Assessment of Structural Intolerance and Durability
General Structure Information 3jui EIF2B5 crystal structure of the c-terminal domain of human translation initiation factor eif2b epsilon subunit 2.0Å AUTH J.WEI,H.XU,C.ZHANG,M.WANG,F.GAO,W.GONGTITL CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMANTITL 2 TRANSLATION INITIATION FACTOR EIF2B EPSILON SUBUNITREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2oo4 NOTCH2 structure of lnr-hd (negative regulatory region) from human notch 2 2.0Å AUTH W.R.GORDON,D.VARDAR-ULU,G.HISTEN,C.SANCHEZ-IRIZARRY,AUTH 2 J.C.ASTER,S.C.BLACKLOWTITL STRUCTURAL BASIS FOR AUTOINHIBITION OF NOTCHREF NAT.STRUCT.MOL.BIOL. V. 14 295 2007REFN ISSN 1545-9993PMID 17401372DOI 10.1038/NSMB1227 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1yse SATB1 solution structure of the mar-binding domain of satb1 -1.0Å AUTH H.YAMAGUCHI,M.TATENO,K.YAMASAKITITL SOLUTION STRUCTURE AND DNA-BINDING MODE OF THETITL 2 MATRIX ATTACHMENT REGION-BINDING DOMAIN OF THETITL 3 TRANSCRIPTION FACTOR SATB1 THAT REGULATES THETITL 4 T-CELL MATURATIONREF J.BIOL.CHEM. V. 281 5319 2006REFN ISSN 0021-9258PMID 16371359DOI 10.1074/JBC.M510933200 Variant Set Distributions Mapped Variants
General Structure Information 2k27 PAX8 solution structure of human pax8 paired box domain -1.0Å AUTH L.CODUTTI,H.VAN INGEN,C.VASCOTTO,F.FOGOLARI,AUTH 2 A.CORAZZA,G.TELL,F.QUADRIFOGLIO,P.VIGLINO,AUTH 3 R.BOELENS,G.ESPOSITOTITL THE SOLUTION STRUCTURE OF DNA-FREE PAX-8 PAIRED BOXTITL 2 DOMAIN ACCOUNTS FOR REDOX REGULATION OFTITL 3 TRANSCRIPTIONAL ACTIVITY IN THE PAX PROTEIN FAMILY.REF J.BIOL.CHEM. V. 283 33321 2008REFN ISSN 0021-9258PMID 18829450DOI 10.1074/JBC.M805717200 Variant Set […]
General Structure Information 2enj PRKCQ solution sturcture of the c2 domain from human protein kinase c theta -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STURCTURE OF THE C2 DOMAIN FROM HUMANTITL 2 PROTEIN KINASE C THETAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1u3b APBA1 auto-inhibition mechanism of x11s/mints family scaffold proteins revealed by the closed conformation of the tandem pdz domains -1.0Å AUTH J.-F.LONG,W.FENG,R.WANG,L.-N.CHAN,F.C.IP,J.XIA,AUTH 2 N.Y.IP,M.ZHANGTITL AUTOINHIBITION OF X11/MINT SCAFFOLD PROTEINSTITL 2 REVEALED BY THE CLOSED CONFORMATION OF THE PDZTITL 3 TANDEMREF NAT.STRUCT.MOL.BIOL. V. 12 722 2005REFN ISSN 1545-9993PMID 16007100DOI 10.1038/NSMB958 Variant Set Distributions […]
General Structure Information 3ks9 GRM1 metabotropic glutamate receptor mglur1 complexed with ly341495 antagonist 1.9Å AUTH E.DOBROVETSKY,G.KHUTORESKAYA,A.SEITOVA,D.COSSAR,A.M.EDWARDS,AUTH 2 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,A.BOCHKAREVTITL METABOTROPIC GLUTAMATE RECEPTOR MGLUR1 COMPLEXED WITHTITL 2 LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4n6j STRN3 crystal structure of human striatin-3 coiled coil domain 2.0Å AUTH C.C.CHEN,Z.B.SHI,W.Q.ZHANG,M.CHEN,F.HE,Z.Z.ZHANG,Y.C.WANG,AUTH 2 M.FENG,W.J.WANG,Y.ZHAO,J.H.BROWN,S.JIAO,Z.C.ZHOUTITL STRIATINS CONTAIN A NONCANONICAL COILED COIL THAT BINDS PP2ATITL 2 A TO FORM A 2:2 HETEROTETRAMERIC CORE OFTITL 3 STRIATIN-INTERACTING PHOSPHATASE AND KINASE (STRIPAK)TITL 4 COMPLEXREF J.BIOL.CHEM. 2014REFN ESSN 1083-351XDOI 10.1074/JBC.M113.529297 Variant Set Distributions Mapped Variants
General Structure Information 1cf4 TNK2 cdc42/ack gtpase-binding domain complex -1.0Å AUTH H.R.MOTT,D.OWEN,D.NIETLISPACH,P.N.LOWE,E.MANSER,AUTH 2 L.LIM,E.D.LAUETITL STRUCTURE OF THE SMALL G PROTEIN CDC42 BOUND TOTITL 2 THE GTPASE-BINDING DOMAIN OF ACK.REF NATURE V. 399 384 1999REFN ISSN 0028-0836PMID 10360579DOI 10.1038/20732 Variant Set Distributions Mapped Variants
General Structure Information 3h3g PTH1R crystal structure of the extracellular domain of the human parathyroid hormone receptor (pth1r) in complex with parathyroid hormone-related protein (pthrp) 1.94Å AUTH A.A.PIOSZAK,N.R.PARKER,T.J.GARDELLA,H.E.XUTITL STRUCTURAL BASIS FOR PARATHYROID HORMONE-RELATED PROTEINTITL 2 BINDING TO THE PARATHYROID HORMONE RECEPTOR AND DESIGN OFTITL 3 CONFORMATION-SELECTIVE PEPTIDES.REF J.BIOL.CHEM. V. 284 28382 2009REFN ISSN 0021-9258PMID 19674967DOI […]