Assessment of Structural Intolerance and Durability
General Structure Information 2odd RUNX1T1 solution structure of the mynd domain from aml1-eto complexed with smrt, a corepressor -1.0Å AUTH Y.LIU,W.CHEN,J.GAUDET,M.D.CHENEY,L.ROUDAIA,AUTH 2 T.CIERPICKI,R.C.KLET,K.HARTMAN,T.M.LAUE,N.A.SPECK,AUTH 3 J.H.BUSHWELLERTITL STRUCTURAL BASIS FOR RECOGNITION OF SMRT/N-COR BYTITL 2 THE MYND DOMAIN AND ITS CONTRIBUTION TO AML1/ETOSTITL 3 ACTIVITY.REF CANCER CELL V. 11 483 2007REFN ISSN 1535-6108PMID 17560331DOI 10.1016/J.CCR.2007.04.010 Variant Set […]
General Structure Information 2jjs CD47 structure of human cd47 in complex with human signal regulatory protein (sirp) alpha 1.85Å AUTH D.HATHERLEY,S.C.GRAHAM,J.TURNER,K.HARLOS,AUTH 2 D.I.STUART,A.N.BARCLAYTITL PAIRED RECEPTOR SPECIFICITY EXPLAINED BYTITL 2 STRUCTURES OF SIGNAL REGULATORY PROTEINS ALONE ANDTITL 3 COMPLEXED WITH CD47.REF MOL.CELL V. 31 266 2008REFN ISSN 1097-2765PMID 18657508DOI 10.1016/J.MOLCEL.2008.05.026 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1uhl NR1H3 crystal structure of the lxralfa-rxrbeta lbd heterodimer 2.9Å AUTH S.SVENSSON,T.OSTBERG,M.JACOBSSON,C.NORSTROM,AUTH 2 K.STEFANSSON,D.HALLEN,I.C.JOHANSSON,K.ZACHRISSON,AUTH 3 D.OGG,L.JENDEBERGTITL CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OFTITL 2 LXRALPHA AND RXRBETA LIGAND-BINDING DOMAINS IN ATITL 3 FULLY AGONISTIC CONFORMATIONREF EMBO J. V. 22 4625 2003REFN ISSN 0261-4189PMID 12970175DOI 10.1093/EMBOJ/CDG456 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1fqv SKP2 insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex 2.8Å AUTH B.A.SCHULMAN,A.C.CARRANO,P.D.JEFFREY,Z.BOWEN,AUTH 2 E.R.KINNUCAN,M.S.FINNIN,S.J.ELLEDGE,J.W.HARPER,AUTH 3 M.PAGANO,N.P.PAVLETICHTITL INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THETITL 2 STRUCTURE OF THE SKP1-SKP2 COMPLEX.REF NATURE V. 408 381 2000REFN ISSN 0028-0836PMID 11099048DOI 10.1038/35042620 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3cyy TJP1 the crystal structure of zo-1 pdz2 in complex with the cx43 peptide 2.4Å AUTH J.CHEN,L.PAN,Z.WEI,Y.ZHAO,M.ZHANGTITL DOMAIN-SWAPPED DIMERIZATION OF ZO-1 PDZ2 GENERATES SPECIFICTITL 2 AND REGULATORY CONNEXIN43-BINDING SITESREF EMBO J. V. 27 2113 2008REFN ISSN 0261-4189PMID 18636092DOI 10.1038/EMBOJ.2008.138 Variant Set Distributions Mapped Variants
General Structure Information 3ull SSBP1 human mitochondrial single-stranded dna binding protein 2.4Å AUTH C.YANG,U.CURTH,C.URBANKE,C.KANGTITL CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIALTITL 2 SINGLE-STRANDED DNA BINDING PROTEIN AT 2.4 ATITL 3 RESOLUTION.REF NAT.STRUCT.BIOL. V. 4 153 1997REFN ISSN 1072-8368PMID 9033597DOI 10.1038/NSB0297-153 Variant Set Distributions Mapped Variants
General Structure Information 1jj7 TAP1 crystal structure of the c-terminal atpase domain of human tap1 2.4Å AUTH R.GAUDET,D.C.WILEYTITL STRUCTURE OF THE ABC ATPASE DOMAIN OF HUMAN TAP1,TITL 2 THE TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING.REF EMBO J. V. 20 4964 2001REFN ISSN 0261-4189PMID 11532960DOI 10.1093/EMBOJ/20.17.4964 Variant Set Distributions Mapped Variants
General Structure Information 2kyg RUNX1T1 structure of the aml1-eto nervy domain – pka(riia) complex and its contribution to aml1-eto activity -1.0Å AUTH T.CORPORA,L.ROUDAIA,Z.M.OO,W.CHEN,E.MANUYLOVA,X.CAI,AUTH 2 M.J.CHEN,T.CIERPICKI,N.A.SPECK,J.H.BUSHWELLERTITL STRUCTURE OF THE AML1-ETO NHR3-PKA(RIIALPHA) COMPLEX AND ITSTITL 2 CONTRIBUTION TO AML1-ETO ACTIVITY.REF J.MOL.BIOL. V. 402 560 2010REFN ISSN 0022-2836PMID 20708017DOI 10.1016/J.JMB.2010.08.007 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2rs9 BRPF1 solution structure of the bromodomain of human brpf1 in complex with histone h4k5ac peptide -1.0Å AUTH X.QIN,F.HAYASHI,S.YOKOYAMATITL SITE-SPECIFIC HISTONE RECOGNITION BY THE BROMODOMAIN OFTITL 2 BRPF1 AND THE ROLE IN MOZ/MORF HISTONE ACETYLTRANSFERASETITL 3 COMPLEXESREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2fv8 RHOB the crystal structure of rhob in the gdp-bound state 1.9Å AUTH A.P.TURNBULL,M.SOUNDARARAJAN,C.SMEE,C.JOHANSSON,G.SCHOCH,AUTH 2 F.GORREC,J.BRAY,E.PAPAGRIGORIOU,F.VON DELFT,J.WEIGELT,AUTH 3 A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,D.DOYLETITL THE CRYSTAL STRUCTURE OF RHOB IN THE GDP-BOUND STATEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants