Assessment of Structural Intolerance and Durability
General Structure Information 4gul PIR study on structure and function relationships in human ferric pirin 1.8Å AUTH F.LIU,I.REHMANI,S.ESAKI,R.FU,L.CHEN,V.DE SERRANO,A.LIUTITL PIRIN IS AN IRON-DEPENDENT REDOX REGULATOR OF NF-KAPPA B.REF PROC.NATL.ACAD.SCI.USA V. 110 9722 2013REFN ISSN 0027-8424PMID 23716661DOI 10.1073/PNAS.1221743110 Variant Set Distributions Mapped Variants
General Structure Information 3d8f APBB1 crystal structure of the human fe65-ptb1 domain with bound phosphate (trigonal crystal form) 2.7Å AUTH J.RADZIMANOWSKI,S.RAVAUD,S.SCHLESINGER,J.KOCH,AUTH 2 K.BEYREUTHER,I.SINNING,K.WILDTITL CRYSTAL STRUCTURE OF THE HUMAN FE65-PTB1 DOMAIN.REF J.BIOL.CHEM. V. 283 23113 2008REFN ISSN 0021-9258PMID 18550529DOI 10.1074/JBC.M800861200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1wlx ACTN4 solution structure of the third spectrin repeat of alpha- actinin-4 -1.0Å AUTH K.KOWALSKI,A.L.MERKEL,G.W.BOOKERTITL SOLUTION STRUCTURE OF THE THIRD SPECTRIN REPEAT OFTITL 2 ALPHA-ACTININ-4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2f60 PDHX crystal structure of the dihydrolipoamide dehydrogenase (e3)-binding domain of human e3-binding protein 1.55Å AUTH C.A.BRAUTIGAM,R.M.WYNN,J.L.CHUANG,M.MACHIUS,D.R.TOMCHICK,AUTH 2 D.T.CHUANGTITL STRUCTURAL INSIGHT INTO INTERACTIONS BETWEENTITL 2 DIHYDROLIPOAMIDE DEHYDROGENASE (E3) AND E3 BINDING PROTEINTITL 3 OF HUMAN PYRUVATE DEHYDROGENASE COMPLEX.REF STRUCTURE V. 14 611 2006REFN ISSN 0969-2126PMID 16442803DOI 10.1016/J.STR.2006.01.001 Variant Set Distributions Mapped Variants
General Structure Information 1wie RIMBP2 solution structure of the first sh3 domain of kiaa0318 protein -1.0Å AUTH K.INOUE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST SH3 DOMAIN OFTITL 2 KIAA0318 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2kkr ATXN7 solution structure of sca7 zinc finger domain from human ataxin-7 protein -1.0Å AUTH J.BONNET,Y.WANG,A.ATKINSON,J.KOFFLER,C.ROMIER,A.HAMICHE,AUTH 2 L.TORA,D.DEVYS,B.KIEFFERTITL HISTONE DEUBIQUITINATION BY SAGA IS MODULATED BY ANTITL 2 ATYPICAL ZINC FINGER DOMAIN OF ATAXIN-7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1szb MASP2 crystal structure of the human mbl-associated protein 19 (map19) 2.5Å AUTH L.A.GREGORY,N.M.THIELENS,M.MATSUSHITA,R.SORENSEN,AUTH 2 G.J.ARLAUD,J.C.FONTECILLA-CAMPS,C.GABORIAUDTITL THE X-RAY STRUCTURE OF HUMAN MBL-ASSOCIATEDTITL 2 PROTEIN 19 (MAP19) AND ITS INTERACTION SITE WITHTITL 3 MANNAN-BINDING LECTIN AND L-FICOLINREF J.BIOL.CHEM. V. 279 29391 2004REFN ISSN 0021-9258PMID 15117939DOI 10.1074/JBC.M402687200 Variant Set Distributions Mapped Variants
General Structure Information 1kgd CASK crystal structure of the guanylate kinase-like domain of human cask 1.31Å AUTH Y.LI,O.SPANGENBERG,I.PAARMANN,M.KONRAD,A.LAVIETITL STRUCTURAL BASIS FOR NUCLEOTIDE-DEPENDENTTITL 2 REGULATION OF MEMBRANE-ASSOCIATED GUANYLATETITL 3 KINASE-LIKE DOMAINS.REF J.BIOL.CHEM. V. 277 4159 2002REFN ISSN 0021-9258PMID 11729206DOI 10.1074/JBC.M110792200 Variant Set Distributions Mapped Variants
General Structure Information 3v30 RFXANK crystal structure of the peptide bound complex of the ankyrin repeat domains of human rfxank 1.57Å AUTH C.XU,J.JIN,C.BIAN,R.LAM,R.TIAN,R.WEIST,L.YOU,J.NIE,AUTH 2 A.BOCHKAREV,W.TEMPEL,C.S.TAN,G.A.WASNEY,M.VEDADI,G.D.GISH,AUTH 3 C.H.ARROWSMITH,T.PAWSON,X.J.YANG,J.MINTITL SEQUENCE-SPECIFIC RECOGNITION OF A PXLPXI/L MOTIF BY ANTITL 2 ANKYRIN REPEAT TUMBLER LOCK.REF SCI.SIGNAL. V. 5 RA39 2012REFN ESSN 1937-9145PMID 22649097DOI 10.1126/SCISIGNAL.2002979 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4e6r NCK2 crystal structure of a cytoplasmic protein nck2 (nck2) from homo sapiens at 2.20 a resolution 2.2Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL CRYSTAL STRUCTURE OF A CYTOPLASMIC PROTEIN NCK2 (NCK2) FROMTITL 2 HOMO SAPIENS AT 2.20 A RESOLUTIONREF TO BE PUBLISHEDREFN Variant Set […]