Assessment of Structural Intolerance and Durability
General Structure Information 2fi2 MZF1 solution structure of the scan homodimer from mzf-1/znf42 -1.0Å AUTH F.C.PETERSON,P.L.HAYES,J.K.WALTNER,A.K.HEISNER,AUTH 2 D.R.JENSEN,T.L.SANDER,B.F.VOLKMANTITL STRUCTURE OF THE SCAN DOMAIN FROM THE TUMORTITL 2 SUPPRESSOR PROTEIN MZF1.REF J.MOL.BIOL. V. 363 137 2006REFN ISSN 0022-2836PMID 16950398DOI 10.1016/J.JMB.2006.07.063 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2qbx EPHB2 ephb2/snew antagonistic peptide complex 2.3Å AUTH J.E.CHRENCIK,A.BROOUN,M.I.RECHT,G.NICOLA,L.K.DAVIS,AUTH 2 R.ABAGYAN,H.WIDMER,E.B.PASQUALE,P.KUHNTITL THREE-DIMENSIONAL STRUCTURE OF THE EPHB2 RECEPTORTITL 2 IN COMPLEX WITH AN ANTAGONISTIC PEPTIDE REVEALS ATITL 3 NOVEL MODE OF INHIBITION.REF J.BIOL.CHEM. V. 282 36505 2007REFN ISSN 0021-9258PMID 17897949DOI 10.1074/JBC.M706340200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1tuz DGKA nmr structure of the diacylglycerol kinase alpha, nesgc target hr532 -1.0Å AUTH G.LIU,Y.SHAO,R.XIAO,T.ACTON,G.T.MONTELIONE,AUTH 2 T.SZYPERSKITITL NMR STRUCTURE OF DIACYLGLYCEROL KINASE ALPHA,TITL 2 NESGC TARGET HR532REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3qak ADORA2A agonist bound structure of the human adenosine a2a receptor 2.71Å AUTH F.XU,H.WU,V.KATRITCH,G.W.HAN,K.A.JACOBSON,Z.G.GAO,AUTH 2 V.CHEREZOV,R.C.STEVENSTITL STRUCTURE OF AN AGONIST-BOUND HUMAN A2A ADENOSINE RECEPTOR.REF SCIENCE V. 332 322 2011REFN ISSN 0036-8075PMID 21393508DOI 10.1126/SCIENCE.1202793 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4dnl PRKCA crystal structure of a c2 domain of a protein kinase c alpha (prkca) from homo sapiens at 1.90 a resolution 1.9Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL CRYSTAL STRUCTURE OF A C2 DOMAIN OF A PROTEIN KINASE C ALPHATITL 2 (PRKCA) FROM HOMO […]
General Structure Information 1z6x ARF4 structure of human adp-ribosylation factor 4 2.7Å AUTH A.ATANASSOVA,J.CHOE,C.ARROWSMITH,A.EDWARDS,AUTH 2 M.SUNDSTROM,A.BOCHKAREV,H.PARKTITL STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3lhr ZNF24 crystal structure of the scan domain from human znf24 1.9Å AUTH B.F.VOLKMAN,F.C.PETERSON,C.A.BINGMAN,G.N.PHILLIPS JR.TITL CRYSTAL STRUCTURE OF THE SCAN DOMAIN FROM HUMAN ZNF24REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2q4g RNH1 ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i 1.95Å AUTH R.J.JOHNSON,J.G.MCCOY,C.A.BINGMAN,G.N.PHILLIPS JR.,AUTH 2 R.T.RAINESTITL INHIBITION OF HUMAN PANCREATIC RIBONUCLEASE BY THE HUMANTITL 2 RIBONUCLEASE INHIBITOR PROTEIN.REF J.MOL.BIOL. V. 368 434 2007REFN ISSN 0022-2836PMID 17350650DOI 10.1016/J.JMB.2007.02.005 Variant Set Distributions Mapped Variants
General Structure Information 3uf1 VIM crystal structure of vimentin (fragment 144-251) from homo sapiens, northeast structural genomics consortium target hr4796b 2.81Å AUTH A.AZIZ,J.F.HESS,M.S.BUDAMAGUNTA,J.C.VOSS,A.P.KUZIN,AUTH 2 Y.J.HUANG,R.XIAO,G.T.MONTELIONE,P.G.FITZGERALD,J.F.HUNTTITL THE STRUCTURE OF VIMENTIN LINKER 1 AND ROD 1B DOMAINSTITL 2 CHARACTERIZED BY SITE-DIRECTED SPIN-LABELING ELECTRONTITL 3 PARAMAGNETIC RESONANCE (SDSL-EPR) AND X-RAY CRYSTALLOGRAPHY.REF J.BIOL.CHEM. V. 287 28349 2012REFN ISSN 0021-9258PMID […]
General Structure Information 4d8k LCK crystal structure of a sh3-sh2 domains of a lymphocyte-specific protein tyrosine kinase (lck) from homo sapiens at 2.36 a resolution 2.36Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGYTITL CRYSTAL STRUCTURE OF A SH3-SH2 DOMAINS OF ATITL 2 LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE (LCK) FROM HOMOTITL 3 […]