Assessment of Structural Intolerance and Durability
General Structure Information 2fju PLCB2 activated rac1 bound to its effector phospholipase c beta 2 2.2Å AUTH M.R.JEZYK,J.T.SNYDER,S.GERSHBERG,D.K.WORTHYLAKE,AUTH 2 T.K.HARDEN,J.SONDEKTITL CRYSTAL STRUCTURE OF RAC1 BOUND TO ITS EFFECTORTITL 2 PHOSPHOLIPASE C-BETA2.REF NAT.STRUCT.MOL.BIOL. V. 13 1135 2006REFN ISSN 1545-9993PMID 17115053DOI 10.1038/NSMB1175 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ery RRAS2 the crystal structure of the ras related protein rras2 (rras2) in the gdp bound state 1.7Å AUTH E.SALAH,G.SCHOCH,A.TURNBULL,E.PAPAGRIGORIOU,M.SOUNDARARAJAN,AUTH 2 N.BURGESS,J.ELKINS,C.GILEADI,O.GILEADI,F.VON DELFT,AUTH 3 A.EDWARDS,C.ARROWSMITH,J.WEIGELT,M.SUNDSTROM,D.DOYLETITL THE CRYSTAL STRUCTURE OF THE RAS RELATED PROTEIN RRAS2TITL 2 (RRAS2) IN THE GDP BOUND STATEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2hf6 COPZ1 solution structure of human zeta-cop -1.0Å AUTH W.YU,J.LIN,C.JIN,B.XIATITL SOLUTION STRUCTURE OF HUMAN ZETA-COP: DIRECT EVIDENCES FORTITL 2 STRUCTURAL SIMILARITY BETWEEN COP I AND CLATHRIN-ADAPTORTITL 3 COATSREF J.MOL.BIOL. V. 386 903 2009REFN ISSN 0022-2836PMID 19167404DOI 10.1016/J.JMB.2008.12.083 Variant Set Distributions Mapped Variants
General Structure Information 4iyp IGBP1 structure of the npp2ac-alpha4 complex 2.8Å AUTH L.JIANG,V.STANEVICH,K.A.SATYSHUR,M.KONG,G.R.WATKINS,AUTH 2 B.E.WADZINSKI,R.SENGUPTA,Y.XINGTITL STRUCTURAL BASIS OF PROTEIN PHOSPHATASE 2A STABLE LATENCY.REF NAT COMMUN V. 4 1699 2013REFN ESSN 2041-1723PMID 23591866DOI 10.1038/NCOMMS2663 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4f52 RBX1 structure of a glomulin-rbx1-cul1 complex 3.0Å AUTH D.M.DUDA,J.L.OLSZEWSKI,A.E.TRON,M.HAMMEL,L.J.LAMBERT,AUTH 2 M.B.WADDELL,T.MITTAG,J.A.DECAPRIO,B.A.SCHULMANTITL STRUCTURE OF A GLOMULIN-RBX1-CUL1 COMPLEX: INHIBITION OF ATITL 2 RING E3 LIGASE THROUGH MASKING OF ITS E2-BINDING SURFACE.REF MOL.CELL V. 47 371 2012REFN ISSN 1097-2765PMID 22748924DOI 10.1016/J.MOLCEL.2012.05.044 Variant Set Distributions Mapped Variants
General Structure Information 3d9s AQP5 human aquaporin 5 (aqp5) – high resolution x-ray structure 2.0Å AUTH R.HORSEFIELD,K.NORDEN,M.FELLERT,A.BACKMARK,AUTH 2 S.TORNROTH-HORSEFIELD,AUTH 3 A.C.TERWISSCHA VAN SCHELTINGA,J.KVASSMAN,AUTH 4 P.KJELLBOM,U.JOHANSON,R.NEUTZETITL HIGH-RESOLUTION X-RAY STRUCTURE OF HUMAN AQUAPORINTITL 2 5REF PROC.NATL.ACAD.SCI.USA V. 105 13327 2008REFN ISSN 0027-8424PMID 18768791DOI 10.1073/PNAS.0801466105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4fmd RAB1A espg-rab1 complex structure at 3.05 a 3.05Å AUTH N.DONG,Y.ZHU,Q.LU,L.HU,Y.ZHENG,F.SHAOTITL STRUCTURALLY DISTINCT BACTERIAL TBC-LIKE GAPS LINK ARFTITL 2 GTPASE TO RAB1 INACTIVATION TO COUNTERACT HOST DEFENSES.REF CELL(CAMBRIDGE,MASS.) V. 150 1029 2012REFN ISSN 0092-8674PMID 22939626DOI 10.1016/J.CELL.2012.06.050 Variant Set Distributions Mapped Variants
General Structure Information 3cpf EIF5A crystal structure of human eukaryotic translation initiation factor eif5a 2.5Å AUTH Y.TONG,I.PARK,B.S.HONG,L.NEDYALKOVA,W.TEMPEL,H.W.PARKTITL CRYSTAL STRUCTURE OF HUMAN EIF5A1: INSIGHT INTO FUNCTIONALTITL 2 SIMILARITY OF HUMAN EIF5A1 AND EIF5A2.REF PROTEINS V. 75 1040 2009REFN ISSN 0887-3585PMID 19280598DOI 10.1002/PROT.22378 Variant Set Distributions Mapped Variants
General Structure Information 3i4r NUP107 nup107(aa658-925)/nup133(aa517-1156) complex, h.sapiens 3.53Å AUTH J.R.WHITTLE,T.U.SCHWARTZTITL ARCHITECTURAL NUCLEOPORINS NUP157/170 AND NUP133TITL 2 ARE STRUCTURALLY RELATED AND DESCEND FROM A SECONDTITL 3 ANCESTRAL ELEMENT.REF J.BIOL.CHEM. V. 284 28442 2009REFN ISSN 0021-9258PMID 19674973DOI 10.1074/JBC.M109.023580 Variant Set Distributions Mapped Variants
General Structure Information 2zu6 EIF4A1 crystal structure of the eif4a-pdcd4 complex 2.8Å AUTH J.H.CHANG,Y.H.CHO,S.Y.SOHN,J.M.CHOI,A.KIM,Y.C.KIM,AUTH 2 S.K.JANG,Y.CHOTITL CRYSTAL STRUCTURE OF THE EIF4A-PDCD4 COMPLEXREF PROC.NATL.ACAD.SCI.USA V. 106 3148 2009REFN ISSN 0027-8424PMID 19204291DOI 10.1073/PNAS.0808275106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants