Assessment of Structural Intolerance and Durability
General Structure Information 3n1q CDON crystal structure of dhhn bound to cdofn3 2.89Å AUTH J.M.KAVRAN,M.D.WARD,O.O.OLADOSU,S.MULEPATI,D.J.LEAHYTITL ALL MAMMALIAN HEDGEHOG PROTEINS INTERACT WITH CDO AND BOCTITL 2 IN A CONSERVED MANNER.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20519495DOI 10.1074/JBC.M110.131680 Variant Set Distributions Mapped Variants
General Structure Information 4flb RPRD2 cid of human rprd2 1.8Å AUTH Z.NI,C.XU,X.GUO,G.O.HUNTER,O.V.KUZNETSOVA,W.TEMPEL,E.MARCON,AUTH 2 G.ZHONG,H.GUO,W.H.KUO,J.LI,P.YOUNG,J.B.OLSEN,C.WAN,AUTH 3 P.LOPPNAU,M.EL BAKKOURI,G.A.SENISTERRA,H.HE,H.HUANG,AUTH 4 S.S.SIDHU,A.EMILI,S.MURPHY,A.L.MOSLEY,C.H.ARROWSMITH,J.MIN,AUTH 5 J.F.GREENBLATTTITL RPRD1A AND RPRD1B ARE HUMAN RNA POLYMERASE II C-TERMINALTITL 2 DOMAIN SCAFFOLDS FOR SER5 DEPHOSPHORYLATION.REF NAT.STRUCT.MOL.BIOL. V. 21 686 2014REFN ISSN 1545-9993PMID 24997600DOI 10.1038/NSMB.2853 Variant Set Distributions Mapped Variants
General Structure Information 2ld4 CIAPIN1 solution structure of the n-terminal domain of human anamorsin -1.0Å AUTH L.BANCI,I.BERTINI,S.CIOFI-BAFFONI,F.BOSCARO,A.CHATZI,AUTH 2 M.MIKOLAJCZYK,K.TOKATLIDIS,J.WINKELMANNTITL ANAMORSIN IS A [2FE-2S] CLUSTER-CONTAINING SUBSTRATE OF THETITL 2 MIA40-DEPENDENT MITOCHONDRIAL PROTEIN TRAPPING MACHINERY.REF CHEM.BIOL. V. 18 794 2011REFN ISSN 1074-5521PMID 21700214DOI 10.1016/J.CHEMBIOL.2011.03.015 Variant Set Distributions Mapped Variants
General Structure Information 2cqk LARP4 solution structure of the la domain of c-mpl binding protein -1.0Å AUTH S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE LA DOMAIN OF C-MPLTITL 2 BINDING PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4doh IL20RB il20/il201/il20r2 ternary complex 2.8Å AUTH N.J.LOGSDON,A.DESHPANDE,B.D.HARRIS,K.R.RAJASHANKAR,AUTH 2 M.R.WALTERTITL STRUCTURAL BASIS FOR RECEPTOR SHARING AND ACTIVATION BYTITL 2 INTERLEUKIN-20 RECEPTOR-2 (IL-20R2) BINDING CYTOKINES.REF PROC.NATL.ACAD.SCI.USA V. 109 12704 2012REFN ISSN 0027-8424PMID 22802649DOI 10.1073/PNAS.1117551109 Variant Set Distributions Mapped Variants
General Structure Information 1u2h SPEG x-ray structure of the n-terminally truncated human apep-1 0.96Å AUTH B.A.MANJASETTY,F.H.NIESEN,C.SCHEICH,Y.ROSKE,F.GOTZ,AUTH 2 J.BEHLKE,V.SIEVERT,U.HEINEMANN,K.BUSSOWTITL X-RAY STRUCTURE OF ENGINEERED HUMAN AORTICTITL 2 PREFERENTIALLY EXPRESSED PROTEIN-1 (APEG-1)REF BMC STRUCT.BIOL. V. 5 21 2005REFN ESSN 1472-6807PMID 16354304DOI 10.1186/1472-6807-5-21 Variant Set Distributions Mapped Variants
General Structure Information 2hq6 CWC27 structure of the cyclophilin_cecyp16-like domain of the serologically defined colon cancer antigen 10 from homo sapiens 1.75Å AUTH J.R.WALKER,T.DAVIS,R.PARAMANATHAN,E.M.NEWMAN,AUTH 2 P.J.FINERTY JR.,F.MACKENZIE,J.WEIGELT,M.SUNDSTROM,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURE OF THE CYCLOPHILIN_CECYP16-LIKE DOMAIN OF THETITL 2 SEROLOGICALLY DEFINED COLON CANCER ANTIGEN 10REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3v2b PARP15 human poly(adp-ribose) polymerase 15 (artd7, bal3), macro domain 2 in complex with adenosine-5-diphosphoribose 2.2Å AUTH A.H.FORST,T.KARLBERG,N.HERZOG,A.G.THORSELL,A.GROSS,AUTH 2 K.L.FEIJS,P.VERHEUGD,P.KURSULA,B.NIJMEIJER,E.KREMMER,AUTH 3 H.KLEINE,A.G.LADURNER,H.SCHULER,B.LUSCHERTITL RECOGNITION OF MONO-ADP-RIBOSYLATED ARTD10 SUBSTRATES BYTITL 2 ARTD8 MACRODOMAINS.REF STRUCTURE V. 21 462 2013REFN ISSN 0969-2126PMID 23473667DOI 10.1016/J.STR.2012.12.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4n5x SLC25A24 crystal structure of n-terminal calmodulin-like calcium sensor of human mitochondrial atp-mg/pi carrier scamc1 2.1Å AUTH Q.YANG,S.BRUSCHWEILER,J.J.CHOUTITL A SELF-SEQUESTERED CALMODULIN-LIKE CA(2+) SENSOR OFTITL 2 MITOCHONDRIAL SCAMC CARRIER AND ITS IMPLICATION TOTITL 3 CA(2+)-DEPENDENT ATP-MG/PI TRANSPORT.REF STRUCTURE V. 22 209 2014REFN ISSN 0969-2126PMID 24332718DOI 10.1016/J.STR.2013.10.018 Variant Set Distributions Mapped Variants
General Structure Information 3swy CNGA3 cnga3 626-672 containing clz domain 1.9Å AUTH N.G.SHUART,Y.HAITIN,S.S.CAMP,K.D.BLACK,W.N.ZAGOTTATITL MOLECULAR MECHANISM FOR 3:1 SUBUNIT STOICHIOMETRY OF RODTITL 2 CYCLIC NUCLEOTIDE-GATED ION CHANNELS.REF NAT COMMUN V. 2 457 2011REFN ESSN 2041-1723PMID 21878911DOI 10.1038/NCOMMS1466 Variant Set Distributions Mapped Variants