Assessment of Structural Intolerance and Durability
General Structure Information 2m0r S100A14 solution structure and dynamics of human s100a14 -1.0Å AUTH I.BERTINI,V.BORSI,L.CEROFOLINI,S.DAS GUPTA,M.FRAGAI,AUTH 2 C.LUCHINATTITL SOLUTION STRUCTURE AND DYNAMICS OF HUMAN S100A14.REF J.BIOL.INORG.CHEM. V. 18 183 2013REFN ISSN 0949-8257PMID 23197251DOI 10.1007/S00775-012-0963-3 Variant Set Distributions Mapped Variants
General Structure Information 2pz1 ARHGEF4 crystal structure of auto-inhibited asef 2.25Å AUTH N.MITIN,L.BETTS,M.E.YOHE,C.J.DER,J.SONDEK,K.L.ROSSMANTITL RELEASE OF AUTOINHIBITION OF ASEF BY APC LEADS TO CDC42TITL 2 ACTIVATION AND TUMOR SUPPRESSION.REF NAT.STRUCT.MOL.BIOL. V. 14 814 2007REFN ISSN 1545-9993PMID 17704816DOI 10.1038/NSMB1290 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3q2e BRWD1 crystal structure of the second bromodomain of human bromodomain and wd repeat-containing protein 1 isoform a (wdr9) 1.74Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 1x5w ZFP64 solution structure of the c2h2 type zinc-binding domain of human zinc finger protein 64, isoforms 1 and 2 -1.0Å AUTH M.YONEYAMA,S.KOSHIBA,N.TOCHIO,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC-BINDINGTITL 2 DOMAIN OF HUMAN ZINC FINGER PROTEIN 64, ISOFORMS 1TITL 3 AND 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s […]
General Structure Information 2dmd ZFP64 solution structure of the n-terminal c2h2 type zinc-binding domain of the zinc finger protein 64, isoforms 1 and 2 -1.0Å AUTH M.YONEYAMA,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERMINAL C2H2 TYPETITL 2 ZINC-BINDING DOMAIN OF THE ZINC FINGER PROTEIN 64,TITL 3 ISOFORMS 1 AND 2REF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 3iwp CUTC crystal structure of human copper homeostasis protein cutc 2.5Å AUTH Y.LI,J.DU,P.ZHANG,J.DINGTITL CRYSTAL STRUCTURE OF HUMAN COPPER HOMEOSTASISTITL 2 PROTEIN CUTC REVEALS A POTENTIAL COPPER-BINDINGTITL 3 SITEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2kea SAMSN1 nmr solution structure of the hacs1 sh3 domain -1.0Å AUTH L.DONALDSONTITL NMR SOLUTION STRUCTURE OF THE HACS1 SH3 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2eqx KBTBD4 solution structure of the back domain of kelch repeat and btb domain-containing protein 4 -1.0Å AUTH M.IMAI,S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE BACK DOMAIN OF KELCHTITL 2 REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1wvo NANS solution structure of rsgi ruh-029, an antifreeze protein like domain in human n-acetylneuraminic acid phosphate synthase gene. -1.0Å AUTH T.HAMADA,Y.ITO,T.ABE,F.HAYASHI,P.GUNTERT,M.INOUE,AUTH 2 T.KIGAWA,T.TERADA,M.SHIROUZU,M.YOSHIDA,A.TANAKA,AUTH 3 S.SUGANO,S.YOKOYAMA,H.HIROTATITL SOLUTION STRUCTURE OF THE ANTIFREEZE-LIKE DOMAINTITL 2 OF HUMAN SIALIC ACID SYNTHASEREF PROTEIN SCI. V. 15 1010 2006REFN ISSN 0961-8368PMID 16597820DOI 10.1110/PS.051700406 Variant Set Distributions Mapped […]
General Structure Information 4edj GORASP2 crystal structure of the grasp55 grasp domain with a phosphomimetic mutation (s189d) 1.9Å AUTH S.T.TRUSCHEL,M.ZHANG,C.BACHERT,M.R.MACBETH,A.D.LINSTEDTTITL ALLOSTERIC REGULATION OF GRASP PROTEIN-DEPENDENT GOLGITITL 2 MEMBRANE TETHERING BY MITOTIC PHOSPHORYLATION.REF J.BIOL.CHEM. V. 287 19870 2012REFN ISSN 0021-9258PMID 22523075DOI 10.1074/JBC.M111.326256 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]