Assessment of Structural Intolerance and Durability
General Structure Information 3mqp BCL2A1 crystal structure of human bfl-1 in complex with noxa bh3 peptide, northeast structural genomics consortium target hr2930 2.24Å AUTH R.GUAN,R.XIAO,L.ZHAO,T.B.ACTON,C.GELINAS,G.T.MONTELIONETITL CRYSTAL STRUCTURE OF HUMAN BFL-1 IN COMPLEX WITH NOXA BH3TITL 2 PEPTIDEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2oq0 IFI16 crystal structure of the first hin-200 domain of interferon-inducible protein 16 2.0Å AUTH J.C.C.LIAO,R.LAM,M.RAVICHANDRAN,J.MA,W.TEMPEL,N.Y.CHIRGADZE,AUTH 2 C.H.ARROWSMITHTITL CRYSTAL STRUCTURE OF THE FIRST HIN-200 DOMAIN OFTITL 2 INTERFERON-INDUCIBLE PROTEIN 16REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2kz5 NFE2 solution nmr structure of transcription factor nf-e2 subunits dna binding domain from homo sapiens, northeast structural genomics consortium target hr4653b -1.0Å AUTH G.LIU,H.JANJUA,R.XIAO,C.CICCOSANTI,R.SHASTRY,T.B.ACTON,AUTH 2 S.TONG,J.K.EVERETT,G.T.MONTELIONETITL NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR4653BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3b6y IFI16 crystal structure of the second hin-200 domain of interferon-inducible protein 16 2.35Å AUTH J.C.C.LIAO,R.LAM,M.RAVICHANDRAN,S.DUAN,W.TEMPEL,AUTH 2 N.Y.CHIRGADZE,C.H.ARROWSMITHTITL CRYSTAL STRUCTURE ANALYSIS OF THE SECOND HIN DOMAIN OFTITL 2 IFI16.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2khn ITSN1 nmr solution structure of the eh 1 domain from human intersectin-1 protein. northeast structural genomics consortium target hr3646e. -1.0Å AUTH J.L.MILLS,A.GHOSH,E.GARCIA,Q.ZHANG,R.SHASTRY,AUTH 2 E.L.FOOTE,H.JANJUA,T.B.ACTON,R.XIAO,J.K.EVERETT,AUTH 3 G.T.MONTELIONE,T.SZYPERSKITITL NMR SOLUTION STRUCTURE OF THE EH 1 DOMAIN FROMTITL 2 HUMAN INTERSECTIN-1 PROTEIN. NORTHEAST STRUCTURALTITL 3 GENOMICS CONSORTIUM TARGET HR3646E.REF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 2jng CUL7 solution structure of the cul7-cph domain from homo sapiens; northeast structural genomics consortium target ht1. -1.0Å AUTH L.KAUSTOV,J.LUKIN,A.LEMAK,S.DUAN,M.HO,R.DOHERTY,AUTH 2 L.Z.PENN,C.H.ARROWSMITHTITL THE CONSERVED CPH DOMAINS OF CUL7 AND PARC ARETITL 2 PROTEIN-PROTEIN INTERACTION MODULES THAT BIND THETITL 3 TETRAMERIZATION DOMAIN OF P53REF J.BIOL.CHEM. V. 282 11300 2007REFN ISSN 0021-9258PMID 17298945DOI 10.1074/JBC.M611297200 […]
General Structure Information 3fb2 SPTAN1 crystal structure of the human brain alpha spectrin repeats 15 and 16. northeast structural genomics consortium target hr5563a. 2.3Å AUTH S.M.VOROBIEV,M.SU,J.SEETHARAMAN,R.SHASTRY,AUTH 2 E.L.FOOTE,C.CICCOSANTI,H.JANJUA,R.XIAO,T.B.ACTON,AUTH 3 G.T.MONTELIONE,L.TONG,J.F.HUNTTITL CRYSTAL STRUCTURE OF THE HUMAN BRAIN ALPHATITL 2 SPECTRIN REPEATS 15 AND 16.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2kr1 UBE3A solution nmr structure of zinc binding n-terminal domain of ubiquitin- protein ligase e3a from homo sapiens. northeast structural genomics consortium (nesg) target hr3662 -1.0Å AUTH A.LEMAK,A.YEE,I.BEZSONOVA,S.DHE-PAGANON,C.H.ARROWSMITHTITL ZN-BINDING AZUL DOMAIN OF HUMAN UBIQUITIN PROTEIN LIGASETITL 2 UBE3A.REF J.BIOMOL.NMR V. 51 185 2011REFN ISSN 0925-2738PMID 21947926DOI 10.1007/S10858-011-9552-Y Variant Set Distributions Ripley’s K […]
General Structure Information 3oe8 CXCR4 crystal structure of the cxcr4 chemokine receptor in complex with a small molecule antagonist it1t in p1 spacegroup 3.1Å AUTH B.WU,E.Y.CHIEN,C.D.MOL,G.FENALTI,W.LIU,V.KATRITCH,R.ABAGYAN,AUTH 2 A.BROOUN,P.WELLS,F.C.BI,D.J.HAMEL,P.KUHN,T.M.HANDEL,AUTH 3 V.CHEREZOV,R.C.STEVENSTITL STRUCTURES OF THE CXCR4 CHEMOKINE GPCR WITH SMALL-MOLECULETITL 2 AND CYCLIC PEPTIDE ANTAGONISTS.REF SCIENCE V. 330 1066 2010REFN ISSN 0036-8075PMID 20929726DOI 10.1126/SCIENCE.1194396 Variant Set Distributions […]
General Structure Information 3oe8 CXCR4 crystal structure of the cxcr4 chemokine receptor in complex with a small molecule antagonist it1t in p1 spacegroup 3.1Å AUTH B.WU,E.Y.CHIEN,C.D.MOL,G.FENALTI,W.LIU,V.KATRITCH,R.ABAGYAN,AUTH 2 A.BROOUN,P.WELLS,F.C.BI,D.J.HAMEL,P.KUHN,T.M.HANDEL,AUTH 3 V.CHEREZOV,R.C.STEVENSTITL STRUCTURES OF THE CXCR4 CHEMOKINE GPCR WITH SMALL-MOLECULETITL 2 AND CYCLIC PEPTIDE ANTAGONISTS.REF SCIENCE V. 330 1066 2010REFN ISSN 0036-8075PMID 20929726DOI 10.1126/SCIENCE.1194396 Variant Set Distributions […]