Assessment of Structural Intolerance and Durability
General Structure Information 1d1j PFN2 crystal structure of human profilin ii 2.2Å AUTH I.M.NODELMAN,G.D.BOWMAN,U.LINDBERG,C.E.SCHUTTTITL X-RAY STRUCTURE DETERMINATION OF HUMAN PROFILINTITL 2 II: A COMPARATIVE STRUCTURAL ANALYSIS OF HUMANTITL 3 PROFILINS.REF J.MOL.BIOL. V. 294 1271 1999REFN ISSN 0022-2836PMID 10600384DOI 10.1006/JMBI.1999.3318 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1elr STIP1 crystal structure of the tpr2a domain of hop in complex with the hsp90 peptide meevd 1.9Å AUTH C.SCHEUFLER,A.BRINKER,G.BOURENKOV,S.PEGORARO,AUTH 2 L.MORODER,H.BARTUNIK,F.U.HARTL,I.MOAREFITITL STRUCTURE OF TPR DOMAIN-PEPTIDE COMPLEXES:TITL 2 CRITICAL ELEMENTS IN THE ASSEMBLY OF THETITL 3 HSP70-HSP90 MULTICHAPERONE MACHINE.REF CELL(CAMBRIDGE,MASS.) V. 101 199 2000REFN ISSN 0092-8674PMID 10786835DOI 10.1016/S0092-8674(00)80830-2 Variant Set Distributions Mapped […]
General Structure Information 1imv SERPINF1 2.85 a crystal structure of pedf 2.85Å AUTH M.SIMONOVIC,P.G.GETTINS,K.VOLZTITL CRYSTAL STRUCTURE OF HUMAN PEDF, A POTENT ANTI-ANGIOGENICTITL 2 AND NEURITE GROWTH-PROMOTING FACTOR.REF PROC.NATL.ACAD.SCI.USA V. 98 11131 2001REFN ISSN 0027-8424PMID 11562499DOI 10.1073/PNAS.211268598 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2edb DCC solution structure of the fourth fibronectin type iii domain of human netrin receptor dcc -1.0Å AUTH N.TOCHIO,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FOURTH FIBRONECTIN TYPETITL 2 III DOMAIN OF HUMAN NETRIN RECEPTOR DCCREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wwy RECQL structure of human recq-like helicase in complex with a dna substrate 2.9Å AUTH A.C.W.PIKE,Y.ZHANG,C.SCHNECKE,A.CHAIKUAD,T.KROJER,AUTH 2 C.D.O.COOPER,F.VON DELFT,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.EDWARDS,C.BOUNTRA,O.GILEADITITL RECQ1 HELICASE-DRIVEN DNA UNWINDING, ANNEALING, AND BRANCHTITL 2 MIGRATION: INSIGHTS FROM DNA COMPLEX STRUCTURESREF PROC.NATL.ACAD.SCI.USA V. 112 4286 2015REFN ISSN 0027-8424PMID 25831490DOI 10.1073/PNAS.1417594112 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3rze HRH1 structure of the human histamine h1 receptor in complex with doxepin 3.1Å AUTH T.SHIMAMURA,M.SHIROISHI,S.WEYAND,H.TSUJIMOTO,G.WINTER,AUTH 2 V.KATRITCH,R.ABAGYAN,V.CHEREZOV,W.LIU,G.W.HAN,T.KOBAYASHI,AUTH 3 R.C.STEVENS,S.IWATATITL STRUCTURE OF THE HUMAN HISTAMINE H1 RECEPTOR COMPLEX WITHTITL 2 DOXEPIN.REF NATURE V. 475 65 2011REFN ISSN 0028-0836PMID 21697825DOI 10.1038/NATURE10236 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4gqs CYP2C19 structure of human microsomal cytochrome p450 (cyp) 2c19 2.87Å AUTH R.L.REYNALD,S.SANSEN,C.D.STOUT,E.F.JOHNSONTITL STRUCTURAL CHARACTERIZATION OF HUMAN CYTOCHROME P450 2C19:TITL 2 ACTIVE SITE DIFFERENCES BETWEEN P450S 2C8, 2C9, AND 2C19.REF J.BIOL.CHEM. V. 287 44581 2012REFN ISSN 0021-9258PMID 23118231DOI 10.1074/JBC.M112.424895 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1nwt CHI3L1 crystal structure of human cartilage gp39 (hc-gp39) in complex with chitopentaose 2.5Å AUTH F.FUSETTI,T.PIJNING,K.H.KALK,E.BOS,B.W.DIJKSTRATITL CRYSTAL STRUCTURE AND CARBOHYDRATE-BINDING PROPERTIES OF THETITL 2 HUMAN CARTILAGE GLYCOPROTEIN-39REF J.BIOL.CHEM. V. 278 37753 2003REFN ISSN 0021-9258PMID 12851408DOI 10.1074/JBC.M303137200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2c5d AXL structure of a minimal gas6-axl complex 3.3Å AUTH T.SASAKI,P.G.KNYAZEV,N.J.CLOUT,Y.CHEBURKIN,AUTH 2 W.GOEHRING,A.ULLRICH,R.TIMPL,E.HOHENESTERTITL STRUCTURAL BASIS FOR GAS6-AXL SIGNALLING.REF EMBO J. V. 25 80 2006REFN ISSN 0261-4189PMID 16362042DOI 10.1038/SJ.EMBOJ.7600912 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2zns GRIK1 crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, glur5, in complex with glutamate 2.0Å AUTH M.UNNO,M.SHINOHARA,K.TAKAYAMA,H.TANAKA,K.TERUYA,K.DOH-URA,AUTH 2 R.SAKAI,M.SASAKI,M.IKEDA-SAITOTITL BINDING AND SELECTIVITY OF THE MARINE TOXIN NEODYSIHERBAINETITL 2 A AND ITS SYNTHETIC ANALOGUES TO GLUK1 AND GLUK2 KAINATETITL 3 RECEPTORS.REF J.MOL.BIOL. V. 413 667 2011REFN ISSN 0022-2836PMID […]