Assessment of Structural Intolerance and Durability
General Structure Information 4drz RAB14 crystal structure of human rab14 2.3Å AUTH J.WANG,W.TEMPEL,C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,AUTH 2 J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB14REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2c6b MDM2 solution structure of the c4 zinc-finger domain of hdm2 -1.0Å AUTH G.W.YU,M.D.ALLEN,A.ANDREEVA,A.R.FERSHT,M.BYCROFTTITL SOLUTION STRUCTURE OF THE C4 ZINC FINGER DOMAIN OFTITL 2 HDM2.REF PROTEIN SCI. V. 15 384 2006REFN ISSN 0961-8368PMID 16385008DOI 10.1110/PS.051927306 Variant Set Distributions Mapped Variants
General Structure Information 1j1e TNNC1 crystal structure of the 52kda domain of human cardiac troponin in the ca2+ saturated form 3.3Å AUTH S.TAKEDA,A.YAMASHITA,K.MAEDA,Y.MAEDATITL STRUCTURE OF THE CORE DOMAIN OF HUMAN CARDIACTITL 2 TROPONIN IN THE CA2+-SATURATED FORMREF NATURE V. 424 35 2003REFN ISSN 0028-0836PMID 12840750DOI 10.1038/NATURE01780 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3u0d LCN2 the structure of human siderocalin bound to the bacterial siderophore 2,3-dhba 2.51Å AUTH C.CORRENTI,V.RICHARDSON,A.K.SIA,A.D.BANDARANAYAKE,M.RUIZ,AUTH 2 Y.SURYO RAHMANTO,Z.KOVACEVIC,M.C.CLIFTON,M.A.HOLMES,AUTH 3 B.K.KAISER,J.BARASCH,K.N.RAYMOND,D.R.RICHARDSON,R.K.STRONGTITL SIDEROCALIN/LCN2/NGAL/24P3 DOES NOT DRIVE APOPTOSIS THROUGHTITL 2 GENTISIC ACID MEDIATED IRON WITHDRAWAL IN HEMATOPOIETIC CELLTITL 3 LINES.REF PLOS ONE V. 7 43696 2012REFN ESSN 1932-6203PMID 22928018DOI 10.1371/JOURNAL.PONE.0043696 Variant Set Distributions Mapped […]
General Structure Information 1qb2 SRP54 crystal structure of the conserved subdomain of human protein srp54m at 2.1a resolution: evidence for the mechanism of signal peptide binding 2.1Å AUTH W.M.CLEMONS JR.,K.GOWDA,S.D.BLACK,C.ZWIEB,AUTH 2 V.RAMAKRISHNANTITL CRYSTAL STRUCTURE OF THE CONSERVED SUBDOMAIN OFTITL 2 HUMAN PROTEIN SRP54M AT 2.1 A RESOLUTION: EVIDENCETITL 3 FOR THE MECHANISM OF SIGNAL PEPTIDE […]
General Structure Information 4js0 CDC42 complex of cdc42 with the crib-pr domain of irsp53 1.9Å AUTH D.J.KAST,C.YANG,A.DISANZA,M.BOCZKOWSKA,Y.MADASU,G.SCITA,AUTH 2 T.SVITKINA,R.DOMINGUEZTITL MECHANISM OF IRSP53 INHIBITION AND COMBINATORIAL ACTIVATIONTITL 2 BY CDC42 AND DOWNSTREAM EFFECTORS.REF NAT.STRUCT.MOL.BIOL. V. 21 413 2014REFN ISSN 1545-9993PMID 24584464DOI 10.1038/NSMB.2781 Variant Set Distributions Mapped Variants
General Structure Information 2ht6 GEM crystal structure of human gem g-domain bound to gdp 2.4Å AUTH Y.OPATOWSKY,Y.SASSON,I.SHAKED,Y.WARD,AUTH 2 O.CHOMSKY-HECHT,Y.LITVAK,Z.SELINGER,K.KELLY,AUTH 3 J.A.HIRSCHTITL STRUCTURE-FUNCTION STUDIES OF THE G-DOMAIN FROMTITL 2 HUMAN GEM, A NOVEL SMALL G-PROTEIN.REF FEBS LETT. V. 580 5959 2006REFN ISSN 0014-5793PMID 17052716DOI 10.1016/J.FEBSLET.2006.09.067 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3u9c CSNK2A1 structure of a c-terminal deletion mutant of human protein kinase ck2 catalytic subunit with the atp-competitive inhibitor resorufin 3.2Å AUTH K.KLOPFFLEISCH,O.G.ISSINGER,K.NIEFINDTITL LOW-DENSITY CRYSTAL PACKING OF HUMAN PROTEIN KINASE CK2TITL 2 CATALYTIC SUBUNIT IN COMPLEX WITH RESORUFIN OR OTHERTITL 3 LIGANDS: A TOOL TO STUDY THE UNIQUE HINGE-REGION PLASTICITYTITL 4 OF […]
General Structure Information 3oe8 CXCR4 crystal structure of the cxcr4 chemokine receptor in complex with a small molecule antagonist it1t in p1 spacegroup 3.1Å AUTH B.WU,E.Y.CHIEN,C.D.MOL,G.FENALTI,W.LIU,V.KATRITCH,R.ABAGYAN,AUTH 2 A.BROOUN,P.WELLS,F.C.BI,D.J.HAMEL,P.KUHN,T.M.HANDEL,AUTH 3 V.CHEREZOV,R.C.STEVENSTITL STRUCTURES OF THE CXCR4 CHEMOKINE GPCR WITH SMALL-MOLECULETITL 2 AND CYCLIC PEPTIDE ANTAGONISTS.REF SCIENCE V. 330 1066 2010REFN ISSN 0036-8075PMID 20929726DOI 10.1126/SCIENCE.1194396 Variant Set Distributions […]
General Structure Information 2e8p ELF3 solution structure of the n-terminal sam-domain of e74-like factor 3 -1.0Å AUTH A.K.GORONCY,M.SATO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERMINAL SAM-DOMAIN OFTITL 2 E74-LIKE FACTOR 3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants