Assessment of Structural Intolerance and Durability
General Structure Information 1rn7 CST5 structure of human cystatin d 2.5Å AUTH M.ALVAREZ-FERNANDEZ,Y.H.LIANG,M.ABRAHAMSON,X.D.SUTITL CRYSTAL STRUCTURE OF HUMAN CYSTATIN D, A CYSTEINETITL 2 PEPTIDASE INHIBITOR WITH RESTRICTED INHIBITIONTITL 3 PROFILE.REF J.BIOL.CHEM. V. 280 18221 2005REFN ISSN 0021-9258PMID 15728581DOI 10.1074/JBC.M411914200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4luo RPA1 fragment-based discovery of a potent inhibitor of replication protein a protein-protein interactions 1.54Å AUTH A.O.FRANK,M.D.FELDKAMP,J.P.KENNEDY,A.G.WATERSON,N.F.PELZ,AUTH 2 J.D.PATRONE,B.VANGAMUDI,D.V.CAMPER,O.W.ROSSANESE,W.J.CHAZIN,AUTH 3 S.W.FESIKTITL DISCOVERY OF A POTENT INHIBITOR OF REPLICATION PROTEIN ATITL 2 PROTEIN-PROTEIN INTERACTIONS USING A FRAGMENT-LINKINGTITL 3 APPROACH.REF J.MED.CHEM. V. 56 9242 2013REFN ISSN 0022-2623PMID 24147804DOI 10.1021/JM401333U Variant Set Distributions Mapped Variants
General Structure Information 3szr MX1 crystal structure of modified nucleotide-free human mxa 3.5Å AUTH S.GAO,A.VON DER MALSBURG,A.DICK,K.FAELBER,G.F.SCHRODER,AUTH 2 O.HALLER,G.KOCHS,O.DAUMKETITL STRUCTURE OF MYXOVIRUS RESISTANCE PROTEIN A REVEALS INTRA-TITL 2 AND INTERMOLECULAR DOMAIN INTERACTIONS REQUIRED FOR THETITL 3 ANTIVIRAL FUNCTION.REF IMMUNITY V. 35 514 2011REFN ISSN 1074-7613PMID 21962493DOI 10.1016/J.IMMUNI.2011.07.012 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1uc6 CNTFR solution structure of the carboxyl terminal domain of the ciliary neurotrophic factor receptor -1.0Å AUTH D.MAN,W.HE,K.H.SZE,K.GONG,D.K.SMITH,G.ZHU,N.Y.IPTITL SOLUTION STRUCTURE OF THE C-TERMINAL DOMAIN OF THETITL 2 CILIARY NEUROTROPHIC FACTOR (CNTF) RECEPTOR ANDTITL 3 LIGAND FREE ASSOCIATIONS AMONG COMPONENTS OF THETITL 4 CNTF RECEPTOR COMPLEXREF J.BIOL.CHEM. V. 278 23285 2003REFN ISSN 0021-9258PMID […]
General Structure Information 3k77 XRCC1 x-ray crystal structure of xrcc1 2.6Å AUTH M.J.CUNEO,R.E.LONDONTITL OXIDATION STATE OF THE XRCC1 N-TERMINAL DOMAIN REGULATESTITL 2 DNA POLYMERASE BETA BINDING AFFINITY.REF PROC.NATL.ACAD.SCI.USA V. 107 6805 2010REFN ISSN 0027-8424PMID 20351257DOI 10.1073/PNAS.0914077107 Variant Set Distributions Mapped Variants
General Structure Information 3r27 HNRNPL crystal structure of the first rrm domain of heterogeneous nuclear ribonucleoprotein l (hnrnp l) 2.04Å AUTH W.ZHANG,Y.LIU,F.ZENG,L.NIU,M.TENG,X.LITITL CRYSTAL STRUCTURE OF THE FIRST RRM DOMAIN OF HETEROGENEOUSTITL 2 NUCLEAR RIBONUCLEOPROTEIN L (HNRNP L)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1kq6 NCF1 p47phox px domain 1.18Å AUTH M.WAHL,H.DELBRUECK,H.OSCHKINAT,U.HEINEMANNTITL P47PHOX PX DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1×59 HARS solution structures of the whep-trs domain of human histidyl-trna synthetase -1.0Å AUTH N.NAMEKI,A.SASAGAWA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE WHEP-TRS DOMAIN OFTITL 2 HUMAN HISTIDYL-TRNA SYNTHETASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2yqf ANK1 solution structure of the death domain of ankyrin-1 -1.0Å AUTH W.TANABE,S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE DEATH DOMAIN OF ANKYRIN-1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2d85 LCP1 solution structure of the fourth ch domain from human l- plastin -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FOURTH CH DOMAIN FROMTITL 2 HUMAN L-PLASTINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants