Assessment of Structural Intolerance and Durability
General Structure Information 2p8q KPNB1 crystal structure of human importin beta bound to the snurportin1 ibb- domain 2.35Å AUTH G.MITROUSIS,A.S.OLIA,N.WALKER-KOPP,G.CINGOLANITITL MOLECULAR BASIS FOR THE RECOGNITION OF SNURPORTIN 1 BYTITL 2 IMPORTIN {BETA}.REF J.BIOL.CHEM. V. 283 7877 2008REFN ISSN 0021-9258PMID 18187419DOI 10.1074/JBC.M709093200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2efk TRIP10 crystal structure of the efc domain of cdc42-interacting protein 4 2.3Å AUTH A.SHIMADA,H.NIWA,K.TSUJITA,S.SUETSUGU,K.NITTA,AUTH 2 K.HANAWA-SUETSUGU,R.AKASAKA,Y.NISHINO,M.TOYAMA,L.CHEN,AUTH 3 Z.-J.LIU,B.-C.WANG,M.YAMAMOTO,T.TERADA,A.MIYAZAWA,A.TANAKA,AUTH 4 S.SUGANO,M.SHIROUZU,K.NAGAYAMA,T.TAKENAWA,S.YOKOYAMATITL CURVED EFC/F-BAR-DOMAIN DIMERS ARE JOINED END TO END INTO ATITL 2 FILAMENT FOR MEMBRANE INVAGINATION IN ENDOCYTOSISREF CELL(CAMBRIDGE,MASS.) V. 129 761 2007REFN ISSN 0092-8674PMID 17512409DOI 10.1016/J.CELL.2007.03.040 Variant Set Distributions Ripley’s K […]
General Structure Information 2axl WRN solution structure of a multifunctional dna- and protein- binding domain of human werner syndrome protein -1.0Å AUTH J.-S.HU,H.FENG,W.ZENG,G.-X.LIN,X.G.XITITL SOLUTION STRUCTURE OF A MULTIFUNCTIONAL DNA- ANDTITL 2 PROTEIN-BINDING MOTIF OF HUMAN WERNER SYNDROMETITL 3 PROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 102 18379 2005REFN ISSN 0027-8424PMID 16339893DOI 10.1073/PNAS.0509380102 Variant Set Distributions Mapped Variants
General Structure Information 4o9b STIM1 the structure of cc1-ih in human stim1. 2.6Å AUTH B.CUI,X.YANG,S.LI,Z.LIN,Z.WANG,C.DONG,Y.SHENTITL THE INHIBITORY HELIX CONTROLS THE INTRAMOLECULARTITL 2 CONFORMATIONAL SWITCHING OF THE C-TERMINUS OF STIM1.REF PLOS ONE V. 8 74735 2013REFN ESSN 1932-6203PMID 24069340DOI 10.1371/JOURNAL.PONE.0074735 Variant Set Distributions Mapped Variants
General Structure Information 3i35 LASP1 human sh3 domain of protein lasp1 1.4Å AUTH M.I.SIPONEN,A.K.ROOS,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T KOTENYOVA,A.KOTZSCH,T.KRAGH NIELSEN,M.MOCHE,T.NYMAN,AUTH 5 C.PERSSON,J.SAGEMARK,H.SCHUELER,P.SCHUTZ,A.G.THORSELL,AUTH 6 L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,AUTH 7 P.NORDLUNDTITL HUMAN SH3 DOMAIN OF PROTEIN LASP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3f7p PLEC crystal structure of a complex between integrin beta4 and plectin 2.75Å AUTH J.M.DE PEREDA,M.P.LILLO,A.SONNENBERGTITL STRUCTURAL BASIS OF THE INTERACTION BETWEENTITL 2 INTEGRIN ALPHA6BETA4 AND PLECTIN AT THETITL 3 HEMIDESMOSOMESREF EMBO J. V. 28 1180 2009REFN ISSN 0261-4189PMID 19242489DOI 10.1038/EMBOJ.2009.48 Variant Set Distributions Mapped Variants
General Structure Information 2bzl PTPN14 crystal structure of the human protein tyrosine phosphatase n14 at 1.65 a resolution 1.65Å AUTH A.J.BARR,J.E.DEBRECZENI,J.ESWARAN,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINETITL 2 PHOSPHATASE 14 (PTPN14) AT 1.65-A RESOLUTION.REF PROTEINS V. 63 1132 2006REFN ISSN 0887-3585PMID 16534812DOI 10.1002/PROT.20958 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1x6d IL16 solution structures of the pdz domain of human interleukin- 16 -1.0Å AUTH M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE PDZ DOMAIN OF HUMANTITL 2 INTERLEUKIN-16REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4a4p CYTH1 crystal structure of the sec7 domain from human cytohesin1 2.0Å AUTH J.C.ZEEH,A.W.THOMPSON,J.CHERFILS,V.BIOUTITL CRYSTAL STRUCTURE OF THE SEC7 DOMAIN FROM HUMAN CYTOHESIN1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3aih OS9 human os-9 mrh domain complexed with alpha3,alpha6-man5 2.1Å AUTH T.SATOH,Y.CHEN,D.HU,S.HANASHIMA,K.YAMAMOTO,Y.YAMAGUCHITITL STRUCTURAL BASIS FOR OLIGOSACCHARIDE RECOGNITION OFTITL 2 MISFOLDED GLYCOPROTEINS BY OS-9 IN ER-ASSOCIATED DEGRADATIONREF MOL.CELL V. 40 905 2010REFN ISSN 1097-2765PMID 21172656DOI 10.1016/J.MOLCEL.2010.11.017 Variant Set Distributions Mapped Variants