, 3.29, -14.58)
2:112751903		T>A	A:93	(2.11, 4.23, -8.49)
2:112751904	rs556417937	T>I	A:93	(2.11, 4.23, -8.49)
2:112751919		A>G	A:98	(-4.52, 4.30, 7.52)
2:112751921	rs148833587	V>I	A:99	(-6.83, 0.01, 7.81)
2:112751927		R>G	A:101	(-12.62, -2.72, 15.17)
2:112751928	rs7604639	R>K	A:101	(-12.62, -2.72, 15.17)
2:112751930	COSM4084197	G>W	A:102	(-13.96, 1.23, 10.71)
2:112751957		V>L	A:111	(5.82, 6.93, -4.76)
2:112751967	rs145142422	F>Y	A:114	(12.99, 3.28, -13.47)
2:112751971	COSM3565287	I>M	A:115	(10.77, -1.17, -11.77)
2:112751972		P>S	A:116	(15.52, -1.02, -12.89)
2:112751975	rs374488598	A>T	A:117	(15.62, -3.72, -16.98)

2DBJ.A | MERTK.

2DBJ.A | MERTK

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Pathogenic Proximity Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:112740565	COSM48561	I>F	A:66	(2.11, -5.91, -19.96)
2:112751892	COSM131257	N>S	A:89	(11.61, -1.88, -18.30)
2:112751928	COSM4418611	R>K	A:101	(-12.62, -2.72, 15.17)